OpenSim is an open source, free motion simulation and gait analysis software, which can be used to dynamically simulate and analyze the complex motion of the human body, and is widely used in human biomechanical research. Since OpenSim can analyze multi-dimensional motion data such as muscle strength, joint torque, and muscle synergistic activation during human movement, it can be used to study the biomechanical mechanism of musculoskeletal imbalance diseases and various treatment methods in TCM orthopedics, and has a broad application prospect in the field of TCM orthopedics. By the analysis of the basic characteristics, elements, analysis process, and application prospects of OpenSim, it is concluded that OpenSim musculoskeletal model has a large application space in the field of traditional Chinese medicine orthopedic, which is helpful to explain the pathogenesis and mechanism of diseases, and promote the precision diagnosis and treatment of orthopedics diseases;the application of OpenSim musculoskeletal model can solve the problem that the previous research paid attention to the bone malalignment and not enough attention to the tendon, and provide a new method for the research of orthopedic diseases. At present, there are still problems in the promotion and application of OpenSim, such as large equipment requirements and high operation threshold. Therefore, multidisciplinary cooperation, clinical research, and data sharing are the basic research strategies in this field.
Humans ; Biomechanical Phenomena ; Orthopedics ; Traumatology ; Software ; Medicine, Chinese Traditional ; Musculoskeletal System ; Models, Biological

OBJECTIVE: To examine the mechanistic of organochlorine-associated changes in lung function. METHODS: This study investigated 76 healthy older adults in Jinan, Shandong Province, over a five-month period. Personal exposure to organochlorines was quantified using wearable passive samplers, while inflammatory factors and thyroid hormones were analyzed from blood samples. Participants' lung function was evaluated. After stratifying participants according to their thyroid hormone levels, we analyzed the differential effects of organochlorine exposure on lung function and inflammatory factors across the low and high thyroid hormone groups. Mediation analysis was further conducted to elucidate the relationships among organochlorine exposures, inflammatory factors, and lung function. RESULTS: Bis (2-chloro-1-methylethyl) ether (BCIE), was negatively associated with forced vital capacity (FVC, -2.05%, 95% CI: -3.11% to -0.97%), and associated with changes in inflammatory factors such as interleukin (IL)-2, IL-7, IL-8, and IL-13 in the low thyroid hormone group. The mediation analysis indicated a mediating effect of IL-2 (15.63%, 95% CI: 0.91% to 44.64%) and IL-13 (13.94%, 95% CI: 0.52% to 41.07%) in the association between BCIE exposure and FVC. CONCLUSION Lung function and inflammatory factors exhibited an increased sensitivity to organochlorine exposure at lower thyroid hormone levels, with inflammatory factors potentially mediating the adverse effects of organochlorines on lung function.
Environmental Exposure ; Hydrocarbons, Chlorinated/metabolism* ; China ; Ethyl Ethers/metabolism* ; Environmental Monitoring ; Thyroid Hormones/blood* ; Lung/physiology* ; Inhalation Exposure/statistics & numerical data* ; Air Pollution/statistics & numerical data* ; Air Pollutants/metabolism* ; Humans ; Male ; Female ; Middle Aged ; Aged

Objectives:To investigate the effect of lower-level three-column osteotomies(L-3COs)on the restoration of coronal and sagittal balance in adult spinal deformity(ASD).Methods:The clinical data of ASD patients treated with L-3COs(L4,L5 level)in our hospital between January 2012 and May 2022 were retrospectively analyzed.A total of 34 patients were included in this study,including 7 males and 27 females,aged 51.4±16.2 years(range 18-72 years).According to the Qiu classification,10 cases were classifies as type A,13 cases as type B,and 11 cases as type C;9 cases were of congenital spinal deformity,3 cases were of idiopathic scoliosis,20 cases were of degenerative scoliosis,and 2 cases were of neurogenic scoliosis;7 patients underwent subsequent revision.All the patients underwent L-3COs+pelvic fixation and were followed up for ≥2 years.Imaging parameters assessing coronal and sagittal spine and trunk balance were measured at preoperation,immediate postoperatively,and at the final follow-up to evaluate the corrective outcomes.Coronal parameters included the Cobb angle,coronal balance distance(CBD),and L4 tilt angle.Sagittal parameters included sacral slope(SS),pelvic tilt(PT),pelvic incidence(PI),lumbar lordosis(LL),L4-Sl lordosis,thoracic kyphosis(TK),and sagittal vertical axis(SVA).The operative time,intraoperative blood loss,osteotomy level,and complications were documented,and clinical outcomes were appraised using the Scoliosis Research Society-22(SRS-22)questionnaire.Results:The operative time was 5.7±0.9h(4.6-7.0h),and the intraoperative blood loss was 1870±550mL(1320-3840mL).The osteotomy level was L4 in 25 cases and L5 in 9 cases.Except for PI,all the coronal and sagittal parameters significantly improved postoperatively compared to preoperative values(P＜0.05).The CBD of the patients was 24.52±19.60mm preoperatively and was corrected to 11.94±10.74mm immediately postoperatively(P=0.032).The SVA was 98.25±48.40mm preoperatively and reconstructed to 31.26±36.06mm immediately postoperatively(P＜0.001).The LL was 8.59°±11.76° preoperatively and was significantly corrected to 36.82°±10.73° immediately postoperatively(P＜0.001).8 patients suffered with postoperative mechanical complication,no revision for complications,and there were 2 cases of proximal junctional kyphosis(PJK),5 instances of rod or screw breakage,1 case of screw loosening or pullout,and 1 case of coronal imbalance(1 case presented with both PJK and coronal imbalance).The scores of all dimensions of SRS-22 questionaire(function,pain,self-image,mental health,total score)at final follow-up were significantly higher than those preoperatively(P＜0.001).Conclusions:L-3COs demonstrate significant correction effects for ASD patients with severe coronal and sagittal imbalance and loss of LL,which successfully alleviates pain and enhances long-term quality of life,with a relatively low incidence of postoperative mechanical complications,making it an effective orthopaedic technique.

p120-catenin(p120ctn)is one of the crucial members of armadillo family,which is well known as a core stabilizing factor for vascular endothelial cadherin(VE-cadherin).Throughout the entire process of vascular development,p120ctn plays multiple roles.From neovascularization to endothelial barrier,the presence of p120ctn is indispensable.It participates in regulating the normal development of vertebrate embryo vasculature and promoting endothelial cell proliferation.Additionally,p120ctn contributes to the maintenance and remodeling of adherens junctions and can modulate adhesion strength by altering cell morphology.This review summarized the latest research progress on p120ctn from neovascular development and endothelial barrier function.

Objectives:To investigate the effect of lower-level three-column osteotomies(L-3COs)on the restoration of coronal and sagittal balance in adult spinal deformity(ASD).Methods:The clinical data of ASD patients treated with L-3COs(L4,L5 level)in our hospital between January 2012 and May 2022 were retrospectively analyzed.A total of 34 patients were included in this study,including 7 males and 27 females,aged 51.4±16.2 years(range 18-72 years).According to the Qiu classification,10 cases were classifies as type A,13 cases as type B,and 11 cases as type C;9 cases were of congenital spinal deformity,3 cases were of idiopathic scoliosis,20 cases were of degenerative scoliosis,and 2 cases were of neurogenic scoliosis;7 patients underwent subsequent revision.All the patients underwent L-3COs+pelvic fixation and were followed up for ≥2 years.Imaging parameters assessing coronal and sagittal spine and trunk balance were measured at preoperation,immediate postoperatively,and at the final follow-up to evaluate the corrective outcomes.Coronal parameters included the Cobb angle,coronal balance distance(CBD),and L4 tilt angle.Sagittal parameters included sacral slope(SS),pelvic tilt(PT),pelvic incidence(PI),lumbar lordosis(LL),L4-Sl lordosis,thoracic kyphosis(TK),and sagittal vertical axis(SVA).The operative time,intraoperative blood loss,osteotomy level,and complications were documented,and clinical outcomes were appraised using the Scoliosis Research Society-22(SRS-22)questionnaire.Results:The operative time was 5.7±0.9h(4.6-7.0h),and the intraoperative blood loss was 1870±550mL(1320-3840mL).The osteotomy level was L4 in 25 cases and L5 in 9 cases.Except for PI,all the coronal and sagittal parameters significantly improved postoperatively compared to preoperative values(P＜0.05).The CBD of the patients was 24.52±19.60mm preoperatively and was corrected to 11.94±10.74mm immediately postoperatively(P=0.032).The SVA was 98.25±48.40mm preoperatively and reconstructed to 31.26±36.06mm immediately postoperatively(P＜0.001).The LL was 8.59°±11.76° preoperatively and was significantly corrected to 36.82°±10.73° immediately postoperatively(P＜0.001).8 patients suffered with postoperative mechanical complication,no revision for complications,and there were 2 cases of proximal junctional kyphosis(PJK),5 instances of rod or screw breakage,1 case of screw loosening or pullout,and 1 case of coronal imbalance(1 case presented with both PJK and coronal imbalance).The scores of all dimensions of SRS-22 questionaire(function,pain,self-image,mental health,total score)at final follow-up were significantly higher than those preoperatively(P＜0.001).Conclusions:L-3COs demonstrate significant correction effects for ASD patients with severe coronal and sagittal imbalance and loss of LL,which successfully alleviates pain and enhances long-term quality of life,with a relatively low incidence of postoperative mechanical complications,making it an effective orthopaedic technique.

p120-catenin(p120ctn)is one of the crucial members of armadillo family,which is well known as a core stabilizing factor for vascular endothelial cadherin(VE-cadherin).Throughout the entire process of vascular development,p120ctn plays multiple roles.From neovascularization to endothelial barrier,the presence of p120ctn is indispensable.It participates in regulating the normal development of vertebrate embryo vasculature and promoting endothelial cell proliferation.Additionally,p120ctn contributes to the maintenance and remodeling of adherens junctions and can modulate adhesion strength by altering cell morphology.This review summarized the latest research progress on p120ctn from neovascular development and endothelial barrier function.

Objective To investigate the infection status and changing trend of hepatitis C virus(HCV)infection in hospitalized patients in medical institutions,and provide reference for formulating HCV infection prevention and control strategies.Methods HCV infection surveillance results from cross-sectional survey data reported to China Healthcare-associated Infection(HAI)Surveillance System in 2020 were summarized and analyzed,HCV positive was serum anti-HCV positive or HCV RNA positive,survey result was compared with the survey results from 2003.Results In 2020,1 071 368 inpatients in 1 573 hospitals were surveyed,738 535 of whom underwent HCV test,4 014 patients were infected with HCV,with a detection rate of 68.93％and a HCV positive rate of 0.54％.The positive rate of HCV in male and female patients were 0.60％and 0.48％,respectively,with a statistically sig-nificant difference(x2=47.18,P＜0.001).The HCV positive rate in the 50-＜60 age group was the highest(0.76％),followed by the 40-＜50 age group(0.71％).Difference among all age groups was statistically signifi-cant(x2=696.74,P＜0.001).In 2003,91 113 inpatients were surveyed.35 145 of whom underwent HCV test,resulting in a detection rate of 38.57％;775 patients were infected with HCV,with a positive rate of 2.21％.In 2020,HCV positive rates in hospitals of different scales were 0.46％-0.63％,with the highest in hospital with bed numbers ranging 600-899.Patients'HCV positive rates in hospitals of different scales was statistically signifi-cant(X2=35.34,P＜0.001).In 2020,12 provinces/municipalities had over 10 000 patients underwent HCV-rela-ted test,and HCV positive rates ranged 0.19％-0.81％,with the highest rate from Hainan Province.HCV posi-tive rates in different departments were 0.06％-0.82％,with the lowest positive rate in the department of pedia-trics and the highest in the department of internal medicine.In 2003 and 2020,HCV positive rates in the depart-ment of infectious diseases were the highest,being 7.95％and 3.48％,respectively.Followed by departments of orthopedics(7.72％),gastroenterology(3.77％),nephrology(3.57％)and general intensive care unit(ICU,3.10％)in 2003,as well as departments of gastroenterology(1.35％),nephrology(1.18％),endocrinology(0.91％),and general intensive care unit(ICU,0.79％)in 2020.Conclusion Compared with 2003,HCV positive rate decreased significantly in 2020.HCV infected patients were mainly from the department of infectious diseases,followed by departments of gastroenterology,nephrology and general ICU.HCV infection positive rate varies with gender,age,and region.

Objective To observe the efficacy and safety of Morinda officinalis oligosaccharides in the continuation treatment of mild and moderate depression.Methods An open,single-arm,multi-center design was adopted in our study.Adult patients with mild and moderate depression who had received acute treatment of Morinda officinalis oligosaccharides were enrolled and continue to receive Morinda officinalis oligosaccharides capsules for 24 weeks,the dose remained unchanged during continuation treatment.The remission rate,recurrence rate,recurrence time,and the change from baseline to endpoint of Hamilton Depression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Clinical Global Impression-Severity(CGI-S)and Arizona Sexual Experience Scale(ASEX)were evaluated.The incidence of treatment-related adverse events was reported.Results The scores of HAMD-17 at baseline and after treatment were 6.60±1.87 and 5.85±4.18,scores of HAMA were 6.36±3.02 and 4.93±3.09,scores of CGI-S were 1.49±0.56 and 1.29±0.81,scores of ASEX were 15.92±4.72 and 15.57±5.26,with significant difference(P＜0.05).After continuation treatment,the remission rate was 54.59％(202 cases/370 cases),and the recurrence rate was 6.49％(24 cases/370 cases),the recurrence time was(64.67±42.47)days.The incidence of treatment-related adverse events was 15.35％(64 cases/417 cases).Conclusion Morinda officinalis oligosaccharides capsules can be effectively used for the continuation treatment of mild and moderate depression,and are well tolerated and safe.

The patient,a male newborn,was admitted to the hospital 2 hours after birth due to prematurity(gestational age 27+5 weeks)and respiratory distress occurring 2 hours postnatally.After admission,the infant developed fever and elevated C-reactive protein levels.On the fourth day after birth,metagenomic next-generation sequencing of cerebrospinal fluid indicated a positive result for Mycoplasma hominis(9 898 reads).On the eighth day,a retest of cerebrospinal fluid metagenomics confirmed Mycoplasma hominis(56 806 reads).The diagnosis of purulent meningitis caused by Mycoplasma hominis was established,and the antibiotic treatment was switched to moxifloxacin[5 mg/(kg·day)]administered intravenously for a total of 4 weeks.After treatment,the patient's cerebrospinal fluid tests returned to normal,and he was discharged as cured on the 76th day after birth.This article focuses on the diagnosis and treatment of neonatal Mycoplasma hominis purulent meningitis,introducing the multidisciplinary diagnosis and treatment of the condition in extremely preterm infants.[Chinese Journal of Contemporary Pediatrics,2024,26(4):432-436]

Patients with severe trauma require an extremely timely treatment and transfusion plays an irreplaceable role in the emergency treatment of such patients. An increasing number of evidence-based medicinal evidences and clinical practices suggest that patients with severe traumatic bleeding benefit from early transfusion of low-titer group O whole blood or hemostatic resuscitation with red blood cells, plasma and platelet of a balanced ratio. However, the current domestic mode of blood supply cannot fully meet the requirements of timely and effective blood transfusion for emergency treatment of patients with severe trauma in clinical practice. In order to solve the key problems in blood supply and blood transfusion strategies for emergency treatment of severe trauma, Branch of Clinical Transfusion Medicine of Chinese Medical Association, Group for Trauma Emergency Care and Multiple Injuries of Trauma Branch of Chinese Medical Association, Young Scholar Group of Disaster Medicine Branch of Chinese Medical Association organized domestic experts of blood transfusion medicine and trauma treatment to jointly formulate Chinese expert consensus on blood support mode and blood transfusion strategies for emergency treatment of severe trauma patients ( version 2024). Based on the evidence-based medical evidence and Delphi method of expert consultation and voting, 10 recommendations were put forward from two aspects of blood support mode and transfusion strategies, aiming to provide a reference for transfusion resuscitation in the emergency treatment of severe trauma and further improve the success rate of treatment of patients with severe trauma.