Lysosomal associated protein transmembrane 4 B (LAPTM4B) is a recently discovered gene with the characteristics of oncogenes. This article presents a preliminary review of the structure, biological function and genetic polymorphisms of LAPTM4B and its role in cancer prognosis.

The studies on the antihypoxia mechanism of 18?-SGA were reported. The survival time of hypoxia mice were longer than those of the control after intraperitoneal injections of 14mg/kg or 21mg/kg of 18?-SGA ( Sodium 18?-glycyrrenetic acid). Changes of various physiological indications after administration of the drug were as follows: blood pH was risen; acidosis was relieved; and the partial pressure of oxygen in the mixed blood was decreaed. The blood thyroxine level remain unchanged. It suggests the utilization of oxygen by the tissues was strengthened.