Objective To analyze the prognostic value of carotid ultrasound quantitative parameters combined with serum TNF-α and receptor-interacting protein kinase 1(RIPK1)levels for patients with acute ischemic stroke(AIS).Methods A total of 110 AIS patients admitted in our hospital from February 2020 to May 2024 were enrolled,and according to their modified Rankin scale(mRS)score after 3 months,they were divided into a good prognosis group(76 cases)and a poor prognosis group(34 cases).The carotid ultrasound quantitative parameters such as intima-media thickness(CIMT),end diastolic velocity(EDV)and peak systolic velocity(PSV)and serum TNF-α and RIPK1 levels were detected.The relationship of the parameters and the serum levels with prognosis was analyzed.Results The poor prognosis group had significantly higher carotid CIMT and EDV values and serum levels of TNF-α and RIPK1,and lower PSV value than the good prognosis group(P＜0.01).The CIMT,PSV,EDV,TNF-α and RIPK1 were independent in-fluencing factors of prognosis of AIS patients(P＜0.01).ROC curve analysis showed that the AUC value of CIMT,PSV,EDV,TNF-α and RIPK1 combined together in predicting the poor prognosis of AIS patients was 0.979,with a sensitivity of 94.10％and a specificity of 75.00％.Conclusion Carotid ultrasound quantitative parameters combined with serum TNF-α and RIPK1 levels can effectively assess the prognosis of AIS patients,with high predictive value.

Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves a wide range of content, along with high requirements for doctor′s professionalism and multi-specialty teamwork, as well as a great demand for time-sensitive treatments. However, this is not matched with critical care professionals and the current state of medical care in China. Telemedicine, which shortens the distance of medical professionals and the gap of disease diagnosis and treatments in various regions through electronic information, can effectively solve the current problem. Therefore, there is an urgent need to develop a standardized, high-quality visualization telemedicine round system .Therefore, experts have been organized to search domestic and foreign literature on telemedicine round for critically ill patients and to form this consensus based on clinical experiences so as to further improve the level of critical care treatments in regions.

Objective To analyze the prognostic value of carotid ultrasound quantitative parameters combined with serum TNF-α and receptor-interacting protein kinase 1(RIPK1)levels for patients with acute ischemic stroke(AIS).Methods A total of 110 AIS patients admitted in our hospital from February 2020 to May 2024 were enrolled,and according to their modified Rankin scale(mRS)score after 3 months,they were divided into a good prognosis group(76 cases)and a poor prognosis group(34 cases).The carotid ultrasound quantitative parameters such as intima-media thickness(CIMT),end diastolic velocity(EDV)and peak systolic velocity(PSV)and serum TNF-α and RIPK1 levels were detected.The relationship of the parameters and the serum levels with prognosis was analyzed.Results The poor prognosis group had significantly higher carotid CIMT and EDV values and serum levels of TNF-α and RIPK1,and lower PSV value than the good prognosis group(P＜0.01).The CIMT,PSV,EDV,TNF-α and RIPK1 were independent in-fluencing factors of prognosis of AIS patients(P＜0.01).ROC curve analysis showed that the AUC value of CIMT,PSV,EDV,TNF-α and RIPK1 combined together in predicting the poor prognosis of AIS patients was 0.979,with a sensitivity of 94.10％and a specificity of 75.00％.Conclusion Carotid ultrasound quantitative parameters combined with serum TNF-α and RIPK1 levels can effectively assess the prognosis of AIS patients,with high predictive value.

Turning to critical illness is a common stage of various diseases and injuries before death. Patients usually have complex health conditions, while the treatment process involves a wide range of content, along with high requirements for doctor′s professionalism and multi-specialty teamwork, as well as a great demand for time-sensitive treatments. However, this is not matched with critical care professionals and the current state of medical care in China. Telemedicine, which shortens the distance of medical professionals and the gap of disease diagnosis and treatments in various regions through electronic information, can effectively solve the current problem. Therefore, there is an urgent need to develop a standardized, high-quality visualization telemedicine round system .Therefore, experts have been organized to search domestic and foreign literature on telemedicine round for critically ill patients and to form this consensus based on clinical experiences so as to further improve the level of critical care treatments in regions.

Objective To compare the diagnostic efficacy of 68Ga-PSMA-617 PET/CT and multiparameter MRI in the diagnosis of primary tumors of newly diagnosed prostate cancer.and analyze the correlation between SUVmax and clinical parameters of prostate cancer.Methods A retrospective analysis of the clinical data of 104 patients with newly diagnosed prostate cancer who underwent 68Ga-PSMA-617 PET/CT and multi-parametric MRI from June 2017 to April 2018.The final pathological results were used as the gold standard for diagnosis.The age ranged from 42 to 89 years,with an average of (70.4 ± 8.9) years.The median total serum PSA was 18.44 (8.71,48.01)ng/ml.The pathological results were positive in 68 cases and negative in 36 cases.The sensitivity,specificity was calculated,the ROC curve was drawn and AUC value was calculated.The relationship between SUVmax value of prostate cancer and clinical parameters was analyzed.Results The sensitivity of 68Ga-PSMA-617 PET/CT was 95.59％ (65/68) and the specificity was 88.89％ (32/36);the sensitivity of MRI examination was 91.18％ (62/68) and the specificity was 63.89％ (23/36).There were statistical differences between the specificity of the two examination (P =0.012).The ROC curve of 68 Ga-PSMA-617 PET/CT was plotted and the AUC value was 0.954.Among the 104 suspected prostate cancer patients,the median SUVmax of benign prostatic tissue was 3.20(2.83,3.70),and the median SUVmax of prostate cancer tissue was 12.21 (7.48,17.46).Among 68 patients with prostate cancer,there were statistical differences between SUVmax values of prostate cancer tissues with different Gleason scores (P ＜ 0.01),ISUP group (P ＜ 0.01),risk grades (P =0.021),and SUVmax values.There was a positive correlation with Gleason score and ISUP group (r1 =0.7420,P＜0.01;r2 =0.754,P＜0.01).Conclusions The 68Ga-PSMA-617 PET/CT examination had higher diagnostic efficacy than the multiparametric MRI for prostate cancer.The higher the SUVmax value predict the higher grade and higher risk.