Objective:To construct a maintenance management system based on Total Productive Maintenance(TPM)theory for large-scale medical equipment,and explore its application effect in the management for large-scale medical equipment.Methods:By building TPM management team,predicting equipment's failures,planning TPM management pathway for equipment,and implementing quality control to construct TPM management system for the large-scale medical equipment.A total of 547 large-scale medical equipment that were used in clinical practice at the First Affiliated Hospital of Harbin Medical University from February 2022 to July 2024 were selected.They were divided into conventional management mode(272 equipment)and TPM management mode(275 equipment)by using random number table method.The TPM management mode conducted management on the basis of TPM management system for large-scale medical equipment.The equipment configuration,operational quality,effectiveness of equipment maintenance,and maintenance quality of the two kinds of management modes were compared.Using a self-made satisfaction questionnaire to evaluate the satisfaction of management personnel who used equipment for the service quality of maintenance management of two management modes for medical equipment.Results:The average configuration rate,utilization rate,and operation rate of equipment that using TPM management mode were(4.81±0.94)%,(97.98±0.67)%,and(89.15±4.78)%,respectively,all which were higher than those that using conventional management mode.However,the average failure rate was(1.72±0.12)%,which was lower than that of using conventional management mode.The differences of the above indicators were statistically significant(t=39.942,80.213,23.188,71.723,P<0.05).The average values of the efficiency of equipment maintenance,the standardization of usage,timeliness of maintenance,and pass rate of quality inspection of TPM management mode were all higher than those of conventional management mode,and the differences were statistically significant(t=36.893,22.913,17.948,21.553,P<0.05).The response time,average repair rate of failure,and delivery cycle of accessories of equipment maintenance of TPM management mode were all lower than those of conventional management mode,while the quality score of maintenance service was higher than that of conventional management mode,and the differences were statistically significant(t=37.332,25.116,53.265,55.988,P<0.05).The satisfactions of management personnel who used equipment for preventive maintenance,preventive repair,usage management,fault repair,quality inspection,and post maintenance of equipment that adopted TPM management mode were all higher than those that adopted conventional management mode,and the differences were statistically significant(t=24.218,21.408,19.706,27.141,38.149,46.434,P<0.05).Conclusion:The maintenance management system based on TPM theory for large-scale medical equipment can effectively improve operation efficiency and maintenance quality of equipment,and reduce equipment's failure rate,and enhance the timeliness of maintenance services for equipment,and increase the satisfaction of management personnel in using equipment.

Objective:To construct a maintenance management system based on Total Productive Maintenance(TPM)theory for large-scale medical equipment,and explore its application effect in the management for large-scale medical equipment.Methods:By building TPM management team,predicting equipment's failures,planning TPM management pathway for equipment,and implementing quality control to construct TPM management system for the large-scale medical equipment.A total of 547 large-scale medical equipment that were used in clinical practice at the First Affiliated Hospital of Harbin Medical University from February 2022 to July 2024 were selected.They were divided into conventional management mode(272 equipment)and TPM management mode(275 equipment)by using random number table method.The TPM management mode conducted management on the basis of TPM management system for large-scale medical equipment.The equipment configuration,operational quality,effectiveness of equipment maintenance,and maintenance quality of the two kinds of management modes were compared.Using a self-made satisfaction questionnaire to evaluate the satisfaction of management personnel who used equipment for the service quality of maintenance management of two management modes for medical equipment.Results:The average configuration rate,utilization rate,and operation rate of equipment that using TPM management mode were(4.81±0.94)%,(97.98±0.67)%,and(89.15±4.78)%,respectively,all which were higher than those that using conventional management mode.However,the average failure rate was(1.72±0.12)%,which was lower than that of using conventional management mode.The differences of the above indicators were statistically significant(t=39.942,80.213,23.188,71.723,P<0.05).The average values of the efficiency of equipment maintenance,the standardization of usage,timeliness of maintenance,and pass rate of quality inspection of TPM management mode were all higher than those of conventional management mode,and the differences were statistically significant(t=36.893,22.913,17.948,21.553,P<0.05).The response time,average repair rate of failure,and delivery cycle of accessories of equipment maintenance of TPM management mode were all lower than those of conventional management mode,while the quality score of maintenance service was higher than that of conventional management mode,and the differences were statistically significant(t=37.332,25.116,53.265,55.988,P<0.05).The satisfactions of management personnel who used equipment for preventive maintenance,preventive repair,usage management,fault repair,quality inspection,and post maintenance of equipment that adopted TPM management mode were all higher than those that adopted conventional management mode,and the differences were statistically significant(t=24.218,21.408,19.706,27.141,38.149,46.434,P<0.05).Conclusion:The maintenance management system based on TPM theory for large-scale medical equipment can effectively improve operation efficiency and maintenance quality of equipment,and reduce equipment's failure rate,and enhance the timeliness of maintenance services for equipment,and increase the satisfaction of management personnel in using equipment.

OBJECTIVE: Improve the quality of testing in medical device manufacturers clean workshops to ensure the authenticity and reliability of testing data. METHODS: Analyze the problems and influencing factors found in the process of testing of medical device manufacturers clean workshops from 2016 to 2020, and put forward reasonable suggestions to ensure the quality of testing. RESULTS: In the process of testing, there are six factors that affect the quality of testing, including testing personnel, instruments and equipment, testing consumables, testing methods, testing environment and actual operation. CONCLUSIONS To improve the quality of testing, should strengthen the training of testing personnel, continuously improve the testing quality management system, establish an effective information communication mechanism, find out the influencing factors in time, provide objective, real and effective testing data for medical device manufacturing enterprises, and provide technical support for the production and supervision of medical devices.
Commerce ; Equipment and Supplies ; Reproducibility of Results

In the era of genome-wide association study (GWAS), a large number of drug response-related loci have been identified in the non-coding sequences. The interpretation of these loci in mechanism is concerned with the effects on the mRNA expression level of these genes. Expression quantitative trait loci (eQTL) studies indicate the relationship of genome variants and the level of mRNA. Its elucidation of the relationship between genetic variation and gene expression, gene interaction and gene regulatory network provides an efficacious mean for pharmacogenomics. The effects of gene polymorphism on drug responses have been unraveled thoroughly in studies which combined pharmacogenomics with eQTL and GWAS.

Carcinoma ; Humans ; Limbic Encephalitis ; diagnosis ; surgery ; Male ; Middle Aged ; Nasopharyngeal Neoplasms ; diagnosis ; surgery

Epigenetic abnormalities not only associated with carcinogenesis, they may also influence the curative effect and prognosis of anticancer drugs through modifying pharmacokinetic genes related to drug absorption, distribution, metabolism, excretion and pharmacodynamic genes related to signaling pathways and targets. That drugs through regulating epigenetic factors pocessing anti-cancer effect is becoming a research hot spot. We summarized and analyzed the realtionship of DNA methylation, miRNA, and histone modification with antitumor drug effect, aiming at promoting rational use of antitumor drugs and providing new ideas on developing epi-drugs.
Antineoplastic Agents ; therapeutic use ; DNA Methylation ; Epigenesis, Genetic ; Histones ; genetics ; metabolism ; Humans ; MicroRNAs ; metabolism ; Neoplasms ; drug therapy ; genetics