1.Hypofibrinogenemia induced by argatroban combined with urokinase
Shengye LIU ; Nianting GAO ; Xin'an WU ; Boxia LI
Adverse Drug Reactions Journal 2022;24(11):609-611
A 64-year-old male patient underwent diagnostic imaging of lower extremity venography plus inferior vena cava angiography due to deep vein thrombosis of lower extremity. Nadroparin calcium anticoagulation was given for 3 days before the operation, and heparin sodium anticoagulation was given after the operation. On the 3rd day of the operation, the coagulation function test showed fibrinogen (FIB) 2.78 g/L, activated partial thromboplastin time (APTT) 26.4 s. Continuous intravenous pumping of argatroban 1.5 μg/ (kg·min) (22 hours daily) and intravenously pumping of urokinase 600 000 U (lasting 2 hours) were given. On the 4th day of operation, the coagulation function test showed FIB 0.1 g/L and APTT 94.7 s. Considering the possible relation to drugs, urokinase was stopped, the dose of argatroban was reduced to 1.0 μg/(kg·min), and human fibrinogen was added. On the 5th day of operation, the coagulation function test showed FIB 0.49 g/L and APTT 51.2 s, and argatroban was stopped. On the 8th day of operation, the coagulation function test showed FIB 1.30 g/L and APTT 31.8 s, and fresh frozen plasma 750 ml was given twice daily by intravenous infusion. On the 11th day of operation, the coagulation function test showed FIB 2.40 g/L and APTT 28.3 s.
2.Hypofibrinogenemia induced by argatroban combined with urokinase
Shengye LIU ; Nianting GAO ; Xin'an WU ; Boxia LI
Adverse Drug Reactions Journal 2022;24(11):609-611
A 64-year-old male patient underwent diagnostic imaging of lower extremity venography plus inferior vena cava angiography due to deep vein thrombosis of lower extremity. Nadroparin calcium anticoagulation was given for 3 days before the operation, and heparin sodium anticoagulation was given after the operation. On the 3rd day of the operation, the coagulation function test showed fibrinogen (FIB) 2.78 g/L, activated partial thromboplastin time (APTT) 26.4 s. Continuous intravenous pumping of argatroban 1.5 μg/ (kg·min) (22 hours daily) and intravenously pumping of urokinase 600 000 U (lasting 2 hours) were given. On the 4th day of operation, the coagulation function test showed FIB 0.1 g/L and APTT 94.7 s. Considering the possible relation to drugs, urokinase was stopped, the dose of argatroban was reduced to 1.0 μg/(kg·min), and human fibrinogen was added. On the 5th day of operation, the coagulation function test showed FIB 0.49 g/L and APTT 51.2 s, and argatroban was stopped. On the 8th day of operation, the coagulation function test showed FIB 1.30 g/L and APTT 31.8 s, and fresh frozen plasma 750 ml was given twice daily by intravenous infusion. On the 11th day of operation, the coagulation function test showed FIB 2.40 g/L and APTT 28.3 s.
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