1.Factors associated with work-related musculoskeletal disorders using machine learning approaches: a systematic review
Muhammad Irfan MOHD SALLEHHUDIN ; Siti Munira YASIN ; Mohamad Rodi ISA ; Tajul Rosli RAZAK ; Muhamad Syazni MOHAMAD ASRAFF ; Nur Adilla CHE RAMELI ; Muhammad Muaz SHAHRIMAN-TERUNA ; Muhammad Muzzammil MOHAMAD SALLEH ; Mohamad Zuhair MOHAMED YUSOFF ; Muhammad Hariz AMMAR KHEBIR
Annals of Occupational and Environmental Medicine 2026;38(1):e10-
Background:
Work-related musculoskeletal disorders (WRMSDs) remain a major cause of occupational disability and productivity loss worldwide. Traditional statistical methods have identified numerous associated factors; however, they often struggle to capture complex non-linear relationships and interactions across multiple domains of risk. Machine learning (ML) offers an alternative analytical approach for modelling such multidimensional relationships.
Methods:
Following the PRISMA 2020 guidelines (PROSPERO: CRD420250605234), literature searches were conducted in Web of Science, Scopus, and PubMed for studies published between 2020 and 2025. Eligible studies applied ML methods to identify factors associated with WRMSDs using cross-sectional study designs. Included studies were appraised using the Joanna Briggs Institute Critical Appraisal Checklist for analytical cross-sectional studies.
Results:
Ten studies met the inclusion criteria, representing workers from healthcare, transport, manufacturing, and service sectors across Asia, Africa, and Europe. Frequently applied ML algorithms included random forest, support vector machine, and artificial neural networks, demonstrating strong internal discriminative performance (area under the receiver operating characteristic curve: 0.80–0.99), although the absence of external validation in several studies suggests a potential risk of overfitting. Commonly identified factors included age, sex, awkward posture, vibration exposure, prolonged working hours, stress, and burnout. Psychosocial factors, including post-traumatic stress disorder, job stress, and depression, were ranked among the most influential predictors within ML models.
Conclusions
ML models demonstrate strong capability in discriminating WRMSDs risk and identifying multidimensional risk factors compared with traditional statistical approaches. These models highlight complex interrelationships between ergonomic and psychosocial exposures. Future research should incorporate external validation, objective exposure measurements, and standardized ML reporting frameworks to enhance methodological transparency and generalizability.
2.Gastrointestinal Stromal Tumour Masquerading as a Gynaecological Neoplasm
Akmal Aizat BAKHORI ; Mohd Nizam Md HASHIM ; Mohan A ; Muhammad Taqiyuddin YAHAYA ; Noor Iman Mohd ISA ; Faezahtul Arbaeyah HUSSAIN
Brunei International Medical Journal 2026;22():105-109
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours commonly found in the gastrointestinal tract, particularly in the stomach, but they can mimic gynaecological tumours. We report the case of a 56 -year-old postmenopausal woman who presented with a right adnexal pelvic mass. Computed tomography (CT) revealed a large, lobulated pelvic mass with liver lesions. Pan - endoscopy showed normal findings, and her tumour markers were within normal limits. Based on these findings, the gynaecological oncology team proceeded with a laparotomy and tumour debulking, diagnosing the pelvic mass as likely ovarian in origin. Intraoperatively, the mass was found to originate from the stomach and extend posteriorly to the transverse colon. An en -bloc resection with primary anastomosis was performed and histopathology confirmed a high -risk GIST. The patient made a good post -operative recovery and was scheduled for adjuvant chemotherapy at her follow -up visit. This case highlights the importance of considering GIST as a differential diagnosis in postmenopausal women presenting with an abdominopelvic mass that may mimic an ovarian tumour
3.Gastrointestinal Stromal Tumour Masquerading as a Gynaecological Neoplasm
Akmal Aizat BAKHORI ; Mohd Nizam Md HASHIM ; Mohan A ; Muhammad Taqiyuddin YAHAYA ; Noor Iman Mohd ISA ; Faezahtul Arbaeyah HUSSAIN
Brunei International Medical Journal 2026;22():105-109
Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours commonly found in the gastrointestinal tract, particularly in the stomach, but they can mimic gynaecological tumours. We report the case of a 56 -year-old postmenopausal woman who presented with a right adnexal pelvic mass. Computed tomography (CT) revealed a large, lobulated pelvic mass with liver lesions. Pan - endoscopy showed normal findings, and her tumour markers were within normal limits. Based on these findings, the gynaecological oncology team proceeded with a laparotomy and tumour debulking, diagnosing the pelvic mass as likely ovarian in origin. Intraoperatively, the mass was found to originate from the stomach and extend posteriorly to the transverse colon. An en -bloc resection with primary anastomosis was performed and histopathology confirmed a high -risk GIST. The patient made a good post -operative recovery and was scheduled for adjuvant chemotherapy at her follow -up visit. This case highlights the importance of considering GIST as a differential diagnosis in postmenopausal women presenting with an abdominopelvic mass that may mimic an ovarian tumour
4.A Regression Model of Hip Flexion Force of the Dominant Leg Among Malaysian Adults in Standing Posture
Isa Halim1 ; Zulkeflee Abdullah1 ; Nurul Wirdah Mafazi1 ; Muhammad Nadzirul Izzat Mahadzir1 ; Mohd Shahir Kasim2 ; Adi Saptari3
Malaysian Journal of Medicine and Health Sciences 2025;21(No. 1):91-102
Introduction: The disregard for hip flexion force when designing foot-operated equipment poses a potential threat
to non-compliance with ergonomics principles, ultimately impacting occupational health. Nevertheless, there is a
noticeable lack of studies focusing on the hip flexion strength of Malaysian adults in a standing position. This paper
aimed to measure the maximum force of hip flexion strength and formulate a regression model for Malaysian young
adults in a standing posture. Materials and methods: The experiment invited sixty Malaysian adults aged 20 to 26
years old. A digital force gauge (Mark-10, USA) was used to measure the hip flexion force. A regression model was
developed to determine the influence of gender, body mass, body height, thigh length, and thigh circumference on
the hip flexion force. Results: The results of this study found that the means of hip flexion force for the male and
female participants were 192.8 N and 126.0 N, respectively. The regression model concluded that gender is the
most significant factor influencing hip flexion force (p<0.01). The body mass, body height, thigh length, and thigh
circumference positively correlate to hip flexion force. However, these correlations were not statistically significant
(p>0.05). Conclusion: This study concluded that the relationship between anthropometric parameters and hip flexion
force is not always straightforward and can be influenced by various factors. To gain a more comprehensive picture
of hip flexion, it is essential to consider other potential factors such as muscle mass, neuromuscular control, and joint
mechanics.
5.A Review on Ergonomics Factors Determining Working in Harmony with Exoskeletons
Isa Halim ; Muhammad Nadzirul Izzat Mahadzir ; Zulkeflee Abdullah ; Muhammad Zaimi Zainal Abidin ; Mohd Nazrin Muhammad ; Adi Saptari
Malaysian Journal of Medicine and Health Sciences 2023;19(No.6):311-327
Exoskeletons are wearable devices that can enhance human strength and are used in various fields, such as healthcare and the manufacturing industry. However, poorly designed exoskeletons can strain the muscles and cause injuries to users. The objectives of this review paper are to review the ergonomics factors that contribute to a harmonious
user-exoskeleton interaction and to explore the current trends, challenges, and future directions for developing ergonomically designed exoskeletons. In this review, 102 relevant papers published from 2015 to 2023 were retrieved
from Web of Science, Scopus, and Google Scholar. These papers were considered in the analysis for gathering relevant information on the topic. The authors identified six ergonomics factors, namely kinematic compatibility, contact
pressure, postural control, metabolic cost, cognitive workload, as well as task demands and workplace conditions,
that can influence the interaction between users and exoskeletons. By understanding and addressing these ergonomics factors during the design and development process, exoskeleton designers can enhance the user experience and
adoption of the devices in daily living activities and industrial applications.
6.The Agreement between State-Trait-Anxiety-Inventory (STAI) and Beck Anxiety Inventory (BAI) on Measuring Anxiety Level Among Adult Patients Before Venepuncture Procedure
Izzaty Dalawi ; Mohamad Rodi Isa ; Faizul Haris Mohd Hatta ; Muhammad Fairuz Rahmat
Malaysian Journal of Medicine and Health Sciences 2023;19(No.3):254-261
Introduction: Venepuncture procedure is painful and anxiety associated with venepuncture is common. There are
many tools for assessing anxiety levels in an outpatient setting. Hence, this study is to compare the degree of agreement between State-Trait-Anxiety-Inventory (STAI) and Beck Anxiety Inventory (BAI) for measuring anxiety levels
among adult patients before venepuncture procedure. Methods: A cross-sectional pilot study was conducted among
patients while waiting for a venepuncture procedure in the Phlebotomy Unit, UiTMMC in April 2020. The Malay-validated version of the State-Trait-Anxiety-Inventory (STAI) and Beck Anxiety Inventory (BAI) were used to assess the anxiety level. Differences between sets of data were plotted as described by Bland-Altman to determine the
agreement between these two assessment tools. Results: A total of 330 patients participated in the study with a mean
age of 46.34 ± 14.34 years old and gender was equally distributed. The scores of state-anxiety (STAI-S), trait-anxiety
(STAI-T) and BAI score were 30.04 ± 20.74; 29.51 ± 19.11; and 40.98 ± 20.45, respectively. The score of anxiety
using BAI was higher compared to STAI-S (p<0.001) and STAI-T (p<0.001). The mean difference between the STAI-S
and BAI was -10.94 (95%CI: -53.01, 26.87) and between the STAI-T and BAI was -11.47 (95%CI: -42.26, 19.32).
However, very few patients’ scores outside the 95% LOA for both differences. Conclusion: The STAI and BAI are concordances in measuring anxiety levels among these patients. However, the anxiety score using BAI was higher than
STAI. Thus, both assessment tools can be used in clinical practice in measuring anxiety in the out-patients setting.
7.Evaluation of beak and feather disease virus, avian polyomavirus and avian papillomavirus of captives psittacine birds in Seri Kembangan, Selangor, Malaysia
Muhammad Faiz Mohd Padzil ; Nur Syafiqah Ab Halim ; Nurulhuda Najihah ; Aminuddin Baki Nurul Najian ; Jalila Abu ; Nurulfiza Mat Isa ; Han Yih Lau ; Abdul Razak Mariatulqabtiah
Malaysian Journal of Microbiology 2021;17(3):338-344
Aims:
Psittacine birds such as parrots, macaws, cockatoos, lovebirds and parakeets, are widely reared as household
pets or at aviary due to their attractive features. However, the status of virus-causing diseases of psittacine species in
Malaysia is fairly under-documented. Therefore, this study was aimed to detect the presence of three common avian
viruses that infect psittacine birds, i.e. beak and feather disease virus (BFDV), avian polyomavirus and avian
papillomavirus.
Methodology and results:
Faecal samples from twelve asymptomatic captive psittacine birds of different species were
collected from an undisclosed animal garden in Serdang, Selangor, Malaysia. Briefly, the sample was homogenised and
resuspended with SM buffer with the ratio 1:1 (weight of sample/g: volume of SM buffer/mL) before centrifugation at
1,000 × g for 20 min. The supernatant was collected and filtered before subjected to genomic DNA extraction using a
commercialised kit. Polymerase chain reaction (PCR) technique was used to screen the V1, VP1 and L1 genes of beak
and feather disease virus (BFDV), avian polyomavirus and avian papillomavirus, respectively. Findings revealed that the
samples were negative for BFDV and avian polyomavirus. However, positive results of 1.5 kbp PCR amplicon were
detected for avian papillomavirus in four out of the 12 samples (33.33%), which was from the white-crested cockatoo,
African grey parrot, yellow-collared macaw and Senegal parrot. Sequence analysis of the L1 gene from the Senegal
parrot Poicephalus senegalus revealed 93% identity to a reference Psittacus erithacus timneh avian papillomavirus.
Conclusion, significance and impact of study
This study added to the limited prevalence data of three important
avian viruses which infect captive psittacines in Seri Kembangan, Selangor, Malaysia. Avian papillomavirus, but not
BFDV and avian polyomavirus, was detected in the collected captive psittacine birds. Therefore, a routine screening can
be performed to monitor the health status of birds despite their asymptomatic manifestation, in order to prevent possible
virus transmission.
Virus Diseases
;
Birds
8.Radiation Dose To The Eye And Potential Occurrence Radiation- Induced Cataract Following Computed Tomography (CT) Head Examination
Muhammad Ikhmal Naim Mohd Hilal ; Rekha Ganesan ; orhashimah Norsuddin ; Mohd Izuan Ibrahim ; Said Mohd Shaffiq Said Rahmat ; Muhammad Khalis AbdKarim ; Iza Nurzawani Che Isa
Malaysian Journal of Public Health Medicine 2021;21(2):1-7
The eye is a radiosensitive organ that lies within the scan range during Computed Tomography (CT) of the head. The utilization of the head CT is increasing with growing concern about the chances of development of cataract which induces by ionising radiation. This research aimed to calculate eye absorbed dose and to study the potential occurrence of radiation induces cataracts between CT Brain and CT Temporal. A total of 399 set data were obtained retrospectively according to inclusion and exclusion criteria. 364 patients underwent CT Brain while 35 patients’ data obtained for CT Temporal. The scanning parameters such as tube current, tube potential, pitch factor, beam width, filter, revolution time, and filter were recorded. Eye absorbed dose was significantly different (p<0.05) between CT brain (49.07±10.08mGy) and CT temporal (25.72 ± 6.12mGy). None of the analysed data exceeded the eye threshold dose recommended by ICRP 2012. However, as expected, the cumulative eye absorbed dose was increased as the frequencies of the scan increase. The highest number of repeated scans is five times with cumulative dose was recorded as 278.27mGy. In conclusion, the eye absorbed dose is higher in CT Brain compared to CT Temporal and has potential for induction of cataract in the future especially with the patient that undergoes repeated CT examination.
CT brain
;
CT temporal
;
cataract
9.Associations Between Knowledge on Optimal Control of Serum Phosphate, Perceived Social Support, Dietary Phosphorus Intake and Phosphate Compliance Among Hemodialysis Patients
Muhammad Darwish Asyraf Mohd Isa ; Fiona Jie Wei Lai ; Shen Yi Chong ; Nur Amrina Rasyada Ismail ; Kar Fei Chan ; Yoke Mun Chan
Malaysian Journal of Medicine and Health Sciences 2020;16(Supp 6, Aug):140-147
Introduction: Hyperphosphatemia is common among hemodialysis patients, often accompanies with unfavourable clinical outcomes. Several factors affect phosphate compliance among hemodialysis patients, with lack of such information at the local context. Thus, this cross-sectional study aimed to determine the associations of sociodemographic factors, knowledge on optimal control of serum phosphate, perceived social support from family, dietary phosphorus intake and phosphate compliance among hemodialysis patients. Methods: Structured questionnaire was used to obtain information on socioeconomic factors, knowledge, family social support and dietary phosphorus intakes of hemodialysis patients, with serum phosphate level was used as the surrogate marker for phosphate compliance. Results: A total of 76 patients (Mean age of 52 years old) were recruited. Hyperphosphatemia was prevalent with approximately 60% of the patients failed to achieve the target. Approximately 90% of the patients perceived low level of family social support. Young patients had significant higher serum phosphate compared to their older counterparts (r = -0.297, p =0.009). Serum phosphate was positively correlated with dietary intake of phosphorus, dialysis vintage (r = 0.301, p = 0.006) and comorbidity score (r = 0.325, p = 0.008) while negatively correlated with dialysis dose (r = -0.582, p = 0.002) and family social support (r = -0.263, p = 0.024). Conclusion: The promising role of dietary phosphorus intake in managing hyperphosphatemia deserves further attention. Innovative approaches are needed to promote self-adherence on serum phosphate especially the younger patients. It is imperative to promote family social support in the management of hyperphosphatemia among hemodialysis patients.
10.Characteristics Of Visually Impaired Children Aged Below 4 Years In Two Public Tertiary Hospitals In Selangor, Malaysia
Victor Feizal Knight ; Nurhafizah Muhd Khairi ; Rokiah Omar ; Azura Ramlee ; Muhammad Mohd Isa
Malaysian Journal of Public Health Medicine 2018;18(Special Volume (1)):18-25
The purpose of this study is to determine the prevalence and causes of visually impairment among children below 4 years old in two public tertiary referral hospitals in Selangor, Malaysia. In this cross-sectional retrospective study, the case files of all children aged below 4 years from the ophthalmology clinics in two separate public hospitals in Selangor, Malaysia were analysed over a 5-year period. The definition of visual impairment was based on the World Health Organization (WHO) classification, i.e. moderate visual impairment: visual acuity <6/18 to 6/60 in the better eye; severe visual impairment: <6/60 to 3/60 in the better eye; and blindness: visual acuity <3/60 in the better eye. Prevalence of visual impairment was based on the presenting visual acuity and then differentiated according to the cause of visual impairment diagnosed. A total of 243 (17.38%) children from a total of 1,398 children were classified as visually impaired. Most of these children (n=119, 49.0%) exhibited moderate visual impairment, 26 (10.7%) had severe visual impairment, while 98 (40.3%) were blind. Refractive errors (n=60, 24.7%) were the most common cause of vision impairment, mostly myopes (n=28, 46.7 %). This was followed by strabismus (n=31, 12.8%) and retinopathy of prematurity (n=29, 11.9%). In conclusion, vision impairment was prevalent in children aged below 4 years old presenting to two ophthalmology clinics in a highly urbanised region in Malaysia. High refractive errors were the major cause of vision impairment seen. Our study highlights the need and utmost importance of an early intervention programme to be implemented for these children since the main cause of vision impairment found in this study is an easily treated problem.
visual impairment
;
prevalence
;
children
;
blindness


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