Objective:To explore the exercise self-management cognition and real experience of elderly patients with colorectal cancer and sarcopenia, providing reference for the development of exercise intervention programs.Methods:This study was a descriptive qualitative research. From September to December 2023, purposive sampling was used to select 13 elderly patients with colorectal cancer and sarcopenia who visited Affiliated Hospital of Jiangnan University as participants, and face-to-face semi-structured in-depth interviews were conducted. Content analysis method was used to analyze, summarize, and extract themes from interview data.Results:Among the 13 elderly patients with colorectal cancer, there were six males and seven females aged 61 to 70 years. A total of three core themes and ten sub-themes were extracted, namely, cognition of disease and exercise (cognition of disease concepts, cognition of exercise self-management), diverse experiences of exercise self-management (positive support for exercise self-management, negative response to exercise self-management, and concerns about exercise self-management due to self-drag), and expectations for exercise self-management (information support and professional management needs, diversity needs of exercise content and methods, scientific needs of exercise volume and intensity, safety needs of exercise process, and systematic needs of system guarantees) .Conclusions:Elderly patients with colorectal cancer and sarcopenia have a certain level of enthusiasm and expectation for exercise self-management, but due to weak cognition of disease concepts and the benefits of exercise, self-drag, and insufficient system guarantees, there are negative responses to exercise. Medical and nursing staff need to strengthen their assessment of this population and develop scientific and systematic exercise intervention programs. The government and all sectors of society should actively guide people to have a positive cognition of diseases and provide certain policy guarantees.

Objective:To explore the exercise self-management cognition and real experience of elderly patients with colorectal cancer and sarcopenia, providing reference for the development of exercise intervention programs.Methods:This study was a descriptive qualitative research. From September to December 2023, purposive sampling was used to select 13 elderly patients with colorectal cancer and sarcopenia who visited Affiliated Hospital of Jiangnan University as participants, and face-to-face semi-structured in-depth interviews were conducted. Content analysis method was used to analyze, summarize, and extract themes from interview data.Results:Among the 13 elderly patients with colorectal cancer, there were six males and seven females aged 61 to 70 years. A total of three core themes and ten sub-themes were extracted, namely, cognition of disease and exercise (cognition of disease concepts, cognition of exercise self-management), diverse experiences of exercise self-management (positive support for exercise self-management, negative response to exercise self-management, and concerns about exercise self-management due to self-drag), and expectations for exercise self-management (information support and professional management needs, diversity needs of exercise content and methods, scientific needs of exercise volume and intensity, safety needs of exercise process, and systematic needs of system guarantees) .Conclusions:Elderly patients with colorectal cancer and sarcopenia have a certain level of enthusiasm and expectation for exercise self-management, but due to weak cognition of disease concepts and the benefits of exercise, self-drag, and insufficient system guarantees, there are negative responses to exercise. Medical and nursing staff need to strengthen their assessment of this population and develop scientific and systematic exercise intervention programs. The government and all sectors of society should actively guide people to have a positive cognition of diseases and provide certain policy guarantees.

Along with the increasing quantity of patients with end-stage liver diseases year by year, as an efficacious treatment, the safety and efficacy of liver transplantation are critical issues to be considered. In addition, liver transplant techniques have become a new research hot spot. In recent years, liver transplant techniques are constantly innovating and developing with the unremitting efforts of researchers. Researchers have successively developed multiple liver transplant techniques, such as split liver transplantation, ischemia-free liver transplantation, liver xenotransplantation, domino liver transplantation, delayed total hepatectomy combined with liver resection and segment Ⅱ-Ⅲ liver transplantation, heterotopic auxiliary liver transplantation on splenic fossa and magnetic anastomosis. It has laid a foundation for expanding the donor pool, improving clinical efficacy of liver transplantation and enhancing the quality of life of liver transplant recipients. In this article, the exploration, development, innovation and improvement of liver transplant techniques were reviewed and prospected, aiming to provide reference for clinical application of liver transplantation.

Peroxisome proliferator activated receptors (PPARs) are ligand activated nuclear transcription factors and one of the members of the non steroidal nuclear receptor superfamily.It can be divided into PPAR alpha,PPAR beta / delta and PPAR gamma three subtypes according to the different of its structure and function.Previous studies showed that PPARs participated in biochemical reactions and the regulation of other important biological activities such as lipogenesis,glucose metabolism,inflammation,insulin sensitivity and so on.Recent researches showed that PPARs also had effect of anti-fibrosis,protecting ischemia-reperfusion injury and inhibiting the growth and differentiation of tumor cells.This article reviewed the recent research progress of PPARs in these liver diseases.

Objective: To delineate the clinical and genetic features of two pedigrees affected with aromatic L-amino acid decarboxylase (AADC) deficiency. Methods: The clinical features, family history and results of genetic testing of 2 patients with AADC deficiency were retrospectively analyzed. Results: Both patients featured hypotension, developmental delay and oculogyric crisis during infancy.Genetic testing confirmed that they have respectively carried c. 714+ 4 (IVS6) A>T/c.175(exon2)G>A compound heterozygous variants and c. 714+ 4(IVS6)A>T homozygous variant. Conclusion The clinical manifestation of children with AADC deficiency may include hypotonia, developmental delay and paroxysmal oculogyric crisis. The combination of 3-O-methyldopa testing and variant analysis is not only very useful for early diagnosis, but also important for the evaluation of treatment effect and prognosis of the disease. Discovery of the novel variants has enriched the variant spectrum of AADC deficiency.

Bilioenterostomy with a wide variety of techniques is a common surgical operation in digestive surgery.Each of these surgeries has its own advantages and disadvantages.At present,Roux-en-Y choledochojejunostomy seems to be the dominant surgery,while other operations are used in some particular circumstances.Furthermore,some modified surgeries for bilioenterostomy have been conducted with the deepening understanding of the complications.Additionally,different kinds of new facilities and techniques have been applied to bilioenterostomy.Despite the controversy on specific issues,reasonable choice of bilioenterostomy should follow thc principles of specific purpose,correct choice and reliable effect.In other words,whether or not using bilioenterostomy should be considered correctly from the whole system,and then surgical methods should be accurately chose for patients,and finally avoiding the technical errors and guaranteeing the surgical effects.