Cancer is a highly deadly disease, with breast cancer, cervical cancer, endometrial cancer, and ovarian cancer being the most prevalent in women. However, traditional cancer treatments present challenges due to their strong toxic side effects and adverse reactions. Numerous studies have demonstrated that natural products derived from various plants possess therapeutic and preventive properties against cancer. These phytochemicals have been extensively investigated as a potential alternative to conventional chemotherapy drugs, owing to their safety and efficacy. This article provides a comprehensive review of the recent advances in the chemoprevention and mechanisms of phytochemicals against the four major female cancers. The focus will be on how these phytochemicals regulate cancer cell proliferation, apoptosis, invasion, and metastasis to impede cancer progression. Given their extensive clinical applications, phytochemicals hold great promise in the field of cancer treatment. It hopes that this review will inspire more researchers to explore the potential of these natural compounds in combating female cancers.

The problems of non-standard use of pesticides, and excessive pesticide residues and excessive heavy metal, etc. are common in the productive process of safflower (Carthamus tinctorius) and they are the factors restricting the sustainable development of safflower industry. Pollution-free production is an effective measure to ensure high quality of safflower. This paper summarized the environment of production area, selection of improved varieties for the production in the local places and its characteristics, the standardized comprehensive agronomic management and pollution-free rational fertilization technology. Additionally, the pollution-free control of safflower pests and diseases should follow the principle of priority to prevention and comprehensive prevention. Agricultural, biological and physical control should be preferred to use, and be combined with safe and low toxicity of chemical control. The standardization and industrialization of safflower production were realized by the construction of a comprehensive control technology system of pests and diseases of pollution-free safflower, which promoted the healthy development of the safflower plantation industry and achieved pollution-free standards.

Objective To investigate the expression variation of aquaporin in colon tissues in acute necrotizing pancreatitis (ANP).Methods ANP rat model was induced by the retrograde injection of sodium taurocholate into the biliopancreatic duct.The rats were killed at 4 h, 8 h, 12 h and 24 h after modeling with 6 rats for each time point.The pancreas and colon tissues were harvested for pathological examination.The levels of IL-6, TNF-α mRNA expression and AQR (aquaporin-3, aquaporin-4, aquaporin-8) mRNA expression in proximal and distant colon were detected by RT-PCR.The levels of aquaporin protein in colon were examined by immunohistochemistry.Results After the establishment of ANP SD rat model, the integrity of colonic mucosa was continuously damaged, the structure of epithelial cells was unclear and the colonic villus were broken and destroyed, and inflammatory cell infiltration in submucosa was observed.The pathological score increased with the time of modeling.In 4 h, except that the mRNA levels of AQP-4 in distal colon was not obviously changed, mRNA levels of IL-6 and TNF-α, mRNA and protein expression of AQP-3 and AQP-8 in the proximal and distal colon of ANP rats were significantly elevated compared with shame group (P<0.05).AQP-3 and AQP-8 mRNA in proximal colon of ANP rats reached its peak in 8 h after the establishment and AQP-4 mRNA peaked at 24 h.AQP-3 and AQP-4 mRNA in distant colon of ANP rats reached its peak in 8 h after the establishment and AQP-8 mRNA peaked at 24 h.Protein expression of AQP-3, AQP-4 and AQP-8 in proximal and distant colon was strongest in 12 h and 24 h after the establishment.Conclusions With the progression of the ANP, the expression levels of AQP-3, AQP-4 and AQP-8 in both proximal and distal colons were elevated in various degrees, indicating that the aquaporins may participate in water metabolism of colon during ANP.

Objective To investigate whether association of the genotype at the HLA A,B and DRB1, B3 B4 B5 loci with the Susceptipility to hemorrhagic fever with renal syndrome (HFRS) in Chinese Hans. Methods HLA A,B antigen types were detected by immunoserologic method and the genotypes of HLA DRB were identified by PCR/SSP method. Results The results showed that The Frequencies of A1, HLA DRB1 * (15,16) and DRB5 were increased in patients as compared to the healthy controls ( P