PURPOSE: This study was conducted to examine the effects of individual counseling for bus-drivers on cerebrovascular and cardiovascular disease prevention. METHODS: The one-group pretest-posttest design was used. This study presents a secondary analysis of data collected in 'contents of cerebrovascular and cardiovascular disease prevention program for bus-drivers in one workplace in Seoul, Korea. The data were collected from 56 bus drivers, using questionnaires from September 10th to November 20th, 2014. The analysis was conducted with chi2 test and paired samples t-test using SPSS/Win 21.0. RESULTS: After the intervention, the participants showed a significant decrease in the level of systolic blood pressure (p=.003) and a significant increase in the total cholesterol level (p=.030). The distribution of cardiovascular risk groups changed after the intervention: 5.3% decreased in the high risk group, 16.1% decreased in the medium risk group, and 3.5% decreased in the low risk group, while 25.0% increased in the normal group. CONCLUSION: The comprehensive individual counseling including simple screening, tailored education and counseling is effective to manage their lifestyle risk factors, resulting in better maintenance of their health as well as preventing cerebrovascular and cardiovascular disease.
Blood Pressure ; Cardiovascular Diseases* ; Cholesterol ; Counseling* ; Education ; Korea ; Life Style ; Mass Screening ; Risk Factors ; Seoul ; Statistics as Topic*

Choroidal metastasis from colorectal cancer is very rare and has not been reported before in Korea. We report a case of eye hyperemia and discomfort in a patient with advanced colon cancer. Orbit magnetic resonance imaging and positron emission tomography revealed an enhancing mass within the temporal side of the left orbit, suggestive of choroidal metastasis from the colorectal adenocarcinoma. The condition's rarity may be due to the long and distant pathway from the colon to the orbit. The presentation usually suggests extensive hematogeneous cancer dissemination and a poor prognosis. However, palliative radiotherapy may be an effective treatment for choroidal metastasis.
Adenocarcinoma ; Choroid* ; Colon* ; Colonic Neoplasms* ; Colorectal Neoplasms ; Humans ; Hyperemia ; Korea ; Magnetic Resonance Imaging ; Neoplasm Metastasis* ; Orbit ; Positron-Emission Tomography ; Prognosis ; Radiotherapy*

PURPOSE: This study was conducted to understand the subjective symptom rate of musculoskeletal disease of male taxi drivers and comprehend general features, health behavior features, and factors related to the subjective symptoms of musculoskeletal system depending on the level of job stress. METHODS: The participants were 206 male taxi drivers from 4 transportation companies in the Seoul and Gyeonggi areas. The investigation was conducted from July 20th 2012 to August 20th 2012 through a self-administered questionnaire survey. RESULTS: The participants who exercised less than three times per week complained about the subjective symptoms of the musculoskeletal system (p=.016) 13.770 times as more as than those of the participants who exercised more than three times per week the participants who had a higher level of job stress complained about the subjective symptoms of the muscular skeletal (p=.011) 1.051times as more as than those who had a relatively lower level of job stress. CONCLUSION: This study recommends that it is necessary to provide exercise programs and arrange various plans reducing job stress to prevent muscular skeletal disease and minimize the disease susceptibility of taxi drivers.
Disease Susceptibility ; Gyeonggi-do ; Health Behavior ; Humans ; Male ; Musculoskeletal Diseases ; Musculoskeletal System ; Surveys and Questionnaires ; Seoul ; Transportation

PURPOSE: This study was conducted to understand the subjective symptom rate of musculoskeletal disease of male taxi drivers and comprehend general features, health behavior features, and factors related to the subjective symptoms of musculoskeletal system depending on the level of job stress. METHODS: The participants were 206 male taxi drivers from 4 transportation companies in the Seoul and Gyeonggi areas. The investigation was conducted from July 20th 2012 to August 20th 2012 through a self-administered questionnaire survey. RESULTS: The participants who exercised less than three times per week complained about the subjective symptoms of the musculoskeletal system (p=.016) 13.770 times as more as than those of the participants who exercised more than three times per week the participants who had a higher level of job stress complained about the subjective symptoms of the muscular skeletal (p=.011) 1.051times as more as than those who had a relatively lower level of job stress. CONCLUSION: This study recommends that it is necessary to provide exercise programs and arrange various plans reducing job stress to prevent muscular skeletal disease and minimize the disease susceptibility of taxi drivers.
Disease Susceptibility ; Gyeonggi-do ; Health Behavior ; Humans ; Male ; Musculoskeletal Diseases ; Musculoskeletal System ; Surveys and Questionnaires ; Seoul ; Transportation

No abstract available.

Reactive oxygen species (ROS) contribute to the development of a number of neuronal diseases including ischemia. DJ-1, also known to PARK7, plays an important role in transcriptional regulation, acting as molecular chaperone and antioxidant. In the present study, we investigated whether DJ-1 protein shows a protective effect against oxidative stress-induced neuronal cell death in vitro and in ischemic animal models in vivo. To explore DJ-1 protein's potential role in protecting against ischemic cell death, we constructed cell permeable Tat-DJ-1 fusion proteins. Tat-DJ-1 protein efficiently transduced into neuronal cells in a dose- and time-dependent manner. Transduced Tat-DJ-1 protein increased cell survival against hydrogen peroxide (H2O2) toxicity and also reduced intracellular ROS. In addition, Tat-DJ-1 protein inhibited DNA fragmentation induced by H2O2. Furthermore, in animal models, immunohistochemical analysis revealed that Tat-DJ-1 protein prevented neuronal cell death induced by transient forebrain ischemia in the CA1 region of the hippocampus. These results demonstrate that transduced Tat-DJ-1 protein protects against cell death in vitro and in vivo, suggesting that the transduction of Tat-DJ-1 may be useful as a therapeutic agent for ischemic injuries related to oxidative stress.
Animals ; Blood-Brain Barrier/metabolism ; Brain Ischemia/*metabolism/pathology/prevention & control ; CA1 Region, Hippocampal/drug effects/metabolism/pathology ; Cell Line, Tumor ; Cell Survival/drug effects ; Gerbillinae ; Intracellular Signaling Peptides and Proteins/*administration & dosage/biosynthesis/pharmacokinetics ; Lipid Peroxidation ; Malondialdehyde/metabolism ; Mice ; Neuroprotective Agents/*administration & dosage/pharmacokinetics ; Oncogene Proteins/*administration & dosage/biosynthesis/pharmacokinetics ; *Oxidative Stress ; Prosencephalon/drug effects/metabolism/pathology ; Rats ; Recombinant Fusion Proteins/*administration & dosage/biosynthesis/pharmacokinetics ; tat Gene Products, Human Immunodeficiency Virus/*administration & dosage/biosynthesis/pharmacokinetics

BACKGOUND/AIMS: Pancreatitis is the most common and important complication of an endoscopic retrograde cholangiopancreatography (ERCP). The aim of this study was to identify risk factors for post ERCP-pancreatitis in patients pretreated with nafamostat mesilate, a synthetic protease inhibitor. METHODS: A total of 247 patients who underwent an ERCP were evaluated prospectively. Potential risk factors of post-ERCP pancreatitis in patients pretreated with nafamostat mesilate were evaluated. RESULTS: Twenty-four patients (9.7%) and nine patients (3.6%) developed post-ERCP hyperamylasemia and pancreatitis, respectively. As determined by univariate analysis among the potential risk factors, we found a procedure time over 20 minutes, pancreatic duct cannulation over four times, prior post-ERCP pancreatitis and the absence of a common bile duct (CBD) stone as risk factors for post-ERCP hyperamylasemia. We also found a patient age under 60 years, a procedure time over 20 minutes, pancreatic duct cannulation over four times and the absence of a CBD stone as risk factors for post-ERCP pancreatitis (p<0.05). As determined by multivariate analysis, pancreatic cannulation over four times is independently associated with post-ERCP hyperamylasemia (p=0.038; OR, 5.165; 95% CI, 1.093~24.412) and post-ERCP pancreatitis (p=0.002; OR, 33.122; 95% CI, 3.526~311.138). CONCLUSIONS: A repeated pancreatic duct cannulation is the most important risk factor for post-ERCP pancreatitis in patients pretreated with nafamostat mesilate.
Catheterization ; Cholangiopancreatography, Endoscopic Retrograde ; Common Bile Duct ; Guanidines ; Humans ; Hyperamylasemia ; Mesylates ; Multivariate Analysis ; Pancreatic Ducts ; Pancreatitis ; Prospective Studies ; Protease Inhibitors ; Risk Factors

Russell body gastritis is a very rare disease with an uncertain cause. The disease is often misdiagnosed as xanthoma, signet ring cell carcinoma, MALT lymphoma and plasmacytoma. Russell body gastritis is characterized by the polyclonic nature of immunoglobulin and usually tests positive to the kappa and lambda light chains. It is different from a Mott cell tumor, which shows monoclonal nature of immunoglobulin. Until now, few cases have been reported and most were associated with a Helicobacter pylori infection. We encountered a case of Russell body gastritis associated with a Helicobacter pylori infection, which showed complete improvement after eradicating the Helicobacter pylori infection. We report this case with review of the relevant literature.
Carcinoma, Signet Ring Cell ; Gastritis* ; Helicobacter pylori* ; Helicobacter* ; Immunoglobulins ; Lymphoma, B-Cell, Marginal Zone ; Plasmacytoma ; Rare Diseases ; Xanthomatosis

Mercury is one of the heavy metals that cause intoxications. Mercury can cause muscular tremor, psychic irritability, renal toxicity and so on. Mercury intoxications usually occur chrough chronic respiratory ingestion. We describe a case in that a woman had applicated inorganic mercury to her whole body and developed mercury intoxications which can be characterized by the whole body skin rash, fever, acute renal failure and the hepatotoxicity appeared. We managed the patient with diuretics, antibiotics and continuous veno-venous hemodiafiltration. On the 6th hospital day, serum creatinine was normalized. Since then, the skin rash and hepatotoxicity were gradually alleviated.
Acute Kidney Injury* ; Anti-Bacterial Agents ; Creatinine ; Diuretics ; Eating ; Exanthema ; Female ; Fever ; Hemodiafiltration ; Humans ; Metals, Heavy ; Skin* ; Tremor

Extraskeletal Ewing's sarcoma (EES) is a rare soft tissue tumor morphologically indistinguishable from the more common Ewing's sarcoma of bone. We report a case of EES arising in the hard palate of 34-yr-old male patient. Microscopically, the monotonous small round cells without neuronal differentiation showed membranous positive immunoreactivity for MIC2/CD99 and vimentin. Ultrastructurally, the tumor cells showed a few intracytoplasmic organelles without evidence of neurosecretory granules or neurofilaments. The EWS-FLI1 chimeric gene was identified using the nested reverse transcriptase-polymerase chain reaction.
Adult ; Antigens, CD/analysis ; Cell Adhesion Molecules/analysis ; Humans ; Immunohistochemistry ; Male ; Oncogene Proteins, Fusion/genetics ; Palatal Neoplasms/genetics/metabolism/*pathology ; Palate, Hard/metabolism/*pathology ; Proto-Oncogene Protein c-fli-1/genetics ; Reverse Transcriptase Polymerase Chain Reaction ; Sarcoma, Ewing's/genetics/metabolism/*pathology ; Transcription, Genetic ; Vimentin/analysis