Objective:To analyze the clinical data of patients with severe fever with thrombocytopenia syndrome（SFTS）in Linyi city of Shandong province from 2023 to 2024，analyze the related factors affecting the prognosis，improve the understanding of the disease and reduce its mortality..Methods:The data of 36 SFTS patients diagnosed and admitted to Linyi People's Hospital from May 2023 to August 2024 were retrospectively analyzed. According to the clinical outcomes of the patients，they were divided into a survival group（n=30）and a death group（n=6）. The clinical data and laboratory test results of the two groups were analyzed to evaluate the risk factors related to prognosis.Results:The median age in the death group was 68.33 years old，and that in the survival group was 63.96 years old，with no statistically significant difference. All patients had fever，22 had fatigue and poor appetite，and 21 had muscle aches and other systemic symptoms. some were prone to general symptoms such as fatigue，poor appetite，and muscle soreness. All patients in the death group had neurological symptoms such as headache and consciousness disorders. The levels of serum potassium，CRP，PCT，IL-6，ALT，AST，CK，CK-MB，LDH，α-HBDH，APTT，D-D，and viral load in the death group were higher than those in the survival group，with statistically significant differences（ t=-3.344， P=0.002； Z=-2.195， P=0.028； Z=-3.648， P=0.000； Z=-3.641， P=0.000； Z=-2.241， P=0.025； Z=-2.288， P=0.022； Z=-2.427， P=0.015； Z=-2.007， P=0.045； Z=-3.127， P=0.002； Z=-2.404， P=0.016； Z=-2.755， P=0.006； Z=-3.081， P=0.002； P<0.05）. The platelet count in the death group was lower than that in the survival group，and the difference was statistically significant（ Z=-3.292， P=0.001， P<0.05）. Multivariate Logistic regression analysis showed that patients with increased AST，CK，IL-6，APTT，D-dimer and decreased platelet count had an increased risk of death. Fungal infections occurred in 15 cases，including 5 cases of Candida albicans，3 cases of Candida parapsilosis，and 7 cases of Aspergillus. All patients in the death group had fungal infections，all of whom had Aspergillus infections. Conclusion:SFTS patients often have fever，fatigue，and muscle soreness，and critically ill patients are prone to neurological symptoms. Patients with elevated AST，CK，IL-6，APTT，D-D，viral load，and decreased platelet count in the course of the disease often indicate poor prognosis and should be closely monitored. In addition，critically ill patients are prone to fungal infection.

Objective:To analyze the clinical data of patients with severe fever with thrombocytopenia syndrome（SFTS）in Linyi city of Shandong province from 2023 to 2024，analyze the related factors affecting the prognosis，improve the understanding of the disease and reduce its mortality..Methods:The data of 36 SFTS patients diagnosed and admitted to Linyi People's Hospital from May 2023 to August 2024 were retrospectively analyzed. According to the clinical outcomes of the patients，they were divided into a survival group（n=30）and a death group（n=6）. The clinical data and laboratory test results of the two groups were analyzed to evaluate the risk factors related to prognosis.Results:The median age in the death group was 68.33 years old，and that in the survival group was 63.96 years old，with no statistically significant difference. All patients had fever，22 had fatigue and poor appetite，and 21 had muscle aches and other systemic symptoms. some were prone to general symptoms such as fatigue，poor appetite，and muscle soreness. All patients in the death group had neurological symptoms such as headache and consciousness disorders. The levels of serum potassium，CRP，PCT，IL-6，ALT，AST，CK，CK-MB，LDH，α-HBDH，APTT，D-D，and viral load in the death group were higher than those in the survival group，with statistically significant differences（ t=-3.344， P=0.002； Z=-2.195， P=0.028； Z=-3.648， P=0.000； Z=-3.641， P=0.000； Z=-2.241， P=0.025； Z=-2.288， P=0.022； Z=-2.427， P=0.015； Z=-2.007， P=0.045； Z=-3.127， P=0.002； Z=-2.404， P=0.016； Z=-2.755， P=0.006； Z=-3.081， P=0.002； P<0.05）. The platelet count in the death group was lower than that in the survival group，and the difference was statistically significant（ Z=-3.292， P=0.001， P<0.05）. Multivariate Logistic regression analysis showed that patients with increased AST，CK，IL-6，APTT，D-dimer and decreased platelet count had an increased risk of death. Fungal infections occurred in 15 cases，including 5 cases of Candida albicans，3 cases of Candida parapsilosis，and 7 cases of Aspergillus. All patients in the death group had fungal infections，all of whom had Aspergillus infections. Conclusion:SFTS patients often have fever，fatigue，and muscle soreness，and critically ill patients are prone to neurological symptoms. Patients with elevated AST，CK，IL-6，APTT，D-D，viral load，and decreased platelet count in the course of the disease often indicate poor prognosis and should be closely monitored. In addition，critically ill patients are prone to fungal infection.

Objective To evaluate the necessity of prophylactic uterine artery embolization (UAE) before curettage in treatment of cesarean scar pregnancy (CSP).Methods A total of 142 patients with CSP were enrolled and divided into 3 groups according to Adler grading standard,including little vascularity (grade 0-Ⅰ,n=40),moderate vascularity (grade Ⅱ,n=41) and rich vascularity groups (grade Ⅲ,n=61).All patients were treated with curettage or prophylactic UAE before curettage.The differences of age,times of cesarean section,time to last cesarean section,intraoperative blood loss and success rate of therapy were compared between different treatment methods in each group.Results There was no statistical difference of age,times of cesarean section,time to last cesarean section,intraoperative blood loss and success rate of therapy between curettage and prophylactic UAE before curettage in little vascularity group and moderate vascularity group (all P＞0.05).Compared with curettage,the success rate of prophylactic UAE before curettage was higher and the intraoperative blood loss was lower in rich vascularity group (both P＜0.05).There was no statistical difference of age,times of cesarean section nor time to last cesarean section in rich vascularity group (all P＞0.05).Conclusion It is necessary to perform prophylactic UAE before curettage for cesarean scar pregnancy patient with rich vascularity,which is helpful to reduction of intraoperative blood loss.

Objective To investigate the expression of arginase Ⅰ (.Arg Ⅰ) in peripheral superficial lymph nodes of HIV-infected individuals and to explore their correlation with HIV/AIDS disease progression.Methods All the patients were divided to two groups according to the CD4 + T cell counts in peripheral blood,immunohistochemistry was used to detect expression of Arg Ⅰ in peripheral superficial lymph node of non HIV-infected and HIV-infected individuals.The data were statistically analyzed with SPSS17.0.Results Levels of Arg Ⅰ expression in peripheral superficial lymph node of HIV-infected individuals were higher than those of non HIV-infected lymph nodes (P ＜ 0.01).The expressions of Arg Ⅰ in patients with AIDS in different CD4 + T lymphocyte counts were distinct.Levels of Arg Ⅰ expression in peripheral superficial lymph nodes of CD4 + T lymphocyte counts ≥350/ μl and 200/ μl ≤ CD4 + T lymphocyte counts ＜ 350/ μl AIDS patients had no significant difference (P ＞ 0.05),while there was significant difference between expression of Arg Ⅰ in CD4 + T lymphocyte counts ≥ 350/ μl,200/ μl ≤ CD4 + T lymphocyte counts ＜ 350/ μl and CD4 + T lymphocyte counts ＜ 200/ μl AIDS patients (P ＜ 0.05).In addition,statistical analysis of the above results showed that CD4 +T cell counts in peripheral blood were negatively correlated with expression level of Arg Ⅰ.Conclusions Levels of Arg Ⅰ expression in peripheral superficial lymph node of AIDS patients were significantly high and associated with disease progression.

Objective To investigate the clinical characteristics of patients infected with human adenovirus type 7 and to provide guidance for early diagnosis and timely control of the outbreak.Methods A total of 301 patients infected with the human adenoviruses who were quarantined in hospital from December 2012 to February 2013 were observed.Epidemiological questionnaires were used to collect data of clinical features of the disease including symptoms,signs,images and laboratory tests.To confirm infection,real time polymerase chain reaction was performed using patients' swabs to detect viral nucleotide.Results Most cases happened in December to the next February.Totally 277 cases of the 301 patients were male,and only 24 cases were female.Mean age was (19.1±1.9) years old,range 15 to 29 years old.Identifiable epidemiologic links were seen between patients.The most common symptoms were fever (100.0％),cough (70.4％),expectoration (48.2％),and sore throat (47.8％).In addition,some patients presented with headache,dizziness,chills,fatigue.The most common signs were pharyngeal congestion (62.5％),enlargement of tonsils (56.5％) and lymphatic follicular hyperplasia (26.6％).Some patients' tonsil was covered with white secretions.Lung images were abnormal in 75 cases,which were presented with mild pneumonia with or without surrounding exudative lesions and pleural effusion in lung images.Laboratory tests showed that the number of white blood cells in the peripheral blood in most of the patients (99.0 ％) was elevated or normal.The proportions of neutrophils (54.2％) and monocytes (80.7％) and the level of C-reactive protein (42.2％) increased,while the proportion of lymphocytes reduced (67.1％).The average course of disease was (6.6±2.9) d.With the treatment of intravenous ribavirin and reduning,all patients were cured.Conclusions Human adenovirus type 7 is quite contagious and may cause epidemic outbreak,especially in winter.The majority exhibits mild symptoms of upper respiratory tract infection with short duration,including fever,cough,expectoration and sore throat.Through timely and active treatment,all patients have a good prognosis.