Retinal detachment(RD)is defined as a separation between the neuroepithelial layer and the pigment epi-thelial layer of the retina,which is a serious ophthalmologic emergency that,if left untreated,may lead to permanent vision loss.Thus,the study of its treatment is of great importance.Current treatments include laser photocoagulation,pneumatic retinal fixation,scleral buckling,and vitrectomy,etc.With the advancement of minimally invasive surgical techniques,minimally invasive vitrectomy has become an important treatment.The development of smaller-diameter instruments such as 23 G,25 G,and 27 G has helped reduce surgical trauma by decreasing the size of the surgical incision in minimally inva-sive surgeries,improving surgical safety and effectiveness.At the same time,tissue engineering has emerged as a promising technique in retinal repair,especially in the application of biomaterials and the research of cell therapy.Although research-ers have achieved promising results currently,there are still some challenges,such as the biocompatibility of biomaterials,the effectiveness of cell therapy,and the evaluation of long-term efficacy.Therefore,the purpose of this article is to review the current status of the application of minimally invasive techniques and tissue engineering in the treatment of retinal de-tachment,to discuss their potential advantages,limitations,and trends in their integration,and to look into the future di-rection of development to provide guidance for clinical practice.

Retinal detachment(RD)is defined as a separation between the neuroepithelial layer and the pigment epi-thelial layer of the retina,which is a serious ophthalmologic emergency that,if left untreated,may lead to permanent vision loss.Thus,the study of its treatment is of great importance.Current treatments include laser photocoagulation,pneumatic retinal fixation,scleral buckling,and vitrectomy,etc.With the advancement of minimally invasive surgical techniques,minimally invasive vitrectomy has become an important treatment.The development of smaller-diameter instruments such as 23 G,25 G,and 27 G has helped reduce surgical trauma by decreasing the size of the surgical incision in minimally inva-sive surgeries,improving surgical safety and effectiveness.At the same time,tissue engineering has emerged as a promising technique in retinal repair,especially in the application of biomaterials and the research of cell therapy.Although research-ers have achieved promising results currently,there are still some challenges,such as the biocompatibility of biomaterials,the effectiveness of cell therapy,and the evaluation of long-term efficacy.Therefore,the purpose of this article is to review the current status of the application of minimally invasive techniques and tissue engineering in the treatment of retinal de-tachment,to discuss their potential advantages,limitations,and trends in their integration,and to look into the future di-rection of development to provide guidance for clinical practice.

Objective To compare the clinical effects between sutureless bridge intrascleral fixation and ciliary sul-cus suture suspension of intraocular lens(IOL)1 year postoperatively.Methods In this retrospective study,14 patients(14 eyes)who underwent sutureless bridge intrascleral IOL fixation in the No.988 Hospital of Joint Logistic Support Force of PLA from March 2019 to January 2022 were taken as the intrascleral fixation group and 15 patients(15 eyes)who under-went IOL ciliary sulcus suture suspension in the same period were taken as the suture suspension group.During the 1-year follow-up,the preoperative and postoperative uncorrected visual acuity(UCVA),best corrected visual acuity(BCVA)(logMAR),spherical equivalent(SE),endothelial cell count(ECC),intraocular pressure(IOP)and IOL position were compared between the two groups.Results At 1,6 and 12 months postoperatively,the UCVA in both groups significant-ly increased compared with those before surgery(all P＜0.05),and UCVA in the intrascleral fixation group were better than those in the suture suspension group at all postoperative time points(F=4.560,6.411 and5.373;all P＜0.05).At 1,6 and 12 months postoperatively,there was no significant difference in BCVA in both groups compared with those before surgery(all P＞0.05),but BCVA in the intrascleral fixation group were better than those in the suture suspension group at all postoperative time points(F=6.170,6.957 and 10.624;all P＜0.05).After surgery,eyes in the intrascleral fixation group showed hyperopia drift,while eyes in the suture suspension group showed myopia drift.At 1,6 and 12 months post-operatively,the SE of the intrascleral fixation group were(0.59±0.30)D,(0.57±0.27)D and(0.64±0.29)D,respec-tively,and those of the suture suspension group were(-0.75±0.44)D,(-0.72±0.42)D and(-1.12±0.64)D,re-spectively.At 6 months postoperatively,the ECC of both groups were significantly lower than those before surgery(t=8.579 and 21.929;both P＜0.001).The IOP in both groups were within the normal range preoperatively and stable during the follow-up.The IOL were centrally located without obvious decentration or tilt during the follow-up.In addition,there were no vitreous and retinal complications.Conclusion Both sutureless bridge intrascleral IOL fixation and IOL ciliary sulcus suture suspension can obtain a favorable prognosis of visual acuity with refractive shift,while sutureless bridge in-trascleral fixation shows better clinical outcomes.