Objective To explore the relationship between the levels of hepatic fibrosis markers and peripheral venous pressure(PVP)in patients with chronic heart failure(CHF),as well as their correlation with the risk of poor prognosis in these patients.Methods A retrospective study was conducted on 216 elderly CHF patients admitted in Department of Cardiology,Qingdao Sixth People's Hospital from June 2021 to December 2024.Based on the occurrence of adverse cardiovascular events during 1-year follow-up,the patients were divided into a poor prognosis group(94 cases)and a good prognosis group(122 cases).The levels of hepatic fibrosis markers and PVP at discharge were collected.Multivariate logistic regression analysis was applied to explore the independent association of the marker levels and PVP with risk of poor prognosis.Results The good prognosis group had significantly reduced PVP,and lower levels of NT-proBNP,hyaluronic acid,type Ⅲ procollagen(PCⅢ),laminin(LN),type Ⅳ collagen(CⅣ),and 7S domain of type Ⅳ collagen N-terminal propeptide(P4NP 7S)when compared with the poor prognosis group(P＜0.05,P＜0.01).PVP was positively correlated with P4NP 7S,hyaluronic acid,CⅣ,PCⅢ and LN(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that NT-proBNP,PVP,hyaluronic acid,CⅣ,and P4NP 7S were independent risk factors for poor prognosis in CHF patients(P＜0.05,P＜0.01).ROC curve analysis revealed that the AUC value of combined hepatic fibrosis markers and PVP in predicting poor prognosis in CHF patients was 0.946(95％CI:0.907～0.972).Conclusion The levels of hepatic fibrosis markers are closely correlated with PVP in CHF patients.Combination of P4NP 7S,hyaluronic acid,CⅣ,and PVP can be used to assess the risk of adverse cardiovascular events and predict the prognosis of CHF patients.

Objective To explore the relationship between the levels of hepatic fibrosis markers and peripheral venous pressure(PVP)in patients with chronic heart failure(CHF),as well as their correlation with the risk of poor prognosis in these patients.Methods A retrospective study was conducted on 216 elderly CHF patients admitted in Department of Cardiology,Qingdao Sixth People's Hospital from June 2021 to December 2024.Based on the occurrence of adverse cardiovascular events during 1-year follow-up,the patients were divided into a poor prognosis group(94 cases)and a good prognosis group(122 cases).The levels of hepatic fibrosis markers and PVP at discharge were collected.Multivariate logistic regression analysis was applied to explore the independent association of the marker levels and PVP with risk of poor prognosis.Results The good prognosis group had significantly reduced PVP,and lower levels of NT-proBNP,hyaluronic acid,type Ⅲ procollagen(PCⅢ),laminin(LN),type Ⅳ collagen(CⅣ),and 7S domain of type Ⅳ collagen N-terminal propeptide(P4NP 7S)when compared with the poor prognosis group(P＜0.05,P＜0.01).PVP was positively correlated with P4NP 7S,hyaluronic acid,CⅣ,PCⅢ and LN(P＜0.05,P＜0.01).Multivariate logistic regression analysis showed that NT-proBNP,PVP,hyaluronic acid,CⅣ,and P4NP 7S were independent risk factors for poor prognosis in CHF patients(P＜0.05,P＜0.01).ROC curve analysis revealed that the AUC value of combined hepatic fibrosis markers and PVP in predicting poor prognosis in CHF patients was 0.946(95％CI:0.907～0.972).Conclusion The levels of hepatic fibrosis markers are closely correlated with PVP in CHF patients.Combination of P4NP 7S,hyaluronic acid,CⅣ,and PVP can be used to assess the risk of adverse cardiovascular events and predict the prognosis of CHF patients.

Objective To test the antimicrobial susceptibility of Staphylococcus aureus from children with impetigo,and to assess the differences in randomly amplified polymorphic DNA profiles between sensitive and resistant Staphylococcus aureus strains.Methods Secretion specimens were obtained from the impetiginous lesions of 178 children,and subjected to bacterial culture.The susceptibility of 162 Staphylococcus aureus isolates against 21 antibiotics was tested.Randomly amplified polymorphic DNA PCR(RAPD-PCR)was performed to characterize the genotype of Staphylococcus aureus.Results Totally,180 bacterial strains were isolated from 178 children with impetigo in Chengdu,including 162(90.00％)Staphylococcus aureus strains.Of the 162 Staphylococcus aureus strains,148 were methicillin sensitive Staphylococcus aureus(MSSA),14 methicillin resistant Staphylococcus aureus(MRSA).The most active antibiotic was minocycline,followed by teicoplanin,quinupristin,vancomycin and nitrofurantoin,while the resistance rate to penicillin was highest,followed by that to erythromycin,clindamycin,compound sulfamethoxazole and tetracycline.All the Staphylococcus aureus isolates were sensitive to fusidic acid,nitrofurantoin,vancomycin,minocycline and teicoplanin.According to RAPD-PCR,the 162 Staphylococcus aureus strains were divided into 8 genotypes,with the three most prevalent genotypes being Ⅲ(31.48％),Ⅱ(26.54％)and Ⅵ(25.93％),which accounted for 65.43％(106/162)in all the strains.The 148 MSSA strains fell into 8 genotypes,with genotype Ⅲ(50 strains,33.78％),Ⅵ(39 strains,26.35％)and Ⅱ(33 strains,22.30％)being the most prevalent genotypes;the 14 MRSA strains fell into 3 genotypes,i.e.,genotype Ⅱ(10 strains,71.43％),Ⅵ(3 strains,21.43％),and Ⅲ(1 strain,7.14％).Conclusions Staphylococcus aureus is the most prevalent pathogenic bacteria in children with impetigo in Chengdu area,which is highly sensitive to minocycline,teicoplanin and quinupristin,and falls into 8 genotypes according to RAPD-PCR with genotype Ⅲ being the most common genotype.

Not Abstract.