Objective:To investigate the value of abnormal protein (TAP) and C-reactive protein (CRP) levels in the prediction of human papillomavirus (HPV) infection and cervical lesions in patients with peripheral blood tumors.Methods:A total of 216 patients with cervical lesions who received treatment in Shan County Central Hospital from June 2019 to May 2021 were included in this cross-sectional study. According to HPV results, these patients were divided into a high-risk HPV infection group ( n = 122), a low-risk HPV infection group ( n = 76), and an HIV-uninfected group ( n = 18). TAP and CRP levels in peripheral blood were determined in each group and analyzed. Results:TAP and CRP levels in the high-risk HPV infection group were (243.29 ± 19.43) μm 2 and (37.49 ± 10.50) mg/L, respectively, and they were (125.46 ± 10.37) μm 2 and (26.27 ± 7.28) mg/L in the low-risk HPV infection group, and (74.51 ± 9.29) μm 2 and (74.51 ± 9.29) mg/L in the HIV-uninfected group. There were significant differences in TAP and CRP levels among the three groups ( F = 12.40, 6.34, both P < 0.001). TAP and CRP levels in the low-risk HPV infection group were significantly higher than those in the HIV-uninfected group ( t = 4.02, 3.26, both P < 0.05). TAP and CRP levels in the peripheral blood of patients with chronic cervicitis were (63.25 ± 5.80) μm 2 and (13.37 ± 5.29) mg/L, which were significantly different from those in patients with cervical intraepithelial neoplasia or cervical cancer ( F = 21.35, 8.26, both P < 0.05). TAP and CRP levels in the peripheral blood of patients with cervical intraepithelial neoplasia grade II and cervical intraepithelial neoplasia grade III were significantly higher than those in patients with cervical intraepithelial neoplasia grade I (both P < 0.05). TAP and CRP levels in the peripheral blood of patients with cervical cancer were significantly higher than those in patients with various grades of cervical intraepithelial neoplasia (all P < 0.05). The Pearson correlation analysis results showed that the load of high-risk human papillomavirus deoxyribonucleic acid (HPV-DNA) was positively correlated with blood TAP and CRP levels ( r = 0.64, 0.24, both P < 0.001). The area under the curve regarding the combined detection of TAP and CRP levels was 0.927 (95% CI: 0.873-0.967), with sensitivity and specificity of 91.0% and 93.6%, respectively. Conclusion:TAP and CRP levels in peripheral blood can reflect HPV infection and cervical lesion and are closely related to the type of HPV infection and the degree of cervical lesion. Combined detection of the two can improve the diagnostic efficiency of cervical cancer and deserves clinical promotion.