The rapid advancement of digital dentistry has enabled the integration of digital technologies into full-mouth rehabilitation, improving communication between clinicians and dental technicians while greatly enhancing treatment efficiency.This case report details the treatment of a patient with severe tooth erosion and wear, where full-mouth rehabilitation with an increase in vertical dimension was planned. Four digital tools‒an intraoral scanner, facial scanner, T-scan, and Jaw Motion Analyzer‒were used to collect and integrate data, which were then utilized to create a virtual patient through CAD software for the design and fabrication of the prosthesis. The effective use of these digital technologies supported the achievement of a stable occlusion and resulted in both functional and esthetic outcomes. This case demonstrates the effectiveness of a digital workflow in enhancing the accuracy and efficiency of the treatment process, producing clinically satisfactory results.

The rapid advancement of digital dentistry has enabled the integration of digital technologies into full-mouth rehabilitation, improving communication between clinicians and dental technicians while greatly enhancing treatment efficiency.This case report details the treatment of a patient with severe tooth erosion and wear, where full-mouth rehabilitation with an increase in vertical dimension was planned. Four digital tools‒an intraoral scanner, facial scanner, T-scan, and Jaw Motion Analyzer‒were used to collect and integrate data, which were then utilized to create a virtual patient through CAD software for the design and fabrication of the prosthesis. The effective use of these digital technologies supported the achievement of a stable occlusion and resulted in both functional and esthetic outcomes. This case demonstrates the effectiveness of a digital workflow in enhancing the accuracy and efficiency of the treatment process, producing clinically satisfactory results.

The rapid advancement of digital dentistry has enabled the integration of digital technologies into full-mouth rehabilitation, improving communication between clinicians and dental technicians while greatly enhancing treatment efficiency.This case report details the treatment of a patient with severe tooth erosion and wear, where full-mouth rehabilitation with an increase in vertical dimension was planned. Four digital tools‒an intraoral scanner, facial scanner, T-scan, and Jaw Motion Analyzer‒were used to collect and integrate data, which were then utilized to create a virtual patient through CAD software for the design and fabrication of the prosthesis. The effective use of these digital technologies supported the achievement of a stable occlusion and resulted in both functional and esthetic outcomes. This case demonstrates the effectiveness of a digital workflow in enhancing the accuracy and efficiency of the treatment process, producing clinically satisfactory results.

The rapid advancement of digital dentistry has enabled the integration of digital technologies into full-mouth rehabilitation, improving communication between clinicians and dental technicians while greatly enhancing treatment efficiency.This case report details the treatment of a patient with severe tooth erosion and wear, where full-mouth rehabilitation with an increase in vertical dimension was planned. Four digital tools‒an intraoral scanner, facial scanner, T-scan, and Jaw Motion Analyzer‒were used to collect and integrate data, which were then utilized to create a virtual patient through CAD software for the design and fabrication of the prosthesis. The effective use of these digital technologies supported the achievement of a stable occlusion and resulted in both functional and esthetic outcomes. This case demonstrates the effectiveness of a digital workflow in enhancing the accuracy and efficiency of the treatment process, producing clinically satisfactory results.

The rapid advancement of digital dentistry has enabled the integration of digital technologies into full-mouth rehabilitation, improving communication between clinicians and dental technicians while greatly enhancing treatment efficiency.This case report details the treatment of a patient with severe tooth erosion and wear, where full-mouth rehabilitation with an increase in vertical dimension was planned. Four digital tools‒an intraoral scanner, facial scanner, T-scan, and Jaw Motion Analyzer‒were used to collect and integrate data, which were then utilized to create a virtual patient through CAD software for the design and fabrication of the prosthesis. The effective use of these digital technologies supported the achievement of a stable occlusion and resulted in both functional and esthetic outcomes. This case demonstrates the effectiveness of a digital workflow in enhancing the accuracy and efficiency of the treatment process, producing clinically satisfactory results.

The hygiene hypothesis, first proposed in 1989, suggested that reduced exposure to infections in early life leads to allergic diseases by the defects in the establishment of immune tolerance. Although many studies provided evidence that some exposure conditions, including family size, antibiotics, probiotics, and viral or bacterial infections, are strongly related to the prevalence of allergic diseases, thereby supporting the hygiene hypothesis, some evidence does not provide acceptable results for the hygiene hypothesis. Further, most studies have focused on patients with asthma or atopic dermatitis, not allergic rhinitis. In this review, we summarize the recent studies for and against the ‘hygiene hypothesis’ and identify causal association with the prevalence of allergic rhinitis.

We aimed to characterize the genomes of monkeypox virus isolates from the Far East, providing insights into viral transmission and evolution. Genomic analysis was conducted on 8 isolates obtained from patients with monkeypox virus disease in the Republic of Korea between May 2022 and early 2023. These isolates were classified into Clade IIb. Distinct lineages, including B.1.1, A.2.1, and B.1.3, were observed in 2022 and 2023 isolates, with only the B.1.3 lineage detected in six isolates of 2023. These genetic features were specific to Far East isolates (the Republic of Korea, Japan, and Taiwan), distinguishing them from the diverse lineages found in the Americas, Europe, Africa, and Oceania. In early 2023, the prevalence of the B.1.3 lineage of monkeypox virus identified in six patients with no overseas travel history is considered as an indicator of the potential initiation of local transmission in the Republic of Korea.

Purpose: Despite enzyme replacement therapy (ERT) and/or allogeneic hematopoietic stem cell transplantation, individuals with mucopolysaccharidosis (MPS) I or II often experience significant growth deficiencies. This study aimed to assess the safety and efficacy of recombinant human growth hormone (hGH) treatment in children diagnosed with MPS I or II. Materials and Methods: A total of nine pediatric patients—four with MPS I and five with MPS II—underwent treatment with ERT and hGH at Samsung Medical Center. Results: The mean hGH dose administered was 0.26±0.03 mg/kg/week. In the MPS I group, three patients showed an increase in height Z-score from –4.09±0.83 to –3.68±0.43 after 1 year of hGH treatment, and to –3.10±0.72 by the end of the hGH regimen. In the MPS II group, while the height Z-score of four patients decreased according to standard growth charts, it improved from 1.61±1.79 to 2.71±1.68 based on the disease-specific growth chart through hGH treatment. Two patients discontinued hGH treatment due to lack of efficacy after 22 and 6 months each of treatment, respectively. No new-onset neurological symptoms or necessity for prosthetic or orthopedic surgery were reported during hGH treatment. Conclusion This study provides insights into the impact of hGH on MPS patients, demonstrating its potential to reverse growth deceleration in some cases. Further research is needed to explore the long-term effects of hGH on changes in body composition, muscle strength, and bone health in this population.

Allergic rhinitis (AR) is a type of rhinitis accompanied by sensitization to allergens. One of the most clinically important allergens is pollen. Recently, due to climate change and CO 2 air pollution, the flowering period starts earlier and persists longer. In addition, antigenicity due to environmental pollution is also being strengthened. As a result, the sensitization rate to pollen antigens is on the rise. It is known that the prevalence of AR especially caused by pollen is rapidly escalating. Although the causal relationship between pollen exposure and the severity of rhinitis is not precisely established, an association of rhinitis symptoms with the time of pollen scattering exists. In addition, the mixed effect of environmental pollution and pollen may play a role in the development of rhinitis symptoms. Therefore, in order to avoid pollen, it is necessary to constantly improve pollen forecast and minimize the contact with pollen indoors and outdoors. Treatment of AR should be performed according to guidelines. Also, continuous efforts to solve the environmental problems affecting the ecology of pollen are needed.

Coffin-Lowry syndrome (CLS, OMIM # 303600) is a rare X-linked disorder caused by mutations in RPS6KA3. CLS is characterized by facial dysmorphism, digit abnormalities, developmental delays, growth retardation, and progressive skeletal changes in male patients. Females with CLS are variably affected, complicating diagnosis. Here, we describe the clinical and molecular findings in a female Korean child with CLS and review the associated literature. A 5-year-old girl presented with short stature and developmental delays. She had a coarse facial appearance characterized by a prominent forehead, hypertelorism, thick lips, and hypodontia. She also had puffy tapering fingers and pectus excavatum. We performed exome sequencing and identified a novel, likely pathogenic, heterozygous variant, c.326_338delinsCTCGAGAC (p.Val109Alafs*10), in RPS6KA3 (NM_004586.2). This is the first Korean female genetically diagnosed with CLS. In contrast to the delayed bone age reported in previous studies, our patient showed advanced bone age and central precocious puberty. CLS should be considered as a differential diagnosis of short stature, tapering fingers, and developmental delay. We suggest that molecular techniques can be a useful tool for diagnosis of rare disorders such as CLS because such conditions are not simple, and the associated spectrum of phenotypes can vary.