1.Bibliographical cataloging for ancient TCM books
Hongtao LI ; Weina ZHANG ; Lin TONG ; Jingpeng DENG ; Qian ZHAO ; Honglei WANG ; Naiying LIU ; Mei SHI ; Qiang LIU ; Ying LIN ; Xiaohong ZHANG ; Lili FENG ; Mingrui ZHANG ; Yanqiu LUO ; Guangkun CHEN ; Yan DONG ; Bin LI ; Sihong LIU ; Bing LI ; Chen LI ; Meng LI ; Rui WANG ; He LU
International Journal of Traditional Chinese Medicine 2025;47(6):729-740
With reference to the Information and Documentation-Resource Description (GB/T 3792-2021) and Bibliographical Description for Ancient Chinese Books (GB/T 3792.7-2008) and other cataloging standards and rules, drawing on the practical experience of cataloging ancient TCM books, Bibliographical Cataloging for Ancient TCM Books was formulated. This standard specifies the entry items and their order of ancient TCM books, cataloging identifier, cataloging text, cataloging information source, and cataloging item details. The standard can provide standardized and unified guiding principles and methods for the work of ancient TCM books, and promote the sharing and utilization of ancient TCM books.
2.Comparison of therapeutic effects by testis sparing surgery and radical orchiectomy for benign testicular tumors
Taonong CAI ; Zhijun LIN ; Jiangli LU ; Mingrui LUO ; Haitao LIANG ; Zike QIN ; Yunlin YE
Journal of Modern Urology 2023;28(7):579-582
【Objective】 To explore the surgical treatments and therapeutic outcomes for benign testicular tumor. 【Methods】 Clinical data of 53 patients with benign testicular tumor treated with surgery during May 2004 and Jul.2021 were retrospectively analyzed. 【Results】 The postoperative pathological diagnosis of 53 patients included 33 patients with epidermal cysts, 12 with mature teratomas, 2 with bilateral testicular tumors (one of them was epidermal cysts in the left and mature teratoma in the right, and the other was bilateral leiomyomas), and 6 benign cases. Testis sparing surgery (TSS) group had 23 patients and radical orchiectomy (RO) group had 30 patients. There were no significant differences in patients’ age, tumor location, disease course, and ultrasound examination results between the two groups (P>0.05). The tumor size of the RO group was (2.60±0.94) cm, which was larger than that of the TSS group (1.55±0.52) cm (P<0.001). There were no statistically significant differences in surgical time and postoperative hospital stay between the two groups (P>0.05). A total of 15 patients (13 with TSS and 2 with RO) underwent intraoperative frozen rapid pathological examination (FSA), which was consistent with post-operative paraffin pathological results. Durign the follow up of 2-219 months,median 38 months, there was no recurrence in either groups. 【Conclusion】 Testis sparing surgery is a reliable treatment modality for benign testicular tumor, which may also decrease the level of androgen and incidence of asthenozoospermia. It can be considered for tumors less than 2 cm with benign tendency or uncertain nature.
3.Process in menstrual blood-derived mesenchymal stem cells for treatment of central nervous system diseases.
Mengmeng LIU ; Xinran CHENG ; Kaikai LI ; Mingrui XU ; Yongji WU ; Mengli WANG ; Qianru ZHANG ; Wenyong YAN ; Chang LUO ; Shanting ZHAO
Chinese Journal of Biotechnology 2018;34(5):644-652
Stem cell research has become a frontier in the field of life sciences, and provides an ideal model for exploring developmental biology problems such as embryogenesis, histiocytosis, and gene expression regulation, as well as opens up new doors for clinical tissue defective and inheritance diseases. Among them, menstrual blood-derived stem cells (MenSCs) are characterized by wide source, multi-directional differentiation potential, low immune rejection characteristics. Thus, MenSCs can achieve individual treatment and have the most advantage of the clinical application. The central nervous system, including brain and spinal cord, is susceptible to injury. And lethality and morbidity of them tops the list of all types of trauma. Compared to peripheral nervous system, recovery of central nervous system after damage remains extremely hard. However, the treatment of stem cells, especially MenSCs, is expected to solve this problem. Therefore, biological characteristics of MenSCs and their treatment in the respect of central nervous system diseases have been reviewed at home and abroad in recent years, so as to provide reference for the treatment of central nervous system diseases.
4.The effect of cognitive behavioral therapy on the functional connectivity of cognitive control network in patients with obsessive-compulsive disorder
Xiangyun YANG ; Zhanjiang LI ; Mingrui XIA ; Jia LUO ; Zhihua GUO ; Xiaojie YANG ; Jing LIU ; Shumin YAO ; Yun MA ; Pengchong WANG
Chinese Journal of Psychiatry 2018;51(5):309-315
Objective To investigate the regulatory effect of cognitive behavioral therapy (CBT) on the functional connectivity of cognitive control network in untreated obsessive-compulsive disorder (OCD) patients,so as to provide evidence for understanding the neurobiological mechanism of CBT.Methods A total of 45 OCD patients and 45 matched normal controls were recruited at the outpatient clinic in Beijing Anding Hospital.Four therapists provided 14 times of CBT treatment for OCD patients.All subjects underwent clinical symptom assessment and magnetic resonance imaging at baseline and at the end of 12 weeks.The clinical symptoms were assessed by the psychiatrists using Y-BOCS,HAMD17 and HAMA.The clinical symptoms of OCD patients before and after CBT treatment were compared.The GRETNA software package was used to preprocess the resting-state fMRI data.The whole brain function network was constructed with the template of Power 264 functional brain area as the network node.The function connection intensity outside the cognitive control network was calculated,and the function connection of 2 groups of brain networks at two timepoints were compared by repeated measurement of variance analysis.Results A total of 41 patients completed CBT.The scores of obsessive-compulsive symptoms,anxiety symptoms and depressive symptoms decreased at the end of 12th week,of which 32 patients were improved (Y-BOCS reduction ≥35%).Single factor repeated analysis of variance and post hoc tests were performed between patients with improvement and normal controls.At baseline,the functional connection between the cingulo-opercular network and the salience network of OCD patients was lower than that of the normal control (0.172±0.060 vs.0.215±0.076,t=1.731,P=0.040),it increased after treatment (0.186±0.171 vs.0.172±0.060,t=2.480,P=0.010).At baseline,the functional connection of cingulo-opercular network and subcortical network in OCD patients was lower than that of normal control (0.119±0.081 vs.0.129±0.070,t=1.640,P=0.040),and it increased after treatment (0.130±0.161 vs.0.119±0.081,t=2.421,P=0.020).At baseline,the functional connection between the frontal-parietal network and subcortical network was lower than that of normal controls (-0.004 ± 0.039 vs.0.021 ± 0.054,t=2.280,P=0.020),and it increased after treatment (0.020±0.042 vs.-0.004±0.039,t=-2.300 P=0.020).Conclusions CBT could effectively improve obsessive-compulsive symptoms accompanying with improvement of the external functional connectivity of cognitive control network in OCD patients.
5.The effect of cognitive behavioral therapy on the functional connectivity of cognitive control network in patients with obsessive-compulsive disorder
Xiangyun YANG ; Zhanjiang LI ; Mingrui XIA ; Jia LUO ; Zhihua GUO ; Xiaojie YANG ; Jing LIU ; Shumin YAO ; Yun MA ; Pengchong WANG
Chinese Journal of Psychiatry 2018;51(5):309-315
Objective To investigate the regulatory effect of cognitive behavioral therapy (CBT) on the functional connectivity of cognitive control network in untreated obsessive-compulsive disorder (OCD) patients,so as to provide evidence for understanding the neurobiological mechanism of CBT.Methods A total of 45 OCD patients and 45 matched normal controls were recruited at the outpatient clinic in Beijing Anding Hospital.Four therapists provided 14 times of CBT treatment for OCD patients.All subjects underwent clinical symptom assessment and magnetic resonance imaging at baseline and at the end of 12 weeks.The clinical symptoms were assessed by the psychiatrists using Y-BOCS,HAMD17 and HAMA.The clinical symptoms of OCD patients before and after CBT treatment were compared.The GRETNA software package was used to preprocess the resting-state fMRI data.The whole brain function network was constructed with the template of Power 264 functional brain area as the network node.The function connection intensity outside the cognitive control network was calculated,and the function connection of 2 groups of brain networks at two timepoints were compared by repeated measurement of variance analysis.Results A total of 41 patients completed CBT.The scores of obsessive-compulsive symptoms,anxiety symptoms and depressive symptoms decreased at the end of 12th week,of which 32 patients were improved (Y-BOCS reduction ≥35%).Single factor repeated analysis of variance and post hoc tests were performed between patients with improvement and normal controls.At baseline,the functional connection between the cingulo-opercular network and the salience network of OCD patients was lower than that of the normal control (0.172±0.060 vs.0.215±0.076,t=1.731,P=0.040),it increased after treatment (0.186±0.171 vs.0.172±0.060,t=2.480,P=0.010).At baseline,the functional connection of cingulo-opercular network and subcortical network in OCD patients was lower than that of normal control (0.119±0.081 vs.0.129±0.070,t=1.640,P=0.040),and it increased after treatment (0.130±0.161 vs.0.119±0.081,t=2.421,P=0.020).At baseline,the functional connection between the frontal-parietal network and subcortical network was lower than that of normal controls (-0.004 ± 0.039 vs.0.021 ± 0.054,t=2.280,P=0.020),and it increased after treatment (0.020±0.042 vs.-0.004±0.039,t=-2.300 P=0.020).Conclusions CBT could effectively improve obsessive-compulsive symptoms accompanying with improvement of the external functional connectivity of cognitive control network in OCD patients.
6.Correlation of monocyte counts prior to the collection of recombinant human granulocyte colony-stimulating factor primed bone marrow grafts with the quantities of CD34~+ cells in the grafts.
Yingjun CHANG ; Mingrui HUO ; Xiangyu ZHAO ; Xiaohua LUO ; Xiaojun HUANG
Chinese Journal of Practical Internal Medicine 2001;0(05):-
Objective To investigate the correlation of monocyte counts prior to the collection of recombinant human granulocyte colony-stimulating factor(rhG-CSF)primed bone marrow grafts(G-BM)with the quantities of CD34+ cells in the grafts.Methods From June 2004 to July 2007,fifty-three healthy donors were treated with rhG-CSF[5 ?g/(kg?d)]injected subcutaneously for five consecutive days.Bone marrow grafts and peripheral blood grafts were harvested on the 4th and 5th day,respectively.The quantities of CD34+ cells and blood routine prior to the collection of the G-BM were determined by flow cytometry and blood analyzer XL2100,respectively.Results The monocyte counts in peripheral blood(PB)of the 53 healthy donors were 896?424 per microliter.The counts of CD34+ cells per microliter and quantities of total CD34+ cells in the bone marrow grafts were 84?45 and(8.22?4.84)?107,respectively.Pearson correlation analysis indicated that the counts of monocyte in the PB correlated positively with the counts of CD34+ cells per microliter(r=0.573,P

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