Objective To investigate the relationship between the serum levels of CXC domain chemokine ligands(CXCLs)and CC domain chemokine ligands(CCLs)and occurrence of pulmonary infection in patients with bronchial asthma and the occurrence of pulmonary infection,as well as their predictive value.Methods A total of 288 patients with bronchial asthma in this hospital from March 2020 to May 2024 were selected as the research subjects.According to whether the patients had secondary pulmonary infection,they were divided into the non-pulmonary infection group(n=217)and the secondary pulmonary infection group(n=71).The differences in general clinical data and the expression profile levels of serum C-reactive protein(CRP),procal-citonin(PCT),CXCLs,and CCLs between the two groups of patients were detected and compared.Univariate and multivariate Logistic regression analyses were used to screen out the risk factors related to secondary pul-monary infection in patients with bronchial asthma,and the efficacy of the combined prediction of each risk factor for secondary pulmonary infection in patients with bronchial asthma was evaluated through the receiver operating characteristic(ROC)curve.Results The age,duration of antibacterial drug use,the proportion of patients applying glucocorticoids,and the proportion of patients receiving mechanical ventilation in the second-ary pulmonary infection group were all significantly longer or higher than those in the non-pulmonary infec-tion group(P＜0.05).The levels of serum CRP,PCT,CXCL5,CXCL10,CXCL13,CCL3,CCL5,CCL19 and CCL21 in the secondary pulmonary infection group were significantly higher than those in the non-pulmonary infection group(P＜0.05).Univariate and multivariate Logistic regression analyses revealed that serum CX-CL5,CXCL10,CXCL13,CCL3,CCL5,CCL19,and CCL21 were all important risk factors for secondary pulmo-nary infection in patients with bronchial asthma(P＜0.05).ROC curve analysis revealed that the independent and combined efficacy of serum CXCL5,CXCL10,CXCL13,CCL3,CCL5,CCL19,and CCL21 levels in predic-ting secondary pulmonary infections in patients with bronchial asthma was relatively high,among which the efficacy of the combined prediction was greater than that of the independent prediction of each index(P＜0.05).Conclusion The expression profile levels of serum CXCLs and CCLs in patients with bronchial asthma are correlated with secondary pulmonary infections.The combined prediction model based on the above indica-tors has a high predictive efficacy for secondary pulmonary infections in patients with bronchial asthma.

BACKGRoUND:The clinical manipulation properties of light-cured composite resin,such as flowing property.filling capacity,shaping and stability has not unified definition in dental materials notwithstanding more studies of rheological behaviors were undertook.OBJECTIVE:To explore the dynamic viscoelasticity difference of unpolymerized light.cured composite resins with retentive filler or normal filler,and to investigate effect on the clinical manipulation properties of rheological behaviors in two light-cured composite resins to define an ideal resin.DESIGN,TIME AND SETTING:This controlled study is a correlation study of integrating the base study and clinical use.Basic study was performed in January 2003 at Key Laboratory of Engineering Plastics of Chinese Academy of Sciences in Beijing.The clinical observation study was conducted at the Stomatology Center,Haikou People's Hospital until December 2006.MATERIALS:Light-cured composites employed in this study were reinforced with RF(experimental composite resin I,ECR-Ⅰ)or NF(experimental composite resin Ⅱ,ECR-Ⅱ),which were supplied by Dental Materials Laboratory.Medical College of Stomatology of Peking University.They contained different types of fillers,but had the same resin matrix and volume percent of filler.METHODS:The dynamic viscoelastic properties of ECR-Ⅰ or ECR-Ⅱ were measured respectively with the dynamic stress rheometer DSR-200 in a room maintained 25℃.Flowing property,filling capacity,shaping and stability property were employed to assess the clinical manipulation property of ECR.MAIN OUTCOME MEASURES:Viscoelasticity(G',G",tan δ)and clinical manipulation of two kinds of compound resins.RESULTS:The dynamic viscoelastic behavior of the two composites was sensitive to changes in frequency.ECR-Ⅰhad significantly higher G'than ECR-Ⅱ.ECR-Ⅰ had a greater ability of stability and shaping.and a lower potential for deformation clinically.ECR-Ⅱ had significantly higher G"than ECR-Ⅰ.and ECR-Ⅱ had a higher flowing ability clinically.ECR-Ⅱ had significantly higher tan δ than ECR-Ⅰ.ECR-Ⅱ was found to be more viscous and better filling capacity,with a good adaptation to the cavity of the tooth clinically.CONCLUSION:The dynamic viscoelasticity(G',G",tan δ)and clinical manipulation properties of ECR-ⅠI or ECR-Ⅱ are compared.The ideal composites should have higher G'and lower tan δ