Adult ; Anticonvulsants ; therapeutic use ; Brain ; drug effects ; pathology ; physiopathology ; Carbamazepine ; analogs & derivatives ; therapeutic use ; Electroencephalography ; Epilepsy, Frontal Lobe ; diagnosis ; drug therapy ; Female ; Humans ; Myoclonic Epilepsy, Juvenile ; diagnosis ; drug therapy ; Myoclonus ; diagnosis ; drug therapy

OBJECTIVE: We aimed to find structural brain abnormalities in juvenile myoclonic epilepsy (JME) patients. MATERIALS AND METHODS: The volumes of the cerebrum, hippocampus and frontal lobe and the area of the corpus callosum's subdivisions were all semi-automatically measured, and then optimized voxel-based morphometry (VBM) was performed in 19 JME patients and 19 age/gender matched normal controls. RESULTS: The rostrum and rostral body of the corpus callosum and the left hippocampus were significantly smaller than those of the normal controls, whereas the volume of the JME's left frontal lobe was significantly larger than that of the controls. The area of the rostral body had a significant positive correlation with the age of seizure onset (r = 0.56, p = 0.012), and the volume of the right frontal lobe had a significant negative correlation with the duration of disease (r = -0.51, p = 0.025). On the VBM, the gray matter concentration of the prefrontal lobe (bilateral gyri rectus, anterior orbital gyri, left anterior middle frontal gyrus and right anterior superior frontal gyrus) was decreased in the JME group (corrected p < 0.05). CONCLUSION: The JME patients showed complex structural abnormalities in the corpus callosum, frontal lobe and hippocampus, and also a decreased gray matter concentration of the prefrontal region, which all suggests there is an abnormal neural network in the JME brain.
*Signal Processing, Computer-Assisted ; Organ Size ; Myoclonic Epilepsy, Juvenile/*pathology ; Male ; Magnetic Resonance Imaging/*methods ; Imaging, Three-Dimensional/*methods ; Image Interpretation, Computer-Assisted/*methods ; Humans ; Female ; Brain/*pathology ; Adult