1.Urticaria Pigmentosa Treated with Antihistamine in a Mixed Cat
Rahye KANG ; Moonseok JANG ; Wanghui LEE ; Seongjun PARK
Journal of Veterinary Clinics 2024;41(6):411-415
A six-month-old, intact female, 1.18 kg mixed-breed cat was referred because of severe pruritus and an erythematous lesion on both ear margins. The referring veterinarian prescribed systemic antibiotic treatments, including Cephalexin at a dosage of 20 mg/kg twice daily for five days, Doxycycline at 5 mg/kg twice daily for two weeks, and Metronidazole at 10 mg/kg twice daily for two weeks, along with oral prednisolone at 0.5 mg/kg twice daily for five days. However, no improvement was observed. Surgical excision of bilateral ear margins did not help with a resolution. The clinical examination revealed a papulocrustous lesion on the ear pinna and a left medial hind limb. The left popliteal lymph node was slightly enlarged. The cytological samples from the skin lesions on the ear margin and left medial hind limb confirmed a secondary bacterial infection.The cytology of the lymph node revealed neutrophilic lymphadenitis. A skin biopsy was performed on both the right ear margin and the left medial hind limb under sedation. The histopathological examination showed moderate perivascular diffuse infiltrate of well-differentiated, non-malignant featured mast cells with neutrophils and eosinophils in the dermis. A definitive diagnosis of urticaria pigmentosa was made based on the clinical signs and histopathological results. The cat was administrated cetirizine (1.7 mg/kg) once daily. Evident improvement was noted after two weeks of treatment. The same treatment was continued for seven days, resulting in complete remission. No relapse occurred after the medication was withdrawn.
2.Adjunctive Therapy of Pimecrolimus for Treatment of Facial Discoid Lupus Erythematosus in a Dog
Yeonhoo JUNG ; Moonseok JANG ; Rahye KANG ; Wanghui LEE ; Seongjun PARK
Journal of Veterinary Clinics 2024;41(1):49-53
A two-year-old, spayed female, 22.5 kg Pungsan was referred with chronic crusts and erosion on the nose. A referring veterinarian prescribed an anti-inflammatory dose (0.5-1 mg/kg/day) of oral glucocorticoids for 5 months, but skin lesions showed no meaningful improvement. A dermatological evaluation revealed a crust, depigmentation, erosion, and erythematous lesion over the nasal planum with a loss of the normal cobblestone texture. Also, firm and multifocal plaques over the thigh, groin, axilla, and dorsum were detected. A cytology examination on the nose, thigh, groin, axilla, and dorsum revealed moderate neutrophilic inflammation and bacterial infection. Abdominal radiography and ultrasonography revealed subcutaneous calcified materials along the thigh, groin, axilla, and dorsum. Calcinosis cutis was suspected because of the adverse effect of previous prolonged corticosteroid therapy. A histopathology examination of the nose lesion revealed moderate to severe degenerative or apoptotic changes of the basal layer and lymphoplasmacytic interface dermatitis. Facial discoid lupus erythematosus (FDLE) was diagnosed based on the history and the clinical, cytological, and histopathological results. Minocycline (7 mg/kg PO q 12 h) and niacinamide (500 mg/dog PO q 12 h) were prescribed as initial treatment.Glucocorticoids were not administered due to the presence of calcinosis cutis induced by previous corticosteroid treatment. After 6 weeks of treatment, the clinical signs on the nose were mildly improved. At this time, topical 1% pimecrolimus cream (twice daily) was initiated, while minocycline and niacinamide were continued at the same dose. The nasal planum markedly improved after 6 weeks of additional treatment, hence minocycline and niacinamide were prescribed for an additional 2 weeks and stopped, and the patient was continued solely on topical pimecrolimus. The dog’s skin lesion has been maintained in clinical remission with topical 1% pimecrolimus twice daily for more than 5 months.
3.A Study on the Name of “Po Goo Nyo Goan†and Its Marking
Heejae LEE ; Moonseok KANG ; Ivo KWON
Korean Journal of Medical History 2019;28(3):685-720
This study aims to correct the Chinese characters of 普救女館 (Po Goo Nyo Goan) and its Korean pronunciation by re-examining the circumstances around the establishment of this hospital, and to discover its naming principle which is associated with the Confucian political philosophy of the Joseon Dynasty. Although 普救女館 is the first modern women's hospital in Korea, most historical studies of this institute have been conducted on limited documents and records. Many published studies use the incorrect names in many ways, so the correct name of the hospital is still in confusion.普救女館, however, was named with four or five of the Chinese characters given by the Joseon government (King Gojong (高宗)) at the time of its establishment. The Joseon government gave the name of Seonnyeoboguwon (善女普救院) to the first modern women's hospital established by Mary Scranton, the name of which was changed to 普救女館.Some records left by the female missionary doctors who worked in 普救女館 show the romanization and meaning of the name of the hospital. The romanization of 普救女館 clarified the Korean pronunciation of “女 (nyeo)†at that time. English translation name of the hospital has always shown that the place provided “extensive†medical treatment to women. It proves the fact that the first Chinese character of the name is “普â€, not “ä¿â€ which is expressed in many documents today.The hospital was named according to Confucian ideals just like the other modern hospitals established around the same time, such as Jejungwon (濟衆院), Gwangjewon (廣濟院), Gwanghyeyeowon (å»£æƒ å¥³é™¢). The Joseon government commonly used similar Chinese characters during the naming of these hospitals, characters that imply the ideal of the good Confucian king's favor for many people of Joseon. 普救女館 was unique in having the character “館(gwan)†in its name, not “院(won)†as in other hospitals. It seems to stem from the characteristic of “women's hospital.†Po Gu Nyo Goan, the unprecedented women's hospital, was probably imagined as a hospitable accommodation where women provided kindness to people in need. This may have been the reason why “館â€, which has the meaning of accommodation, was chosen instead of “院†that primarily meant medical facilities.Correcting the name of 普救女館 helps to eliminate the confusion in current historiography and to promote the understanding of the historical significance of this hospital.

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