1.Interoceptive Dysfunction in Psychiatric Disorders and Non-invasive Neuromodulation for Improving Interoception.
Huiru CUI ; Jijun WANG ; Chunbo LI
Neuroscience Bulletin 2025;41(8):1487-1499
Dysfunction of the interoceptive system is recognized as an important component of clinical symptoms, including anxiety, depression, psychosis, and other mental disorders. Non-invasive neuromodulation is an emerging clinical intervention approach, and over the past decade, research on non-invasive neuromodulation aimed at regulating interoception has rapidly developed. This review first outlines the pathways of interoceptive signals and assessment methods, then summarizes the interoceptive abnormalities in psychiatric disorders and current studies for non-invasive neuromodulation targeting interoception, including intervention modes, target sites, interoceptive measures, and potential neurobiological mechanisms. Finally, we discuss significant research challenges and future directions.
Humans
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Interoception/physiology*
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Mental Disorders/therapy*
2.Analysis on Care Service Preferences of Community Patients With Severe Mental Disorders in Beijing Based on Discrete Choice Experiment.
Jin-Qi ZHU ; Wei LU ; Yu XIN ; Yun CHEN ; Qing-Zhi HUANG ; Jun-Li ZHU
Acta Academiae Medicinae Sinicae 2025;47(3):425-433
Objective To gain insights into the care service preferences and willingness of patients with severe mental disorders in Beijing,analyze the main factors affecting their participation in care services,and provide data support and decision-making reference for the optimal design of care services for patients with severe mental disorders and the improvement of relevant policies.Methods In July 2022,a questionnaire survey was conducted for a part of Beijing community patients with severe mental disorders selected by multi-stage stratified sampling,including the basic personal information and the preferences of discrete choice experiment.A mixed Logit model was used to perform regression analysis on the care service preferences,and the trade off between general and monetary attributes was quantified by willingness to pay(WTP).Results A total of 242 questionnaires were distributed,and 181 valid questionnaires were collected,with a response rate of 74.79%.The regression coefficients for the four attributes-service type,service content,service frequency,and service cost-all showed statistical significance(all P<0.05).Patients' most preferred attribute level was a service frequency covering about 90% of the time per month/year( β=1.059),while the least preferred was full-time residential care( β=-1.025).Increasing the service frequency from 30% to 90% corresponded to a WTP of 492.5 yuan,while changing the service type from home-based care to full-time residential care resulted in a WTP of -476.6 yuan.Moreover,there were differences in care service preferences and WTP among patient groups with different characteristics(all P<0.05).Conclusions Service type,service content,service frequency,and service cost all significantly affect the care service preferences of patients with severe mental disorders.There is heterogeneity in care service preferences among patient groups with different characteristics.
Humans
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Mental Disorders/therapy*
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Patient Preference
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Beijing
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Surveys and Questionnaires
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Male
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Female
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Choice Behavior
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Adult
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Middle Aged
3.Clinical significance and intervention strategy of gastrointestinal psychiatry.
Qi Yi CHEN ; Ju Bao LU ; Huan Long QIN ; Ning LI
Chinese Journal of Gastrointestinal Surgery 2022;25(9):771-776
With the development of global economy and society,the number of patients who suffer from functional gastrointestinal disorders (FGID) and mental illness is growing. In recent years, a substantial amount of high-quality research evidence shows that these two kinds of diseases often coexist, and they are mutually causal, and their common pathophysiology is the abnormal interaction of "bacteria-gut-brain axis". In clinical practice, there are some problems, such as insufficient recognition and attention of both doctors and patients to its clinical manifestations, lack of understanding of pathophysiological mechanism, and lack of overall and integrated views of intervention methods, which may be the main factors of poor curative effect at present. Therefore, according to the global research progress and the author's clinical experience, we put forward a new viewpoint of "gastrointestinal psychiatry", it concluded that clinical intervention strategies needed to include dietary and lifestyle changes as well as multidisciplinary interventions such as probiotics, prebiotic, fecal microbiota transplantation and cognitive psychology. On the basis of gastrointestinal psychiatry, this paper systematically elaborated the diagnosis and treatment of this kind of diseases.
Gastrointestinal Diseases/drug therapy*
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Humans
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Mental Disorders/therapy*
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Prebiotics
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Probiotics
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Psychiatry
4.Employers' attitudes towards employing people with mental health conditions.
Yunjue ZHANG ; Jue Hua LAU ; Fiona DEVI ; Janhavi Ajit VAINGANKAR ; Shazana SHAHWAN ; Pratika SATGHARE ; Wen Lin TEH ; Roystonn KUMAR ; Chong Min Janrius GOH ; Yogeswary MANIAM ; Swapna VERMA ; Siow Ann CHONG ; Mythily SUBRAMANIAM
Annals of the Academy of Medicine, Singapore 2022;51(9):578-579
5.YU Tian-yuan's experience in the clinical application of Danzhong (CV 17) for mental illness.
Hou-Rong WANG ; Zhi-Feng LIU ; Tian-Yuan YU ; Ying-Qi ZHANG ; Yi JIAO ; Di LIU ; Qian GUAN ; Ya-Jing XU
Chinese Acupuncture & Moxibustion 2022;42(5):552-554
To summarize YU Tian-yuan's experience of applying Danzhong (CV 17) for mental illness in acupuncture and tuina. YU Tian-yuan uses Danzhong (CV 17) alone or in combination with other acupoints to treat mental illnesses such as insomnia, palpitation and chest distress. Professor YU emphasizes 4 tips when treating diseases, nourishing the heart to tranquilize by light stimulation; regulating spirit by combined stimulation; leaving the acupoints and holding on the meridian for a wide range of stimulation; using rubbing and pushing manipulation in several directions for regulating qi to soothe the chest. And in clinical practice, formed a unique therapy to treat mental illness.
Acupuncture
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Acupuncture Points
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Acupuncture Therapy
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Humans
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Mental Disorders/therapy*
;
Meridians
6.Professor
Wen FU ; Meng-Yu WANG ; Bai-le NING ; Peng ZHOU ; Wen-Bin FU
Chinese Acupuncture & Moxibustion 2021;41(10):1140-1144
The paper summarizes the ideas and characteristics of acupoint selection in treatment of mental disorder with acupuncture and moxibustion by professor
Acupuncture Points
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Acupuncture Therapy
;
Humans
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Mental Disorders/therapy*
;
Meridians
;
Moxibustion
7.Study advance of depressive animal models and its application in traditional Chinese medicines.
Xue-Xue WANG ; Zhu-Ping TAO ; Ying LI ; Can-Wei LI ; Meng-Ran FAN ; Wei-Hong LIU ; Gui-Ning WEI ; Peng-Fei GAO
China Journal of Chinese Materia Medica 2020;45(11):2473-2480
Depression is a kind of mental disease with main symptoms of low mood and lack of pleasure, which seriously endangers human health. An appropriate depressive animal model is of great significance for the study of depression and new antidepressant drugs, while the suitable selection and matching of experimental animals, modeling methods and evaluation indexes are critical to eva-luate the scientificity and effectiveness of the depressive animal model. The study advance of depressive animal models in the aspects of experimental animal selection, modeling principle and method, characteristics, evaluation indexes and their application in traditional Chinese medicine are summarized through the systematic review of relevant literatures in PubMed, CNKI and other databases. The depressive animal modeling methods utilized in recent studies include stress, glucocorticoid induction, reserpine induction, lipopolysaccharide induction, surgical modeling, gene knockout, joint application modeling methods. Stress method is better to simulate the depressive symptoms of clinical patients, whereas there are some deficiencies, such as long modeling time and large cost. The depressive animal models induced by glucocorticoid, reserpine and lipopolysaccharide have the advantages of short modeling time and good controllability, but with a poor reliability. The pathogenesis of surgical modeling is highly matched with that of clinical depressive patients, whereas it has the defect of long postoperative recovery period. Gene knockout models can be used to study the precise role of specific genes in depression. However, its applicability may be restricted in studies on depression. The joint application modeling method can improve its reliability and accuracy, and attracts more and more attention. This paper provides a reference for the selection of animal models in future studies of pathological mechanism of depression, and screening and evaluation of antidepressant drugs.
Animals
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Antidepressive Agents
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therapeutic use
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Depression
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Disease Models, Animal
;
Humans
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Medicine, Chinese Traditional
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Mental Disorders
;
drug therapy
;
Reproducibility of Results
8.National expert consensus on psychological rehabilitation of burn children (2020 version).
Chinese Journal of Burns 2020;36(11):987-992
The incidence of psychological stress and disorder in children after burns is high, and the mental health status highly affects the lifesaving, wound repair, and functional and psychological rehabilitation of the children. At present, the psychological disorder of burn children has not attracted enough attention and the relevant rehabilitation treatment measures also need to be standardized urgently. The Burn and Trauma Branch of Chinese Geriatrics Society organized the related national experts to provide recommendations for the diagnosis and treatment of psychological disorders in burn children, and the consensus is formulated. This article introduced the manifestations, common assessment scales, and key points of psychological rehabilitation therapies at different stages for the psychological stress and disorder of burn children. Effective interventions and treatments include psychological interventions, behavioral therapy, cognitive therapy, cognitive behavioral therapy, play therapy, music therapy, and medication. Peer support and summer camps for burn children are also beneficial for their psychological rehabilitation and re-entering to society. In the psychological intervention and treatment for the children, the mental development level of children in different ages must be taken into consideration, and the close participation and cooperation of the parents are needed. In addition, the parents of burn children often suffer from stress response and psychological disorders. Recommended treatments for the parents are also provided in this consensus.
Burns/therapy*
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Child
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Consensus
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Humans
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Mental Disorders/therapy*
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Parents
;
Wound Healing
9.Effects of Acceptance Commitment Therapy Based Recovery Enhancement Program on Psychological Flexibility, Recovery Attitude, and Quality of Life for Inpatients with Mental Illness
Journal of Korean Academy of Psychiatric and Mental Health Nursing 2019;28(1):79-90
PURPOSE: The purpose of this study was to (1) develop an acceptance commitment therapy (ACT) based recovery enhancement program for inpatients with mental illness and (2) test the effects of the program on patients' psychological flexibility, recovery attitude, and quality of life. METHODS: A mixed methods design was used: a combination of a repeated-measure design with a non-equivalent control group and qualitative data collection. The participants were 41 inpatients with mental illness (experimental group: 20, control group: 21). The ACT based recovery enhancement program was conducted over four sessions for a total of two weeks. Data were collected from December 2018 to January 2019. RESULTS: Study results revealed that the ACT based recovery enhancement program was effective for psychological flexibility (F=150.71, p<.001), recovery attitude (F=60.22, p<.001), and quality of life (F=31.59, p<.001) for inpatients with mental illness. CONCLUSION: The results of this study suggest that the ACT based recovery enhancement program can be used as an effective mental health nursing intervention for psychological flexibility, recovery attitude, and quality of life of inpatients with mental illness.
Acceptance and Commitment Therapy
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Data Collection
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Hospitalization
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Humans
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Inpatients
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Mental Disorders
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Pliability
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Psychiatric Nursing
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Quality of Life
10.Fangji Dihuang Decoction formula syndrome and Fengyin Decoction formula syndrome:application in stroke and mental disorders.
China Journal of Chinese Materia Medica 2019;44(3):602-607
Fangji Dihuang Decoction and Fengyin Decoction, which were firstly recorded in Synopsis of the Golden Chamber, could be used to treat stroke. However, both of these two decoctions are used infrequently. There is a clear pathogenesis of modern pathophysiology behind Fangji Dihuang Decoction syndrome and Fengyin Decoction syndrome, which can be interpreted by modern language of science. Fangji Dihuang Decoction can nourish Yin, tonify kidney, extinguish the wind, and dredge collaterals. It could be used to treat mania caused by cerebral infarction, senile dementia, Alzheimer's disease and other cerebrovascular diseases, and opened up the precedent of nourishing Yin and expelling wind to treat stroke in later generations. Fengyin Decoction can clear heat, extinguish the wind, and calm the mind. It can be used to treat cerebral infarction, limb paralysis and epileptic seizures with heat syndrome. It may be equivalent to "oriental olanzapine", and opened up the precedent of smoothing liver and suppressing Yang to treat stroke in later generations. They can be used in the combination, with a high application value in treating stroke and mental diseases.
Cerebral Infarction
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drug therapy
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Drugs, Chinese Herbal
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therapeutic use
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Humans
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Medicine, Chinese Traditional
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Mental Disorders
;
drug therapy
;
Stroke
;
drug therapy

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