Professor Wang Jinda,as the founder of emergency medicine combining traditional Chinese and Western medicine,not only integrated the profoundness of Chinese medicine and the precision of western medicine,but also made bold innovations and breakthroughs on this basis.This article aims to review and deeply study the evolution and contribution professor Wang Jinda's academic thoughts over the past 50 years,including the establishment of the acute"three failure"rescue research laboratory[professor Wang Jinda took the lead in introducing the specialty of emergency medicine into China and established the first emergency medicine research institution in China,the acute"three failure"(heart,lung,kidney)rescue research laboratory and the intensive care unit(ICU)of the Tianjin First Central Hospital],the proposal of the"three symptoms and methods"and the"simultaneous treatment of bacterial toxin and inflammation"theory[the treatment of sepsis,disseminated intravascular coagulation(DIC),and multiple organ dysfunction syndrome(MODS)was summarized as"three symptoms and three methods",namely,the syndrome of toxic heat and the of clearing away heat and toxic materials,the syndrome of blood stasis and the method of promoting blood circulation and removing blood stasis,and the syndrome of acute deficiency the method of supporting the healthy qi and consolidating the foundation],and the development of the Xuebijing injection(under the guidance of professor Wang Jinda's thoughts,the Xuebijing injection,which was modified from the"Xuefu Zhuyu decoction"of the Qing dynasty Wang Qingren has been proven by various experimental studies and clinical observations that it can improve the treatment effect of critical diseases such as sepsis through various mechanisms),which reveals his achievements in the field of emergency medicine for critical diseases.At the same time,his academic achievements have been verified by evidence-based medicine and have definite clinical value in the of critical diseases,and also provide references for subsequent clinical research.

Professor Wang Jinda,as the founder of emergency medicine combining traditional Chinese and Western medicine,not only integrated the profoundness of Chinese medicine and the precision of western medicine,but also made bold innovations and breakthroughs on this basis.This article aims to review and deeply study the evolution and contribution professor Wang Jinda's academic thoughts over the past 50 years,including the establishment of the acute"three failure"rescue research laboratory[professor Wang Jinda took the lead in introducing the specialty of emergency medicine into China and established the first emergency medicine research institution in China,the acute"three failure"(heart,lung,kidney)rescue research laboratory and the intensive care unit(ICU)of the Tianjin First Central Hospital],the proposal of the"three symptoms and methods"and the"simultaneous treatment of bacterial toxin and inflammation"theory[the treatment of sepsis,disseminated intravascular coagulation(DIC),and multiple organ dysfunction syndrome(MODS)was summarized as"three symptoms and three methods",namely,the syndrome of toxic heat and the of clearing away heat and toxic materials,the syndrome of blood stasis and the method of promoting blood circulation and removing blood stasis,and the syndrome of acute deficiency the method of supporting the healthy qi and consolidating the foundation],and the development of the Xuebijing injection(under the guidance of professor Wang Jinda's thoughts,the Xuebijing injection,which was modified from the"Xuefu Zhuyu decoction"of the Qing dynasty Wang Qingren has been proven by various experimental studies and clinical observations that it can improve the treatment effect of critical diseases such as sepsis through various mechanisms),which reveals his achievements in the field of emergency medicine for critical diseases.At the same time,his academic achievements have been verified by evidence-based medicine and have definite clinical value in the of critical diseases,and also provide references for subsequent clinical research.

Objective To investigate the prevention of distant multiple organ dysfunction caused by lower limb ischemia/reperfusion with taurine.Methods Wistar rats were randomly divided into 3 groups.(1)Reperfusion group:rats underwent 2-hour bilateral artery femoralis of hind limbs ischemia and followed by 5 hours reperfusion.(2)Taurine group:each rat was oraled 20% taurine 3ml every day for 7 days and underwent 2hrs ischemia followed by 5 hrs reperfusion.(3)Control group:sham animals didn't undergo ischemia.The count of leukocyte,myocardial and liver enzymes were measured.Ultrastructural pathological change of distant organs were observed.Superoxide dismutase(SOD) of erythrocyte,malondialdehyde(MDA) glutathione(GSH) and tumor necrosis factor(TNF) in tissue homogenization was assayed.Results The count of leukocyte was decreased significantly in reperfusion group,myocardial and liver enzymes were significantly increased compared with control group ultrastructural pathological change of extensive injury of distant multiple organs was occurred in perfusion group.SOD of erythrocyte and GSH in serum were decreased compared with control group,while MDA and tumor necrosis factor in tissue homogenization of liver and lung were significantly increased.The pathological changes of taurine group was obviously alleviate.Conclusion Limb ischemia/reperfusion can produce quantities of oxygen free radicals and TNF which were released by activated polymornuclear leukocytes.This made the body plunge into systemic inflammation response syndrome and induce distant multiple organ dysfunction.Taurine can prevent it obviously.