Colorectal cancer (CRC) is one of the most common malignant tumors recorded worldwide. This condition has high morbidity and mortality and seriously endangers people's health. Traditional diagnostic models fail to meet people's current needs for real-time monitoring of tumors. Compared with traditional detection methods, ctDNA detection is not only noninvasive but can also attain real-time detection of comprehensive genomic information of tumors. The advancement of detection technology has gradually highlighted the potential of ctDNA detection in the clinical treatment of CRC. This article reviews the advancements on the clinical application of ctDNA in early screening, minimal residual disease detection, and guidance on individualized treatment of CRC patients.

Colorectal cancer is a highly malignant disease characterized by a poor prognosis. Although the targeted therapy based on chemotherapy improves the efficacy, the prognosis of advanced colorectal cancer patients is poor. Poly (ADP-ribose) polymerase (PARP) inhibitors, which act through a synergistic lethal mechanism, have been widely utilized in treating ovarian and breast cancer cases with homologous recombination deficiency and have demonstrated positive clinical outcomes. Recently, due to advancements in next-generation sequencing technology and the development of precision targeted therapy, an increasing number of clinical trials have started to investigate the potential of PARP inhibitors in colorectal cancer treatment. This review summarized the molecular mechanism of PARP inhibitors in the treatment of colorectal cancer and the application of several combined PARP inhibitors therapy regimens in colorectal cancer, in order to provide new insights for the treatment of colorectal cancer.

By carrying out hazard vulnerability analysis,the main emergencies that hospitals need to deal with are identi-fied,and various emergency plans are formulated and improved in a targeted manner,so as to improve the emergency response capacity of hospitals.In this paper,Kaiser model risk matrix was used to evaluate and rank the relative risk of risk events in a tertiary hospital in Tianjin.It was found that the relative risk degree of risk events faced by the sample hospital was lower than that of similar studies,but it was still necessary to pay attention to five key risk events,including violent medical disputes,haze,wind,snow and ice,and earthquake.The purpose is to provide theoretical basis for the continuous improvement of hospital emer-gency system,and is the preliminary basis for hospitals to do a good job in emergency management and improve emergency han-dling ability.

By carrying out hazard vulnerability analysis,the main emergencies that hospitals need to deal with are identi-fied,and various emergency plans are formulated and improved in a targeted manner,so as to improve the emergency response capacity of hospitals.In this paper,Kaiser model risk matrix was used to evaluate and rank the relative risk of risk events in a tertiary hospital in Tianjin.It was found that the relative risk degree of risk events faced by the sample hospital was lower than that of similar studies,but it was still necessary to pay attention to five key risk events,including violent medical disputes,haze,wind,snow and ice,and earthquake.The purpose is to provide theoretical basis for the continuous improvement of hospital emer-gency system,and is the preliminary basis for hospitals to do a good job in emergency management and improve emergency han-dling ability.