Objective To explore the mediating role of stress-is-enhancing mindset in the relationship between perceived organizational support and job burnout among college mental health teachers. Methods A total of 361 college mental health teachers were selected as the study subjects using the convenience and snowball sampling methods. The Perceived Organizational Support Scale, Stress Mindset Scale, and Maslach Burnout Inventory were used to assess their perceived organizational support, stress-is-enhancing mindset, and job burnout level, respectively. Results The median (25th, 75th percentiles) scores for perceived organizational support, stress-is-enhancing mindset, and job burnout of teachers were 4.1 (3.4,5.1), 2.0 (1.9,2.4), and 1.2 (0.9,1.4), respectively. The detection rate of job burnout was 15.5%. Both perceived organizational support and stress-is-enhancing mindset of the participa were negatively correlated with job burnout [Spearman's rank correlation coefficient (r_S) was -0.40 and -0.45; all P<0.01], while perceived organizational support was positively correlated with stress-is-enhancing mindset (r_S = 0.25, P<0.01). The stress-is-enhancing mindset partially mediated the relationship between perceived organizational support and job burnout, with an effect size of -0.95 (95% confidence interval: -1.55 to -0.47), accounting for 28.0% of the total effect. Conclusion Stress-is-enhancing mindset plays a mediating role between perceived organizational support and job burnout among college mental health teachers.

BACKGROUND: This study aimed to investigate programmed death-ligand 1 tumor proportion score in predicting the safety and efficacy of PD-1/PD-L1 antibody-based therapy in treating patients with advanced non-small cell lung cancer (NSCLC) in a real-world setting. METHODS: This retrospective, multicenter, observational study enrolled adult patients who received PD-1/PD-L1 antibody-based therapy in China and met the following criteria: (1) had pathologically confirmed, unresectable stage III-IV NSCLC; (2) had a baseline PD-L1 tumor proportion score (TPS); and (3) had confirmed efficacy evaluation results after PD-1/PD-L1 treatment. Logistic regression, Kaplan-Meier analysis, and Cox regression were used to assess the progression-free survival (PFS), overall survival (OS), and immune-related adverse events (irAEs) as appropriate. RESULTS: A total of 409 patients, 65.0% ( n = 266) with a positive PD-L1 TPS (≥1%) and 32.8% ( n = 134) with PD-L1 TPS ≥50%, were included in this study. Cox regression confirmed that patients with a PD-L1 TPS ≥1% had significantly improved PFS (hazard ratio [HR] 0.747, 95% confidence interval [CI] 0.573-0.975, P = 0.032). A total of 160 (39.1%) patients experienced 206 irAEs, and 27 (6.6%) patients experienced 31 grade 3-5 irAEs. The organs most frequently associated with irAEs were the skin (52/409, 12.7%), thyroid (40/409, 9.8%), and lung (34/409, 8.3%). Multivariate logistic regression revealed that a PD-L1 TPS ≥1% (odds ratio [OR] 1.713, 95% CI 1.054-2.784, P = 0.030) was an independent risk factor for irAEs. Other risk factors for irAEs included pretreatment absolute lymphocyte count >2.5 × 10 9 /L (OR 3.772, 95% CI 1.377-10.329, P = 0.010) and pretreatment absolute eosinophil count >0.2 × 10 9 /L (OR 2.006, 95% CI 1.219-3.302, P = 0.006). Moreover, patients who developed irAEs demonstrated improved PFS (13.7 months vs. 8.4 months, P <0.001) and OS (28.0 months vs. 18.0 months, P = 0.007) compared with patients without irAEs. CONCLUSIONS A positive PD-L1 TPS (≥1%) was associated with improved PFS and an increased risk of irAEs in a real-world setting. The onset of irAEs was associated with improved PFS and OS in patients with advanced NSCLC receiving PD-1/PD-L1-based therapy.
Humans ; Carcinoma, Non-Small-Cell Lung/metabolism* ; Male ; Female ; Retrospective Studies ; Middle Aged ; Lung Neoplasms/metabolism* ; Aged ; B7-H1 Antigen/metabolism* ; Programmed Cell Death 1 Receptor/metabolism* ; Adult ; Aged, 80 and over ; Immune Checkpoint Inhibitors/therapeutic use*

Objective: To explore the possible latent classes and transition characteristics of medical freshmen and their relationship with social support and mental resilience, so as to provide a scientific reference for preventive education. Methods: A total of 1 155 medical freshmen were cluster random sampled from 3 medical universities in Fujian Province and received 2 rounds of surveys(T1, October 2022; T2, December 2022) by applying Student Adaptation to College Questionnaire, Child and Adolescent Social Support Scale and Connor-Davidson Resilience Scale. And the relevant data was analyzed by using latent profile analysis, latent transition analysis and multiple Logistic regression. Results: There were three different subgroups of school adjustment at two time points for T1 and T2, including high school adjustment group (34.0%, 19.8%), mild school adjustment group (60.5%, 53.8%) and low school adjustment group (5.5%, 26.4%). The low school adjustment group, relatively stable, had the greatest probability of remaining in the same group(94.0%). The high school adjustment group tended to change to mild school adjustment group(25.0%), and the mild school adjustment group tended to change to low school adjustment group (22.0%). Affected by social support, high school adjustment group was less likely to transfer to be mild school adjustment group (OR=0.40) and low school adjustment group (OR=0.26). The mild school adjustment group was prone to transfer to be high school adjustment group (OR=1.47), and less likely to be low school adjustment group (OR=0.58). Influenced by mental resilence, high school adjustment group was less likely to transfer to be mild school adjustment group (OR=0.20) and low school adjustment group (OR=0.13). The mild school adjustment group was prone to transfer to be high school adjustment group (OR=9.17), and less likely to be low school adjustment group (OR=0.42). The low school adjustment group was more likely to transfer to be high school adjustment group(OR=5.43)(P<0.05). Conclusions There are three subgroups of school adjustment in medical freshmen, and class transition in school adjustment are at higher risk and are influenced by social support and mental resilience. The social support and resilience of medical freshmen should be enhanced to promote the school adjustment.