Objective To investigate the correlation between the benign and malignant pulmonary nodules and serum inflammatory factors,tumor markers,and imaging features.Methods A total of 209 patients with pulmonary nodules who underwent lung puncture biopsy at the Third People's Hospital of Kunming from January 2023 to January 2024 were enrolled.Based on pathological results,the patients were divided into benign pulmonary nodules group(n=106)and malignant pulmonary nodules group(n=103).General data and clinical indicators of all subjects were collected,and differences in various indicators between the two groups were analyzed.Results In terms of Serum inflammatory factors:there were statistically significant differences in LYMPH,NLR,LMR,IL-2,IL-6,IL-17,IFN-γ,HsCRP,SAA,and PCT between the two groups(P<0.05),while no significant differences were found in WBC,NETU,MONO,PLT,SII,IL-5,IFN-α,IL-1β,IL-10,IL-8,and IL-12P70(P>0.05).Regarding Serum tumor markers:there were statistically significant differences in CEA,CA125,CA199,CYFRA21-1,ProGRP,and NSE between the two groups(P<0.05),whereas no significant differences were found in TSGF,AFP,and CA153(P>0.05).In terms of Imaging features:there were statistically significant differences in the number,diameter,boundary,fissure sign,spiculated sign,and pleural retraction sign of nodules between the two groups(P<0.05),while no significant differences were found in nodular calcification,nodule density,and location(P>0.05).Binary logistic regression analysis(backward-Wald conditional method)identified patient age,fissure sign,CEA,NSE,ProGRP,and IL-6 were independent risk factors for malignant pulmonary nodules(P<0.05).The combined diagnostic model of these indicators for predicting malignant pulmonary nodules had an AUC of 0.965(P<0.05).Conclusion Malignant pulmonary nodules are more likely in older patients with lobulation on imaging and elevated serum levels of NSE,ProGRP,IL-6,and CEA.Combined detection of these indicators can predict the nature of pulmonary nodules,guiding early diagnosis of malignant nodules.

Objective To investigate the correlation between angiotensinogen gene M235T polymorphism and gerontism hypertension combined with depression. Methods The polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique were used to detect the M235T genetic polymorphism in 117 patients with hypertension and 91 patients with hypertension and depression, and 101 healthy subjects without clinical evidence of hypertension and depression.Result The frequency of TT genetype and T allele was higher in group with hypertension and the group with hypertension and depression than that in the control group ( <0.05) . Conclusion Angiotensinogen gene M235T polymorphism is significantly correlated with the gerontism hypertension combined with depression.

Objective:To investigate the clinicopathological factors affecting the prognosis of colorectal cancer patients with liver metastasis and how to select therapeutic method. Methods:The clinical records of 146 colorectal cancer patients with liver metastases who were admitted in Cancer Hospital of Guizhou Province from March 1997 to March 2007 were collected and made a retrospective analysis. The survival rate of the 146 patients was calculated by using life table method. Kaplan-Meier method and log-rank test were used for univariate analysis on clinicopathological features and therapeutic modalities. The multivariate analysis was performed by using COX regression model. The prognostic index (PI) of patients was calculated based on the result of multivariate analysis. The patients were classified into different risk groups according to PI value and the survival rate was compared between the different groups. Rusults:The overall 1-, 3-, and 5-year survival rates were 62.0%, 15.5%and 6.2%, respectively. Univariate analysis revealed that the following factors were related with the prognosis of colorectal cancer patients with liver metastasis. They included pathological classification, histological grade, serum CEA(carcinoembryonic antigen)level, primary tumor resection, local lymph node metastasis, number and size of liver metastases, distribution and initiation time of liver metastases, extrahepatic invasion, with or without surgery and che-motherapy for liver metastasis, and chemotherapeutic regimen selection. Multivariate analysis showed that the serum CEA level, extrahepatic metastasis, number and size of liver metastases, primary tumor resection, and chemotherapeutic regimen were independent prognostic factors for colorectal patients with liver metastasis.Conclusion:The therapeutic modality had an obvious effect on the prognosis of colorectal cancer with liver metastasis. Active treatment for primary tumor and metastatic lesions increased the survival rate of patients. Serum CEA levels, with or without extrahepatic metastases, and the number and size of liver metastases were prognostic factors. PI value could be used to predict the prognosis of colorectal cancer patients with liver metastasis.