Oral flora plays a vital role in human health and disease,and related studies have extended to the field of gastrointestinal diseases.Evidence has shown that microbial communities isolated from pancreatic tissue have a similar composition to oral flora,indicating a potential biological connection between them.Due to the advantages of noninvasiveness,simple operation,and low storage costs of collecting oral flora samples,it is feasible to obtain the information on oral flora and identify its characteristic changes.This approach not only helps to gain a deeper understanding of the pathogenesis of pancreatic diseases,but also lays a foundation for developing novel diagnostic tools and personalized treatment regimens.This article systematically reviews the research advances in the association between oral flora and pancreatic diseases,in order to provide new ideas for exploring the potential application value of oral flora in the early diagnosis,prognostic evaluation,and treatment of pancreatic diseases.

Oral flora plays a vital role in human health and disease,and related studies have extended to the field of gastrointestinal diseases.Evidence has shown that microbial communities isolated from pancreatic tissue have a similar composition to oral flora,indicating a potential biological connection between them.Due to the advantages of noninvasiveness,simple operation,and low storage costs of collecting oral flora samples,it is feasible to obtain the information on oral flora and identify its characteristic changes.This approach not only helps to gain a deeper understanding of the pathogenesis of pancreatic diseases,but also lays a foundation for developing novel diagnostic tools and personalized treatment regimens.This article systematically reviews the research advances in the association between oral flora and pancreatic diseases,in order to provide new ideas for exploring the potential application value of oral flora in the early diagnosis,prognostic evaluation,and treatment of pancreatic diseases.

Objective: To investigate the risk factors affecting the patency time of the125I seeds stent in malignant obstructive jaundice. Methods: A retrospective analysis of 113 patients with malignant obstructive jaundice underwent biliary tract125I seeds stent implantation. The gender, age, obstruction site, type of125I seeds stent, primary tumor type, and postoperative response to treatment of tumor were enrolled for analysis to evaluate the related risk factors affecting the patency time of the stent. Results: Univariate analysis showed that the location of biliary obstruction, the type of125I seeds stent, the type of primary tumor, and the type of primary tumor were the main factors affecting the patency time of the stent(P<0.001); Cox multivariate regression analysis showed biliary obstruction location, the type of125I seeds stent, and whether the primary tumor treated were independent factors that affected the patency time of the stent(P<0.001). Conclusion Multi-factor analysis shows that the location of biliary obstruction, the type of125I seeds stent, and the primary tumor are independent risk factors that affect the patency of the stent for malignant obstructive jaundice, which shows important markers for evaluating the prognosis of patients treated with this method.

Objective To investigate the angiographic manifestations of renal artery injury caused by percutaneous nephrolithotomy, and to evaluate the therapeutic effect of super-selective renal arterial embolization in treating renal artery injury. Methods A total of 22 patients with persistent or intermittent gross hematuria that occurred after percutaneous nephrolithotomy, who were encountered at authors’ hospital during the period from Jan. 2010 to June 2014, were included in this study. The diagnosis was confirmed by renal angiography in all patients, and super-selective renal arterial embolization with steel micro-coils was carried out in all patients. The patients were followed up for three months. The results were analyzed. Results Of the 22 patients, DSA examination showed that renal artery pseudoaneurysm (RAP) was found in 14 (63.6%), renal arteriovenous fistula (RAVF) in 5 (22.7%) and RAP associated with RAVF in 3 (13.6%). Renal angiography performed after super-selective renal arterial embolization showed that complete obstruction of the bleeding arteries was achieved in all patients, and the active bleeding stopped. Both the technical success rate and the hemostasis rate were 100%. During the follow-up period lasting for three months, no recurrence of hematuria or severe complications occurred. In 20 patients, different degree of embolism syndrome was observed after the treatment. Conclusion Renal artery pseudoaneurysm and renal arteriovenous fistula are the main types of renal artery injury after percutaneous nephrolithotomy. Super-selective renal arterial embolization with micro-coils can be used as the treatment of choice for patients who has failed to respond to conservative therapy.