Objective:To study the feasibility, safety and effectiveness of single-port laparoscopic retroperitoneal debridement for infectious necrotizing pancreatitis.Methods:The clinical data of 63 patients with residual infectious stage of infectious necrotizing pancreatitis treated at the Qilu Hospital of Shandong University from October 2012 to August 2017 were retrospectively analyzed. A total of 33 patients who underwent single-port laparoscopic retroperitoneal debridement were classified as the study group, while the remaining 30 patients who underwent traditional open surgery served as the control group.Results:One patient in the study group died 20 days after surgery, while three patients in the control group died after surgery. The operation time, intraoperative blood loss, hospitalization cost, surgical site infection rate, postoperative hospital stay and other parameters in the study group were significantly lower than those in the control group (all P<0.05). There were no significant differences in the incidences of postoperative colon fistula, incisional hernia and gastroparesis between the two groups (all P>0.05). After a follow-up which ranged from 6.0 to 48.0 months, there was no newly diagnosed diabetic patients in the study group, but 2 in the control group. The difference was not significantly different ( P>0.05). Conclusion:Single-port laparoscopic retroperitoneal debridement had the advantages of safety, feasibility and fast postoperative recovery with significant curative effects.