Objective To investigate the effects of different dialysis modalities on serum levels of dephosphorylated-uncarboxylated matrix Gla protein(dp-ucMGP),lipid profiles,and vascular calcification in maintenance hemodialysis(MHD)patients,and to identify the risk factors associated with vascular calcification in this population.Methods A total of 87 MHD patients admitted to the hospital between January 2019 and December 2022 were enrolled as study participants.Based on their dialysis modalities,they were categorized into three groups:the hemodialysis(HD)group,the HD combined with hemodiafiltration(HD+HDF)group,and the HD,HDF combined with hemoperfusion(HD+HDF+HP)group,with 29 patients in each group.The serum dp-ucMGP levels,lipid profiles,and extent of vascular calcification were compared across the three groups.Patients were divided into a vascular calcification group and a non-vascular calcification group based on the presence or absence of vascular calcification.Univariate analyses and multivariate analysis were performed to identify factors potentially associated with vascular calcification in patients undergoing MHD.Results The results demonstrated that the levels of blood phosphorus,intact parathyroid hormone(iPTH),serum dp-ucMGP,total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)were significantly higher in the HD group compared to the HD+HDF and HD+HDF+HP groups.Conversely,high-density lipoprotein cholesterol(HDL-C)levels were significantly lower in the HD group than in the other two groups,and all differences were statistically signifi-cant(P<0.05).The levels of blood phosphorus,iPTH,and serum dp-ucMGP in the HD+HDF group were sig-nificantly higher than those in the HD+HDF+HP group,with statistically significant differences(P<0.05).Compared with the HD group,the vascular calcification rate in the HD+HDF+HP group was significantly lower(P<0.05).In comparison to the non-vascular calcification group,the vascular calcification group exhibited signifi-cant increases in MHD dialysis duration,age,pulse pressure,blood phosphorus,blood calcium,iPTH,LDL-C,TC,and dp-ucMGP(P<0.05).Binary logistic regression analysis revealed that dialysis vintage,age,serum phos-phorus,calcium,iPTH,and serum dp-ucMGP levels were independently associated with a higher risk of vascular calcification in MHD patients(P<0.05).Conclusions Compared with the simple HD or HD+HDF dialysis mo-dalities,the HD+HDF+HP regimen is associated with lower levels of serum phosphorus,iPTH,dp-ucMGP,lipids,and vascular calcification prevalence in MHD patients.However,dialysis modality itself was not an indepen-dent predictor of vascular calcification.Instead,factors such as dialysis vintage,age,serum phosphorus,calcium,iPTH,and dp-ucMGP were independently associated with vascular calcification in this population.

Objective To investigate the effects of different dialysis modalities on serum levels of dephosphorylated-uncarboxylated matrix Gla protein(dp-ucMGP),lipid profiles,and vascular calcification in maintenance hemodialysis(MHD)patients,and to identify the risk factors associated with vascular calcification in this population.Methods A total of 87 MHD patients admitted to the hospital between January 2019 and December 2022 were enrolled as study participants.Based on their dialysis modalities,they were categorized into three groups:the hemodialysis(HD)group,the HD combined with hemodiafiltration(HD+HDF)group,and the HD,HDF combined with hemoperfusion(HD+HDF+HP)group,with 29 patients in each group.The serum dp-ucMGP levels,lipid profiles,and extent of vascular calcification were compared across the three groups.Patients were divided into a vascular calcification group and a non-vascular calcification group based on the presence or absence of vascular calcification.Univariate analyses and multivariate analysis were performed to identify factors potentially associated with vascular calcification in patients undergoing MHD.Results The results demonstrated that the levels of blood phosphorus,intact parathyroid hormone(iPTH),serum dp-ucMGP,total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)were significantly higher in the HD group compared to the HD+HDF and HD+HDF+HP groups.Conversely,high-density lipoprotein cholesterol(HDL-C)levels were significantly lower in the HD group than in the other two groups,and all differences were statistically signifi-cant(P<0.05).The levels of blood phosphorus,iPTH,and serum dp-ucMGP in the HD+HDF group were sig-nificantly higher than those in the HD+HDF+HP group,with statistically significant differences(P<0.05).Compared with the HD group,the vascular calcification rate in the HD+HDF+HP group was significantly lower(P<0.05).In comparison to the non-vascular calcification group,the vascular calcification group exhibited signifi-cant increases in MHD dialysis duration,age,pulse pressure,blood phosphorus,blood calcium,iPTH,LDL-C,TC,and dp-ucMGP(P<0.05).Binary logistic regression analysis revealed that dialysis vintage,age,serum phos-phorus,calcium,iPTH,and serum dp-ucMGP levels were independently associated with a higher risk of vascular calcification in MHD patients(P<0.05).Conclusions Compared with the simple HD or HD+HDF dialysis mo-dalities,the HD+HDF+HP regimen is associated with lower levels of serum phosphorus,iPTH,dp-ucMGP,lipids,and vascular calcification prevalence in MHD patients.However,dialysis modality itself was not an indepen-dent predictor of vascular calcification.Instead,factors such as dialysis vintage,age,serum phosphorus,calcium,iPTH,and dp-ucMGP were independently associated with vascular calcification in this population.

Objective:To investigate the high flux hemodialysis (HFD) on the application effect of severe renal failure patients the level of inflammatory factors, blood lipid and protein. Methods:In 2012 January to 2013 December was performed in 80 patients with severe renal failure in the treatment of MHD, were randomly divided into two groups, study group 40 cases by high-throughput MHD treatment, 40 cases in the control group using conventional MHD treatment. Results: There was no significant difference in two groups before treatment of various inflammatory factors difference (P>0.05); after the treatment, two groups of patients with TNF- α, IL-6 and hs-CRP levels were significantly lower(t=14.138, t=5.891, t=11.093;P<0.01), and lower levels of TNF-α, IL-6 and hs-CRP levels than the control group after treatment, the study group, with statistical significance correlation between data comparison of difference (t=17.913, P<0.05). Comparison of the plasma protein levels had no significant difference between the two groups before treatment (P>0.05);after the treatment, patients in study group were TP, ALB andβ2-M compared with those before treatment were significantly improved, ALB of control group had obvious improvement than before treatment (P<0.05); improve study group for plasma proteins relevant indexes are the control group was significant (t=2.515, t=59.923, t=3.474, P<0.01). No significant differences between the level of each lipid index (P>0.05);after the treatment, patients in study group TC and TG compared with those before treatment were significantly improved after treatment, and compared with the control group index improved significantly (t=2.963, t=6.914; P<0.01). Conclusion:High throughput MHD therapy based on conventional MHD filtration of small molecular toxin traits on patients with severe renal failure, increase the filtration range, clear promote inflammatory molecules, plasma proteins, blood lipid molecules, such as in large molecules, so as to achieve a better therapeutic effect.