1.ACHROMOBACTER XYLOSOXIDANS BACTEREMIA IN A CHILD WITH X- LINKED AGAMMAGLOBULINEMIA
Mohammad Qazreen AHMAD SHAWALUDIN ; Mariana DAUD ; Fazila MAT ARIFIN ; Ilie Fadzilah HASHIM ; Zarina Thasneem ZAINUDEEN ; Adiratna MAT RIPEN ; Fahisham TAIB ; Intan Juliana ABD HAMID
Brunei International Medical Journal 2023;19():26-30
X-linked agammaglobulinaemia (XLA) is caused by mutation of the BTK gene. Early immunological screening is important in children with recurrent infection to avoid delay in diagnosis and treatment. A 9-year-old boy with delayed XLA diagnosis presented with a history of recurrent sinopulmonary infection since the age of 1 year old. He had a severe Achromobacter xylosoxidans bacteraemia at the age of 8 years that was successfully treated with intravenous antibiotics. Further immunological screening and genetic testing confirmed the diagnosis of XLA and he was treated with intravenous immunoglobulin replacement therapy. This case provides a valuable information on the diagnosis, treatment and management of XLA, emphasising the importance of early immunological investigations to avoid diagnostic delay.
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