Relevant literature published between January 1, 2010, and December 31, 2024, was retrieved from all sub-databases of the Web of Science Core Collection, including articles and reviews. CiteSpace 6.4.R1 was used to perform co-occurrence and burst analysis of journals, institutions, authors and keywords. VOSviewer 1.6.20 was applied to construct co-citation networks among countries/regions and references. SPSS 26.0 was utilized to analyze trends in publication volume and citation frequency.

A total of 113 080 publications on exercise interventions for overweight and obesity were obtained, including 98 188 articles and 14 892 reviews. Both annual publications (t=8.75, P < 0.01) and citation frequency (t=8.14, P < 0.01) showed significant growth trends. The United States contributed the highest number of publications (40 711) and citations (1 513 360). England contributed the highest Hirsch index (H-index)(246). Harvard University contributed the highest number of publications (8290), citations (503 061), the average citations per paper (60.68) and H-index (176). Moreno L A, from the University of Zaragoza in Spain, had the highest number of publications (160). High-frequency keywords primarily included "physical activity ""obesity ""overweight ""body mass index", and "exercise". Burst keywords mainly comprised "cardiometabolic risk ""eating habits", and "high-intensity interval training".

Over the past 15 years, the field of exercise intervention for overweight and obesity has received considerable academic attention. Key research hotspots focus on monitoring the incidence of overweight and obesity and the correlation between physical activity and the health outcomes of individuals with overweight and obesity. Future research directions emphasize the effect of high-intensity interval training on the cardiometabolic health of individuals with overweight and obesity, the interaction of dietary habits and physical activity, and the focus on enhance physical activity levels are the primary global trends in this research field.

This study is a retrospective analysis. Adult male patients with hemophilia A who visited the department of rehabilitation medicine at Peking Union Medical College Hospital from July 2022 to February 2024 were selected. Dual-energy X-ray absorptiometry (DXA) and high-resolution peripheral quantitative computed tomography (HR-pQCT) were used to assess the bone mineral density (BMD) of the patients. Anterolateral X-rays and Pettersson radiology scores were performed on the left ankle joint. Hemophilia Joint Health Score (HJHS) version 2.1 was used to calculate the HJHS score of the left ankle and evaluate the joint health status of the included patients. Serum bone metabolism indexes including total procollagen Ⅰ N-terminal propeptide (TP1NP) and C-terminal crosslinking β-isomerized carboxy-telopeptide of type Ⅰ collagen (β-CTX), and serum 25-(OH)D₃ were detected. The patients' body composition parameters were measured, including the body mass index(BMI)and the skeletal muscle mass index (SMI). The correlation analysis of BMD detection values and its possible influencing factors was carried out.

A total of 33 adult male patients with hemophilia A were selected, including 22 severe patients and 11 moderate patients, with an average age of 31.1±8.4 years. The hip BMD of the included patients was lower than the predicted value of age to varying degrees, and the minimum Z-value was -3.0. The Pettersson score of the left ankle was 7.75±0.94 and the HJHS score was 8.88±1.25. Elevated β-CTX occurred in 33.3% of patients. Serum 25-(OH)D₃ deficiency was found in 33.3% of patients. 45.5% of patients had insufficient 25-(OH)D₃. 21.2% of patients were obese and 42.4% were overweight. SMI values in 21.2% of patients met the diagnostic criteria for sarcopenia. There was a negative correlation between femoral neck and Wards triangle BMD and the HJHS score of left ankle (r=-0.814, P=0.014; r=-0.733, P=0.039). In addition, β-CTX was positively correlated with TP1NP (r=0.845, P=0.004).

The hip BMD of adult hemophilia patients decreased.Joint dysfunction may be one of the factors associated with reduced bone density in patients with hemophilia. The increase in osteoclast activity may be accompanied by an increase in compensatory osteoblast activity.