Gamma Knife stereotactic radiosurgery is a highly precise radiotherapy technology,including the head Gamma Knife treatment system and the body Gamma Knife treatment system. Through multi-beam gamma rays focused on a specific target area,the lesion is exposed to high-dose radiation to cause radiation damage and necrosis,and the dose outside the target area is sharply reduced,thereby protecting the normal tissue outside the target area. Gamma Knife treatment has the advantages of being minimally invasive and effective treatment. Due to its precise and steep dose distribution,side effects are relatively few,and it can partially replace surgery or serve as a supplementary treatment after surgery. It was originally used for the treatment of craniocerebral diseases. In my country,Gamma Knife treatment was first applied to the treatment of body tumors. In recent years,with the widespread application of Gamma Knife radiosurgery technology,the incidence of adverse events associated with Gamma Knife radiotherapy has also increased. Gamma Knife adverse events mainly include those caused by treatment equipment failure and improper operation,as well as adverse events and complications resulting from tissue radiation damage. This article aims to comprehensively review and analyze the adverse events related to the use of Gamma Knife,and to explore the types,causes,preventive measures and coping strategies of these adverse events,in order to provide theoretical support and practical guidance for the safe use of Gamma Knife.

Gamma Knife stereotactic radiosurgery is a highly precise radiotherapy technology,including the head Gamma Knife treatment system and the body Gamma Knife treatment system. Through multi-beam gamma rays focused on a specific target area,the lesion is exposed to high-dose radiation to cause radiation damage and necrosis,and the dose outside the target area is sharply reduced,thereby protecting the normal tissue outside the target area. Gamma Knife treatment has the advantages of being minimally invasive and effective treatment. Due to its precise and steep dose distribution,side effects are relatively few,and it can partially replace surgery or serve as a supplementary treatment after surgery. It was originally used for the treatment of craniocerebral diseases. In my country,Gamma Knife treatment was first applied to the treatment of body tumors. In recent years,with the widespread application of Gamma Knife radiosurgery technology,the incidence of adverse events associated with Gamma Knife radiotherapy has also increased. Gamma Knife adverse events mainly include those caused by treatment equipment failure and improper operation,as well as adverse events and complications resulting from tissue radiation damage. This article aims to comprehensively review and analyze the adverse events related to the use of Gamma Knife,and to explore the types,causes,preventive measures and coping strategies of these adverse events,in order to provide theoretical support and practical guidance for the safe use of Gamma Knife.

OBJECTIVE:To provide reference for improving the rationality of perioperative prophylactic application of antibiotics in typeⅠincision operation of neurosurgery. METHODS:Medical records of 794 patients with typeⅠincision operation of neurosurgery were collected from our hospital during Jan.-Dec. 2016 in order to retrospectively investigate the perioperative prophylactic application of antibiotics and evaluate the rationality of drug use. RESULTS:Among all the 794 cases,433 used antibiotics for prophylaxis (single type was used in all cases),with utilization rate of 54.53％. Cefazolin(51.73％)and cefuroxime(21.48％)were the most frequently used antibiotics. The prophylactic application rate of 30 min-1 h before surgery was 85.45％ in 433 patients. Patients with prophylactic medication course≤24 h accounted for 68.36％. The main irrational drug use manifestations were long medication time(31.64％)and improper antibiotics selection(26.10％);other manifestations included improper medication timing(14.55％),etc. CONCLUSIONS:Unreasonable perioperative prophylactic application of antibiotics in typeⅠincision operation of neurosurgery exists in our hospital,such as improper drug selection,improper medication timing,long medication course. It is necessary to further strengthen the comprehensive interventions,so as to promote the rational use of antibiotics.

OBJECTIVE:To observe the effects of Compound biejia ruangan tablets combined Entecavir tablets on liver func-tion and hematoidin of patients with chronic hepatitis B(CHB)blood stasis syndrome. METHODS:Totally 110 patients with CHB blood stasis syndrome were selected from Neijiang Second People's Hospital,the Affiliated Hospital of Southwest Medical Univer-sity and Yibin First People's Hospital during Jan.-Dec. 2015. They were divided into control group and observation group by strati-fied blocked randomitation,with 55 cases in each group. Control group was given Entecavir tablets 0.5 mg,po,qd;observation group was additionally given Compound biejia ruangan tablets 2.0 g,po,tid. Both groups received treatment for 12 months. TCM syndrome scores,the levels of liver function indexes(AST,ALT,ALP,GGT),serum bilirubin(TBIL,DBIL,IBIL),liver fi-brosis indexes(LN,HA,PⅢP,Ⅳ-C)and Fibroscan(FS)were observed in 2 groups before and after treatment. The occurrence of ADR was recorded. RESULTS:In observation group,2 patients withdrew from the study,and 3 patients of control group with-drew from the study. Before treatment,there was no statistical significance in TCM syndrome scores,the levels of liver function in-dexes,serum bilirubin,liver fibrosis indexes and FS between 2 groups(P>0.05). After treatment,TCM syndrome scores,the lev-els of TBIL,IBIL,LN,HA,PⅢP,Ⅳ-C and FS in 2 groups were significantly decreased,while DBIL level was increased signifi-cantly,and the observation group was significantly better than control group,with statistical significance(P<0.05). The levels of AST and ALT in observation group were decreased significantly,while the levels of ALP and GGT were increased significantly, and the observation group was significantly better than control group,with statistical significance(P<0.05). There was no statisti-prove liver function indexes and bilirubin level,and inhibit liver fibrosis with good safety.

Objective: To develop novel targeted anticancer medicines for effective treatment of nasopharyngeal carcinoma ( NPC) , a prevalent malignant disease in southern China and southeast Asia.Methods: CNE cells were treated with a novel indolinone IF239 synthesized by our research group. Cell viability was determined by the acid phosphatase assay ( APA). Morphologic changes and adhesion status of CNE cells treated with IF239 were observed under a light microscope. Flow cytometry was used to analyze the cell cycle phases . Key regulating molecules in the cell cycle progression were detected by Western blotting. Results: IF239 had potent cytotoxic effect on CNE cells. The possible antitumor mechanisms of IF239 involved inhibition of cell adhesion and cell cycle arrest in the G2_/M phase. Moreover,G2_/M arrest caused by IF239 was related to up-regulation of both cyclin B1 and the phosphorylation level of CDK1. Conclusion: IF239 has high anticancer activity over CNE cells, and has unique anticancer mechanisms, suggesting that IF239 has promising application potentials.