Objective To investigate the inhibitory effects of resveratrol(Res)on the growth of hormone-dependent and castration-resistant prostate cancer(PCa)and explore its mechanisms.Methods Subcutaneous xenograft models were established in nude mice using the human prostate cancer cell lines LNCaP(hormone-sensitive)and its castration-resistant derivative LNCaP-B.Thirty nude mice were randomly divided into three groups:control group,Res-treated and docetaxel.Tumor growth was recorded.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot were performed to assess androgen receptor(AR)mRNA and protein expression levels in tumor tissues.Results Moderate-and high-dose Res significantly inhibited the growth of both LNCaP and LNCaP-B xenografts in a dose-dependent manner,with statistical significance(P<0.05).qRT-PCR and Western blot analyses revealed that Res markedly downregulated AR mRNA expression and protein levels compared to the control group.However,no significant pathological alterations were observed in HE-stained tumor sections.Conclusions Resveratrol suppresses the growth of hormone-dependent and castration-resistant prostate cancer by inhibiting AR expression and signaling pathway activity.These findings highlight its potential as an adju-vant therapeutic agent to androgen deprivation therapy(ADT),providing a theoretical foundation for its clinical application in PCa treatment.

Prostate cancer is one of the common malignant tumors in men.With the aging of the population and the progress of diagnostic technology,its incidence continues to rise.Radical prostatectomy is an effective treatment for localized prostate cancer.However,the incidence of inguinal hernia after surgery is high,which seriously affects patients' postoperative recovery and quality of life.This article provides a systematic review for the pathogenesis of inguinal hernia after prostate cancer surgery,including changes in anatomical structure,scar formation in the retroperitoneal space,no closure of sheath process,and increased intra-abdominal pressure after surgery.It also summarizes the relevant influencing factors,such as surgical methods,patients' own conditions,and postoperative recovery status.On this basis,surgical prevention and treatment strategies are explored,such as intraoperative preventive repair,re-fined surgical procedures,and postoperative targeted treatment.At the same time,future research directions are proposed,focusing on the in-depth exploration of molecular biological mechanisms,research and development of new materials,and application of artificial intelligence technology,aiming to reduce the incidence of inguinal hernia after prostate cancer surgery and improving patients' postop-erative quality of life.

Prostate cancer is one of the common malignant tumors in men.With the aging of the population and the progress of diagnostic technology,its incidence continues to rise.Radical prostatectomy is an effective treatment for localized prostate cancer.However,the incidence of inguinal hernia after surgery is high,which seriously affects patients' postoperative recovery and quality of life.This article provides a systematic review for the pathogenesis of inguinal hernia after prostate cancer surgery,including changes in anatomical structure,scar formation in the retroperitoneal space,no closure of sheath process,and increased intra-abdominal pressure after surgery.It also summarizes the relevant influencing factors,such as surgical methods,patients' own conditions,and postoperative recovery status.On this basis,surgical prevention and treatment strategies are explored,such as intraoperative preventive repair,re-fined surgical procedures,and postoperative targeted treatment.At the same time,future research directions are proposed,focusing on the in-depth exploration of molecular biological mechanisms,research and development of new materials,and application of artificial intelligence technology,aiming to reduce the incidence of inguinal hernia after prostate cancer surgery and improving patients' postop-erative quality of life.

Objective To investigate the inhibitory effects of resveratrol(Res)on the growth of hormone-dependent and castration-resistant prostate cancer(PCa)and explore its mechanisms.Methods Subcutaneous xenograft models were established in nude mice using the human prostate cancer cell lines LNCaP(hormone-sensitive)and its castration-resistant derivative LNCaP-B.Thirty nude mice were randomly divided into three groups:control group,Res-treated and docetaxel.Tumor growth was recorded.Quantitative real-time polymerase chain reaction(qRT-PCR)and Western blot were performed to assess androgen receptor(AR)mRNA and protein expression levels in tumor tissues.Results Moderate-and high-dose Res significantly inhibited the growth of both LNCaP and LNCaP-B xenografts in a dose-dependent manner,with statistical significance(P<0.05).qRT-PCR and Western blot analyses revealed that Res markedly downregulated AR mRNA expression and protein levels compared to the control group.However,no significant pathological alterations were observed in HE-stained tumor sections.Conclusions Resveratrol suppresses the growth of hormone-dependent and castration-resistant prostate cancer by inhibiting AR expression and signaling pathway activity.These findings highlight its potential as an adju-vant therapeutic agent to androgen deprivation therapy(ADT),providing a theoretical foundation for its clinical application in PCa treatment.

Objective To evaluate the efficacy and safety of management of kidney calculi in non-uronephrosis by percutaneous nephrolithotripsy (PCNL) under ultrasound guidance. Methods From July 2005 to June 2008, 97 cases of kidney calculi in non-uronephrosis were performed by percutaneous nephrolithotripsy. A tube was first inserted into the pelvis through cystoscope, and saline was instilled to dilate collecting system. Antegrade percutaneous access was obtained under ultrasound guidance. A combination of pneumatic and ultrasonic lithotrite was used to disintegrate and remove stone under direct vision. Clinical data including operation time, complications and stone free rate were analyzed retrospectively. Results The perutaneous renal access was successfully established under ultrasound guidance in all patients, immediate phase Ⅰ lithotripsy was performed in 95 cases and delayed phase Ⅱ lithotripsy in 2 cases. Operation time was 70-180 min, average time was (96±23 ) min. The average blood loss was 60 ml (20-500 ml), 4 cases had transfusion during the PCNL and average 400 ml. Minor pyrexia ( < 39℃) was seen in 24 cases,whereas serious pyrexia was noted in 3 cases. Conservatively administered with appropriate antibiotics, the fever disapeared in 27 cases within 5 days postoperatively. Severe complications did not occur during nephrolithotripsy. Stones were cleared completely in 78 out of 97 cases (80.4%)during immediate phase Ⅰ lithotripsy, residual stone fragment was found in 19 cases. Conclusion The management of kidney calculi in non-uronephrosis by PCNL appears to be efficacious and safe under ultrasound guidance.