Meconium aspiration syndrome (MAS) is defined as respiratory distress in newborn infants born through meconium-stained amniotic fluid whose symptoms cannot be otherwise explained. MAS is characterized by hypoxemia, hypercapnia and acidosis that continues to be associated with signifi cant morbidities and mortality. Worldwide, the incidence has declined due to improved obstetric and perinatal care. The pathophysiological mechanism of MAS include perinatal hypoxia, acute airway obstruction, pulmonary and systemic inflammation, surfactant inactivation and persistent pulmonary hypertension of the newborn (PPHN). Respiratory and hemodynamic supports are main therapies for MAS. Early identification and appropriate management of PPHN is important as it associates with significant mortality and morbidities. This review suggests a comprehensive overview of the epide miology, diagnosis, management, prognosis and prevention of MAS.

Meconium aspiration syndrome (MAS) is defined as respiratory distress in newborn infants born through meconium-stained amniotic fluid whose symptoms cannot be otherwise explained. MAS is characterized by hypoxemia, hypercapnia and acidosis that continues to be associated with signifi cant morbidities and mortality. Worldwide, the incidence has declined due to improved obstetric and perinatal care. The pathophysiological mechanism of MAS include perinatal hypoxia, acute airway obstruction, pulmonary and systemic inflammation, surfactant inactivation and persistent pulmonary hypertension of the newborn (PPHN). Respiratory and hemodynamic supports are main therapies for MAS. Early identification and appropriate management of PPHN is important as it associates with significant mortality and morbidities. This review suggests a comprehensive overview of the epide miology, diagnosis, management, prognosis and prevention of MAS.

Meconium aspiration syndrome (MAS) is defined as respiratory distress in newborn infants born through meconium-stained amniotic fluid whose symptoms cannot be otherwise explained. MAS is characterized by hypoxemia, hypercapnia and acidosis that continues to be associated with signifi cant morbidities and mortality. Worldwide, the incidence has declined due to improved obstetric and perinatal care. The pathophysiological mechanism of MAS include perinatal hypoxia, acute airway obstruction, pulmonary and systemic inflammation, surfactant inactivation and persistent pulmonary hypertension of the newborn (PPHN). Respiratory and hemodynamic supports are main therapies for MAS. Early identification and appropriate management of PPHN is important as it associates with significant mortality and morbidities. This review suggests a comprehensive overview of the epide miology, diagnosis, management, prognosis and prevention of MAS.

Meconium aspiration syndrome (MAS) is defined as respiratory distress in newborn infants born through meconium-stained amniotic fluid whose symptoms cannot be otherwise explained. MAS is characterized by hypoxemia, hypercapnia and acidosis that continues to be associated with signifi cant morbidities and mortality. Worldwide, the incidence has declined due to improved obstetric and perinatal care. The pathophysiological mechanism of MAS include perinatal hypoxia, acute airway obstruction, pulmonary and systemic inflammation, surfactant inactivation and persistent pulmonary hypertension of the newborn (PPHN). Respiratory and hemodynamic supports are main therapies for MAS. Early identification and appropriate management of PPHN is important as it associates with significant mortality and morbidities. This review suggests a comprehensive overview of the epide miology, diagnosis, management, prognosis and prevention of MAS.

Meconium aspiration syndrome (MAS) is defined as respiratory distress in newborn infants born through meconium-stained amniotic fluid whose symptoms cannot be otherwise explained. MAS is characterized by hypoxemia, hypercapnia and acidosis that continues to be associated with signifi cant morbidities and mortality. Worldwide, the incidence has declined due to improved obstetric and perinatal care. The pathophysiological mechanism of MAS include perinatal hypoxia, acute airway obstruction, pulmonary and systemic inflammation, surfactant inactivation and persistent pulmonary hypertension of the newborn (PPHN). Respiratory and hemodynamic supports are main therapies for MAS. Early identification and appropriate management of PPHN is important as it associates with significant mortality and morbidities. This review suggests a comprehensive overview of the epide miology, diagnosis, management, prognosis and prevention of MAS.

Food allergy is a rare form of feeding intolerance in preterm infants, with symptoms similar to necrotizing enterocolitis. We report a case of clinically diagnosed cow’s milk-induced eosinophilic enterocolitis in an infant with extremely low birth weight. The patient was born at 24 weeks and 1 day gestation, weighing 610 g, had repeated episodes of gastrointestinal symptoms after feeding, and was placed on nil per os. On day 67, the eosinophil count increased suddenly (7,852.8/mL), and the formula was changed to amino acid-based (Neocate). Gradually, the eosinophil count returned to normal. Ileostomy was performed and full enteral feeding was achieved with Neocate. Intraoperatively, the intestine was nonnecrotic and viable; the biopsy report showed massive mucosal eosinophilic infiltration. The patient was diagnosed with cow’s milk-induced eosinophilic enterocolitis.

Ectopic pancreas is defined as an abnormally located pancreatic tissue not sufficiently connected with the normal pancreas, which rarely occurs in neonates. To our knowledge, only a few cases of ectopic pancreas have been reported in newborns in South Korea. We report a case of ectopic pancreas as the cause of intussusception and jejunal atresia in a newborn. This clinical association is extremely rare, and this is the first report in South Korea.

Ectopic pancreas is defined as an abnormally located pancreatic tissue not sufficiently connected with the normal pancreas, which rarely occurs in neonates. To our knowledge, only a few cases of ectopic pancreas have been reported in newborns in South Korea. We report a case of ectopic pancreas as the cause of intussusception and jejunal atresia in a newborn. This clinical association is extremely rare, and this is the first report in South Korea.

The Diego blood group is expressed as the Di(a) antigen and Di(b) antigen, and the frequency of the Di(a) antigen among the Korean population is estimated to be 9.4~14.5%. We report here on a case of hemolytic disease caused by anti-Di(a) antibody. A full-term male infant was admitted due to hyperbilirubinemia on the first day of life. The total bilirubin level was decreased after phototherapy, but the hemoglobin level was decreased 6.9 g/dL and an exchange transfusion was then performed. The direct antiglobulin test was strongly positive, but the indirect antiglobulin test using screening blood cells without the Di(a) antigen was negative. After we suspected neonatal hemolytic disease caused by the anti-Di(a) antibody, it was confirmed using selected blood cells containing Di(a) antigen. The newborn and father had DI*A/DI*B and the mother had DI*B. The inclusion of Di(a) antigens in an unexpected antibody screening test should be actively discussed in Korea.