Introduction: Phase angle (PhA) derived from bioelectrical impedance analysis reflects cellular integrity and has emerged as a potential marker of metabolic health. Its role in detecting early physiological changes during lifestyle intervention remains underexplored in workplace obesity programmes. Methodology: This longitudinal study included 30 adults with complete paired measurements enrolled in a 12-month workplace lifestyle programme. Body composition was assessed using multifrequency bioelectrical impedance analysis. Measurements included whole-body PhA, body cell mass (BCM), skeletal muscle index (SMI), and extracellular water to total body water ratio. Paired comparisons and correlation analyses were performed. Results: Mean PhA increased modestly from 5.59 ± 0.70° to 5.67 ± 0.69°, although this did not reach statistical significance (p = 0.17). Changes in PhA were not significantly associated with changes in BCM (r = −0.03, p = 0.89). However, baseline PhA demonstrated a moderate positive association with SMI (r ≈ 0.51, p <0.01), suggesting a link between cellular integrity and muscle status. Individual trajectories revealed heterogeneous responses despite minimal weight change. Conclusion Whole-body phase angle provides insight into cellular health beyond conventional anthropometric measures. While short-term changes were modest, PhA may serve as a clinically useful adjunct for monitoring physiological response in obesity management programmes.
Workplace

Introduction: Obesity is a heterogeneous metabolic disease in which individuals with similar body weight may exhibit markedly different physiological risk profiles. Conventional monitoring using weight alone may fail to capture underlying metabolic and cellular changes during lifestyle intervention. Integrating body composition and biochemical markers may improve risk stratification in clinical practice. Methodology: A prospective observational analysis was conducted among participants enrolled in a structured lifestyle programme. Baseline and follow-up assessments included biochemical markers (fasting glucose, renal function, lipid profile, and liver enzymes) alongside body composition parameters derived from bioelectrical impedance analysis, including percent body fat, visceral fat area, skeletal muscle index (SMI), and phase angle (PhA). Changes over time and associations between metabolic and body composition variables were analyzed. Results: Metabolic responses varied substantially despite similar anthropometric profiles. Renal function improved significantly, with increased estimated glomerular filtration rate (eGFR) observed over time (p = 0.01), and was inversely associated with fasting glucose (r = −0.41, p <0.01). Lipid abnormalities persisted, although reductions in lowdensity lipoprotein cholesterol were noted (p = 0.04). Total cholesterol remained elevated and correlated positively with fasting glucose (r = 0.36, p = 0.02). Improvements in aspartate aminotransferase were observed (p = 0.03), while other liver markers remained stable. Notably, body composition parameters, including PhA and SMI, demonstrated variability independent of weight change, reflecting heterogeneous physiological adaptation. Conclusion Metabolic and physiological responses to lifestyle intervention are heterogeneous and not fully captured by changes in body weight alone. The integration of bioimpedance-derived parameters with biochemical markers provides a more comprehensive approach to metabolic risk stratification and may support more personalized clinical management in obesity care.
Biomarkers ; Risk Assessment ; Body Composition

Introduction: Obesity is a chronic disease characterized by complex alterations in body composition and metabolic health. Traditional reliance on body weight may overlook important physiological adaptations during lifestyle intervention. Methodology: A cohort of 99 participants at programme entry underwent body composition assessment using bioelectrical impedance analysis. Parameters included percent body fat (PBF), visceral fat area (VFA), skeletal muscle index (SMI), and phase angle (PhA). Correlation analyses were performed to explore relationships between adiposity, muscle mass, and cellular health. Results: Participants demonstrated elevated adiposity (PBF 38.9 ± 8.9%; VFA 142.9 ± 56.1 cm²). PhA was inversely associated with VFA (r ≈ −0.23, p <0.05) and positively associated with SMI (r ≈ 0.49, p <0.001). Notably, a subset of overweight individuals exhibited relatively preserved PhA, indicating heterogeneity in metabolic health despite similar adiposity levels. Conclusion Body composition and PhA provide complementary insights into metabolic health beyond body weight. These findings support the role of bioimpedance-derived parameters in identifying metabolic heterogeneity and guiding personalized obesity management.
Body Composition ; Body Weight ; Workplace ; Obesity

We report a rare case of high-volume training-related myopericarditis. A male, 18 years old, elite road bicycle racing cyclist with high-volume training of 1,000 km per week for >7 years, presented with progressively worsening exertional breathlessness, reduced effort tolerance, and one episode of cardiac syncope. The symptoms were present prior to the coronavirus disease 2019 pandemic but made worse with the sudden increase in the volume of training after lockdown periods in preparation for competition. He exhibited multiple premature ventricular ectopic beats during his resting electrocardiogram, with a normal echocardiogram and non-elevated cardiac enzyme. The exercise stress test revealed similar multiple premature ventricular beats, warranting further investigation using cardiac magnetic resonance imaging (MRI). The findings of the cardiac MRI were suggestive of myopericarditis. He was instructed to refrain from training and initially started with a short course of colchicine. However, his symptoms deteriorated, and cardiac MRI revealed a decrease in the left ventricular ejection fraction from 59% to 50%. His treatment was escalated to a short course of tapered dose steroid, anti-failure medication and gradual, supervised, return to sports program. This case report highlights the discussion of return to play in athletes with myopericarditis.

Background: Most international bodies recommended against musculoskeletal steroid injection during the COVID-19 pandemic, fearing that the immunosuppressive effects of the steroid could worsen COVID-19 infection, thus prolonging the suffering of patients with severe musculoskeletal disease. The authors’ aim is to analyze the risk of COVID-19 infection after musculoskeletal injections. Methods: This is a retrospective study of patients who visited a sports medicine clinic and received musculoskeletal steroid injections between January 1, 2020 and February 28, 2021. The collected data was compared with the national COVID-19 registry to identify positive COVID-19 patients. The patients were only considered positive for COVID-19 following corticosteroid injection within 3 months after injection. Results: Out of 502 steroid injections; 79.7% (n = 400) received a single injection in one day, 19.1% (n = 96) received steroid injections at 2 sites in one day, and 1.2% (n = 6) received steroid injections at 3 sites in one day. Using the Fisherʼs exact test, there was no statistically significant association of COVID-19 infection between the steroid group and control group (relative risk, 1.44; 95% confidence interval, 0.9–23.1, P = 0.654). Only one patient contracted mild COVID-19 with no post COVID complications. Conclusions The authors recommend the use of musculoskeletal steroid injections in clinically indicated situation without having increased risk of COVID-19.

Anterior cruciate ligament (ACL) tears are serious knee injuries, whether partial or total. ACL injuries are most typically diagnosed in the clinic settings using a combination of a detailed history, physical examination and corroborated with an appropriate imaging modality. Magnetic resonance imaging (MRI) is highly sensitive for identifying intra-articular knee pathology. This combination has been demonstrated to be effective and non-invasive in diagnosing ACL injury. The reliability of MRI for diagnostic purposes, on the other hand, is not always ideal. This might be due to various factors, including low-quality MRI magnets, post-surgical tissue changes, metallic artifacts, patient movement during procedure, and static rather than dynamic structural evaluation. Nevertheless, office-based diagnostic arthroscopy offers an alternative to imaging modalities by allowing clinicians to visualize large joints safely, painless, high-quality images, and time-efficient approaches. Furthermore, the risk of major and minor complications of office-based diagnostic arthroscopy is comparable to or lower than any standard office-based injection. This is the first office-based needle arthroscopy (OBNA) performed in Malaysia to evaluate intra-articular knee symptoms. Thus, we aim to understand and overview OBNA to identify intra-articular knee pathology by reporting this case report.
Anterior Cruciate Ligament Injuries