Six coumarins were isolated from two bioactive fractions of the 70% ethanol extract from the twigsand leaves of Wikstroemia indica (L.) C.A. Mey. (Thymelaeaceae), namely the ethyl acetate fraction (WIE) and the water fraction (WIW). These compounds were identified as umbelliferone (1), daphnoretin (2), daphnorin (3), adicardin (4), wikstronutin (5), and triumbelletin-7-O-β-D-glucoside (6). Compound 4 is reported for the first time in the genus Wikstroemia, whereas compound 5 is newly identified in this species. All six compounds were evaluated for their effects on Interleukin-1 beta (IL-1β) and IL-10 secretion in Lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages, among which compounds 1, 2, 5, and 6 showed stronger activity. These four coumarin derivatives further suppressed the production of Foxp3, Interferon-alpha (IFN-α), IFN-γ, and IL-17 in LPSstimulated CD4+ T cells. The IC50 values ranged from 18.84 ± 1.16 to 43.45 ± 5.34 μM for Foxp3, 8.96 ± 1.45 to 22.42 ± 4.12 μM for IFN-α, 9.28 ± 1.23 to 16.83 ± 2.15 μM for IFN-γ, and 12.62 ± 2.57 to 22.92 ± 4.41 μM for IL-17. Notably, compound 6 exhibited the strongest immunomodulatory effect. Overall, the findings suggest that coumarins from W. indica possess promising immunomodulatory and anti-inflammatory potential.

STRESS IN RELATIONSHIP WITH BURNOUT DUE TO COVID-19: THE MODERATING ROLE OF COPING STRATEGIES This study investigates the relationship between stress and burnout related to the COVID-19 pandemic, focusing on the moderating influence of positive and negative coping strategies. In a cross-sectional survey involving 3,664 Vietnamese citizens aged 18 and above, the research explores the dynamics of stress and burnout symptoms associated with the ongoing pandemic. The results reveal a negative impact of stress symptoms on COVID-19-related burnout among the population. Notably, both positive and negative coping strategies are identified as significant moderators in the interplay between stress and burnout. This suggests that individuals’ coping mechanisms influence the severity of stress and burnout experienced in dealing with COVID-19 challenges. These findings contribute to the foundational understanding of the stress-burnout relationship during the pandemic and provide essential insights for interventions. By recognizing the moderating role of coping strategies, this study lays the groundwork for strategies aimed at enhancing individuals’ coping abilities, ultimately reducing stress and burnout levels. These insights hold the potential to assist individuals in adapting more effectively to the challenges posed by the COVID-19 pandemic, fostering improved mental well-being in the face of ongoing uncertainties. ASEAN Journal of Psychiatry, Vol. 25 (3) March, 2024; 1-10.

Background: Since January 2004, laparoscopic appendectomy is performed in Department of Surgery in Hue College of Medicine and Pharmacy Hospital and having fully satisfactory results. Objective: To review the applying laparoscopic appendectomy in Hue College of Medicine and Pharmacy Hospital. Subjects and method: A study included 1,765 patients with acute or chronic appendicitis, who operated in Hue College of Medicine and Pharmacy Hospital. This was a clinical, descriptive, retrospective, intervention, non-comparison, longitudinal follow-up study. Results: The patients\ufffd?average age was 41\xb125 years (ranged from 5 to 78 years). 61.5% of patients were females, 38.5% were males. The over 20 to 40 year-old group made up 54.4%, following 5-20 year-old group (19.5%), over 40 to 60 year-old group (18.6%). Most patients were operated within 24 hours from the onset of disease. 48.6% of patients had normal appendix location. Only eight cases (0.45%) had peri- and post-operative infections at Trocar hole. The average time of hospital stay was 3\xb11.7 days (ranged from 2 to 7 days). Conclusion: Laparoscopic appendectomy was a safe and effective selective method for appendicitis with many remarkable advantages.
Appendectomy ; Appendicitis/ therapy ;

The study carried out on 50 cases with intra-dural meningiomas and schwannomas at Nerous Deparmen of Bachmai hospital. The result showed that: magnetic resonance imaging of intra-dural meningiomas and schwannomas have own feature and basic on the feature can define and distinguish 2 types of tumor. Meningiomas has identical intermediate sign on T1 imaging, increase identical intermediate sign on T2 imaging. The tumor soak photomagnetic strongly and identically, show in thick of dura mater at contignuous region with tumor and can see sign of dura mater tail after injection photomagnetic, rare to see making cocoon in tumor. Schwannomas have identical intermediate or descreasing sign on T1 inmaging, increase sign on T2. The tumor also soak photomagnetic strongly but no identically, making cocoon in tumor, margin part of tumor soak photomagnetic more strong. There is big rate of tumor developing through conjugate hole out of intra-dural.
Magnetic Resonance Imaging ; Meningioma ; Neurilemmoma

Studying 50 cases with spinal intramedullary tumor at Nerve Department of Bach Mai hospital to diagnose before surgering from 1998 to 2003. Among them, 6 cases with ependymomas and 3 with astrocytomas were taken magenetic resonance. Result showed that ependymomas and astrocytomas were two major typies in intramedullary tumors. Magenetic resonance imaging has some characterstics helping identify these typies according to considering different factors (ex age, site of tumor). Eoendymomas is more in adult. Astrocytomas is more in children.
Magnetic Resonance Imaging ; Diagnosis ; Spinal Cord Neoplasms ; Ependymoma ; Astrocytoma