[Objective]To explore the prevention and treatment of type-2 diabetes(T2DM)secondary to depression by using classical formulas,based on the theory of"thirst induced by depression"as described in the Huangdi Neijing,and systematically review relevant texts in traditional Chinese medicine literature.[Methods]Utilizing the"thirst induced by depression"theory from the Huangdi Neijing,this study employs literature research to analyze ancient texts such as Jingui Yaolue,Zhubing Yuanhou Lun and Shennong Bencao Jing for theoretical support regarding the causes,pathogenesis and transmission of depressive syndromes and consumption disorders.This foundation allows for an exploration of the mechanisms through which depressive syndromes lead to consumption and the therapeutic strategies for managing T2DM secondary to depression in clinical practice.Finally,a test case was attached to support it.[Results]The concept of"Yin syndrome"characterized by"weakened organ Qi"shares a common pathological basis with"consumption",particularly during the"weakened five organs"stage.The pathological progression is similar to that seen in the development of T2DM secondary to depression.Specifically,the"Yin syndrome"associated with"weakened organ Qi"may evolve into a consumption syndrome due to prolonged Qi stagnation and increasing heat.Therefore,based on the pathological sequence of"fluid deficiency—Qi stagnation—heat transformation",the entire pathological process of depression leading to T2DM can be categorized into three stages for diagnosis and treatment:"early stage—progressive stage—end stage".The attached test case was of hot Qi stagnation and fluid injury type depression,treated to relieve heat for notifying fluid,clearing Qi and relieving depression,administered with revised Lily Powder and achieved good curative effect.[Conclusion]In the early stage of depression leading to T2DM,the primary condition is fluid and blood deficiency,treated by nourishing fluids,with reference to the Baihe Dihuang Decoction.During the progressive stage,Qi stagnation predominates alongside fluid deficiency,treated by regulating Qi and resolving stagnation,with references to the Chaihu Baihe Decoction.In the end stage,characterized by internal heat,the treatment focuses on clearing heat and nourishing fluids,with representative formulas including Guolou Muli San and Baihe San,depending on the presence or absence of Qi stagnation.

[Objective]To explore the prevention and treatment of type-2 diabetes(T2DM)secondary to depression by using classical formulas,based on the theory of"thirst induced by depression"as described in the Huangdi Neijing,and systematically review relevant texts in traditional Chinese medicine literature.[Methods]Utilizing the"thirst induced by depression"theory from the Huangdi Neijing,this study employs literature research to analyze ancient texts such as Jingui Yaolue,Zhubing Yuanhou Lun and Shennong Bencao Jing for theoretical support regarding the causes,pathogenesis and transmission of depressive syndromes and consumption disorders.This foundation allows for an exploration of the mechanisms through which depressive syndromes lead to consumption and the therapeutic strategies for managing T2DM secondary to depression in clinical practice.Finally,a test case was attached to support it.[Results]The concept of"Yin syndrome"characterized by"weakened organ Qi"shares a common pathological basis with"consumption",particularly during the"weakened five organs"stage.The pathological progression is similar to that seen in the development of T2DM secondary to depression.Specifically,the"Yin syndrome"associated with"weakened organ Qi"may evolve into a consumption syndrome due to prolonged Qi stagnation and increasing heat.Therefore,based on the pathological sequence of"fluid deficiency—Qi stagnation—heat transformation",the entire pathological process of depression leading to T2DM can be categorized into three stages for diagnosis and treatment:"early stage—progressive stage—end stage".The attached test case was of hot Qi stagnation and fluid injury type depression,treated to relieve heat for notifying fluid,clearing Qi and relieving depression,administered with revised Lily Powder and achieved good curative effect.[Conclusion]In the early stage of depression leading to T2DM,the primary condition is fluid and blood deficiency,treated by nourishing fluids,with reference to the Baihe Dihuang Decoction.During the progressive stage,Qi stagnation predominates alongside fluid deficiency,treated by regulating Qi and resolving stagnation,with references to the Chaihu Baihe Decoction.In the end stage,characterized by internal heat,the treatment focuses on clearing heat and nourishing fluids,with representative formulas including Guolou Muli San and Baihe San,depending on the presence or absence of Qi stagnation.