Dysphagia is a common non-motor symptom of Parkinson's disease (PD). The pathogenesis of the disease includes central changes and peripheral changes. The mechanism of acupuncture intervention is mainly to protect DA neurons and central acetylcholinergic neurons, and the research on the peripheral mechanism of action is currently lacking. Acupuncture, electro-acupuncture, warm acupuncture, and combined acupuncture therapy have showed satisfactory clinical curative effects. Among them, Lianquan (CV 23),Fengchi (GB 20), Yamen (GV 15) and Yifeng (TE 17) are commonly used in routine acupuncture. The acupoints with high frequency of bloodletting are Jinjin (EX-HN 12) and Yuye (EX-HN 13). However, the existing studies have the problems such as small sample size, inconsistent operation plans, and effect evaluation standards difference, which need to be further improved.

Objective To determine the incidence and risk factors of acute kidney injury (AKI) in respiratory failure patients.Method Clinical data of 235 patients diagnosed as respiratory failure admitted in respiratory division and internal medicine intensive care unit in Renji Hospital from January 2006 to December 2008 were analyzed retrospectively.Patients'demographics,clinical data and laboratory examinations before and after respiratory failure were collected.The incidence,clinical risk factors and hospital mortality of AKI in the respiratory failure patients were analyzed.Multivariate Logistic regression analysis was used to investigate the independent risk factors of AKI in these patients.Results Of the total 235 patients,the average age was (70.05±12.85) years old,the ratio of male to female was 1.90:1.Seventy-seven patients developed AKI and the incidence was 32.8％.The incidence of AKI in those with hypertension (44.4％ vs 26.6％,P＜0.01) or chronic kidney disease(66.7％ vs 31.3％,P＜0.01) was significantly higher.The incidence of AKI in patients with mechanical ventilation was much higher than those without mechanical ventilation(44.8％ vs 13.3％,P＜0.01).The incidence of multi-organ system failure (33.8％ vs 5.7％,P＜0.01),the failure of weaning from mechanical ventilation(69.2％vs 32.5％,P＜0.01) and the mortality (51.9％ vs 13.3％,P＜0.01) in AK1 patients were higher than those without AKI.Multivariate Logistic regression analysis showed that age (OR=1.668),anemia (OR=0.980),baseline serum creatinine (OR=1.071) and mechanical ventilation (OR=3.222) were independent risk factors of AKI.Conclusions Incidence and mortality of AKI are quite high in respiratory failure patients.Age,baseline serum creatinine,anemia and mechanical ventilation are independent risk factors of AKI.