The comorbidity of obsessive-compulsive disorder and other severe mental illnesses is common in clinical practice, which indicates a possible common genetic basis of them. Studies on this common genetic basis can be helpful for directing the clinical treatment strategy and further understanding the etiology and pathogenesis of obsessive-compulsive disorder and its comorbidity of other severe mental illnesses. This study summarized the updated research about the shared genetic basis between obsessive-compulsive disorder and other severe mental illnesses, to provide a possible direction for the exploration of pathogenesis and mechanism of the diseases and the formulation of treatment strategies.

The comorbidity of obsessive-compulsive disorder and other severe mental illnesses is common in clinical practice, which indicates a possible common genetic basis of them. Studies on this common genetic basis can be helpful for directing the clinical treatment strategy and further understanding the etiology and pathogenesis of obsessive-compulsive disorder and its comorbidity of other severe mental illnesses. This study summarized the updated research about the shared genetic basis between obsessive-compulsive disorder and other severe mental illnesses, to provide a possible direction for the exploration of pathogenesis and mechanism of the diseases and the formulation of treatment strategies.