STRUCTURAL MANIFESTATION OF THE FUNCTIONAL HIPPOCAMPO-CORTICAL CONNECTIONS IN HUMANS Abstract The human brain is a complex network of interconnected regions that collaborate to support cognitive processes and memory formation. The hippocampus, a crucial hub for episodic memory and spatial navigation, and the cortical areas, responsible for higher-order cognitive functions, are intricately intertwined. These hippocampal-cortical connections suggest that asymmetry in the hippocampal neuronal activity may directly influence the formation of synaptic connections among cortical neurons, thus modulating the processes of neuroplasticity and triggering the formation of cortical functional and morphological asymmetry. This research paper aims to provide a comprehensive overview of the association between hippocampus size and cortical area sizes, shedding light on their synergistic interplay in supporting cognitive processes. Four human brain specimens (2 male, 2 female) were utilized, and the dimensions of the hippocampus and specific cortical gyri were measured using the Einscan H 3D laser scanner. The results revealed asymmetry and variability in sizes across brain regions and hemispheres. Specifically, the right hemisphere exhibited larger hippocampal size compared to the left hemisphere, with the frontal gyri predominantly larger on the right side. Additionally, the right hippocampus showed significant correlations with contralateral inferior and middle frontal gyri, while the left hippocampus displayed pronounced correlations with contralateral middle and superior lateral frontal gyri. The findings highlight the influential role of the hippocampus in shaping cortical area sizes, particularly in the frontal gyri. These results contribute to our understanding of the complex interdependence between the hippocampus and cortical areas, with implications for memory-related disorders and cognitive deficits. Further research is needed to explore the developmental and aging changes in hippocampal-cortical connections and their impact on brain function.