Soil-transmitted helminth (STH) infestations are among the most prevalent neglected tropical diseases, especially in low- and middle-income countries. Helminth co-infestations are not uncommon in countries with a high prevalence of STH. We report a case of a 29 -year-old lady with mental retardation and learning difficulties who presented with severe hypochromic microcytic anaemia and severe malnutrition, and diagnosed with concomitant Trichuris trichiura and Ancylostoma duodenale infestations. STH infestations can cause prolonged morbidity, but in our patient, infestations had led to complications of malnutrition and severe weight loss, thus inevitably leading to death.