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Pristimerin, which is one of the compounds present in Celastraceae and Hippocrateaceae, has antitumor effects. However, its mechanism of action in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aims to investigate the efficacy and mechanism of pristimerin on ESCC in vitro and in vivo. The inhibitory effect of pristimerin on cell growth was assessed using trypan blue exclusion and colony formation assays. Cell apoptosis was evaluated by flow cytometry. Gene and protein expressions were analyzed through quantitative reverse transcription-polymerase chain reaction (qRT-PCR), Western blotting, and immunohistochemistry. RNA sequencing (RNA-Seq) was employed to identify significantly differentially expressed genes (DEGs). Cell transfection and RNA interference assays were utilized to examine the role of key proteins in pristimerin?s effect. Xenograft models were established to evaluate the antitumor efficiency of pristimerin in vivo. Pristimerin inhibited cell growth and induced apoptosis in ESCC cells. Upregulation of Noxa was crucial for pristimerin-induced apoptosis. Pristimerin activated the Forkhead box O3a (FoxO3a) signaling pathway and triggered FoxO3a recruitment to the Noxa promoter, leading to Noxa transcription. Blocking FoxO3a reversed pristimerin-induced Noxa upregulation and cell apoptosis. Pristimerin treatment suppressed xenograft tumors in nude mice, but these effects were largely negated in Noxa-KO tumors. Furthermore, the chemosensitization effects of pristimerin in vitro and in vivo were mediated by Noxa. This study demonstrates that pristimerin exerts an antitumor effect on ESCC by inducing AKT/FoxO3a-mediated Noxa upregulation. These findings suggest that pristimerin may serve as a potent anticancer agent for ESCC treatment.
Forkhead Box Protein O3/genetics* ; Humans ; Apoptosis/drug effects* ; Esophageal Squamous Cell Carcinoma/physiopathology* ; Esophageal Neoplasms/physiopathology* ; Pentacyclic Triterpenes ; Animals ; Cell Line, Tumor ; Proto-Oncogene Proteins c-bcl-2/genetics* ; Mice ; Signal Transduction/drug effects* ; Mice, Nude ; Cell Proliferation/drug effects* ; Triterpenes/pharmacology* ; Xenograft Model Antitumor Assays ; Mice, Inbred BALB C ; Male ; Gene Expression Regulation, Neoplastic/drug effects*

The management of chronic wounds presents significant challenges, characterized by a low rate of healing and substantial impairment of patients’ quality of life, while also exerting a considerable strain on healthcare resources. Wound healing is a multifactorial and dynamic process, necessitating close monitoring of wound changes and timely, appropriate interventions. Smart bandage/dressing, an innovative approach born from interdisciplinary research, offers a new generation of wound care. It enables dynamic quantitative monitoring of wound conditions, facilitates transdermal drug release and physical mode therapeutics, and adjusts interventions in real time based on monitoring outcomes. In comparison to traditional wound dressings, smart bandages exhibit attributes such as real-time responsiveness, precision, and convenience. They not only simplify wound management but also enhance patient comfort and compliance, showcasing potential as a safe and effective new treatment modality. Smart bandages hold promise for elevating the efficiency of managing chronic wounds, reducing morbidity rates, alleviating the burden of disease, and ultimately improving patients’ quality of life. This paper summarized the recent research progress of smart bandages and provide insights into novel wound care strategies.

Improvement of the jawline contour is a key focus in lower face and neck rejuvenation treatments. Achieving a well-defined, smooth jawline is a shared goal for both patients and plastic surgeons. This article reviews recent research on age-related changes of the jawline and evaluation method, offering valuable references for jawline rejuvenation treatments.The jawline's unique anatomical position, coupled with age-related changes, involves dynamic alterations in bone, soft tissue, and skin across multiple layers, making rejuvenation of this area a complex and challenging task. In recent years, advances in imaging technologies such as two-dimensional photography, three-dimensional stereophotogrammetry, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, and micro-CT have expanded the understanding of jawline anatomy and provided precise tools for analysis and evaluation.

Improvement of the jawline contour is a critical focus in lower face and neck rejuvenation treatments. Achieving a well-defined, smooth jawline is a shared goal between patients and plastic surgeons. This article reviewed recent research on age-related changes of the jawline and evaluation method, offering valuable references for jawline rejuvenation treatments.The jawline’s unique anatomical position, coupled with age-related changes, involves dynamic alterations in bone, soft tissue, and skin across multiple layers, making rejuvenation of this area a complex and challenging task. In recent years, advances in imaging technologies such as two-dimensional photography, three-dimensional stereophotogrammetry, computed tomography, magnetic resonance imaging, ultrasound, and micro-CT have expanded the understanding of jawline anatomy and provided precise tools for analysis and evaluation.

The management of chronic wounds presents significant challenges, characterized by a low rate of healing and substantial impairment of patients’ quality of life, while also exerting a considerable strain on healthcare resources. Wound healing is a multifactorial and dynamic process, necessitating close monitoring of wound changes and timely, appropriate interventions. Smart bandage/dressing, an innovative approach born from interdisciplinary research, offers a new generation of wound care. It enables dynamic quantitative monitoring of wound conditions, facilitates transdermal drug release and physical mode therapeutics, and adjusts interventions in real time based on monitoring outcomes. In comparison to traditional wound dressings, smart bandages exhibit attributes such as real-time responsiveness, precision, and convenience. They not only simplify wound management but also enhance patient comfort and compliance, showcasing potential as a safe and effective new treatment modality. Smart bandages hold promise for elevating the efficiency of managing chronic wounds, reducing morbidity rates, alleviating the burden of disease, and ultimately improving patients’ quality of life. This paper summarized the recent research progress of smart bandages and provide insights into novel wound care strategies.

Improvement of the jawline contour is a key focus in lower face and neck rejuvenation treatments. Achieving a well-defined, smooth jawline is a shared goal for both patients and plastic surgeons. This article reviews recent research on age-related changes of the jawline and evaluation method, offering valuable references for jawline rejuvenation treatments.The jawline's unique anatomical position, coupled with age-related changes, involves dynamic alterations in bone, soft tissue, and skin across multiple layers, making rejuvenation of this area a complex and challenging task. In recent years, advances in imaging technologies such as two-dimensional photography, three-dimensional stereophotogrammetry, computed tomography (CT), magnetic resonance imaging (MRI), ultrasound, and micro-CT have expanded the understanding of jawline anatomy and provided precise tools for analysis and evaluation.

Improvement of the jawline contour is a critical focus in lower face and neck rejuvenation treatments. Achieving a well-defined, smooth jawline is a shared goal between patients and plastic surgeons. This article reviewed recent research on age-related changes of the jawline and evaluation method, offering valuable references for jawline rejuvenation treatments.The jawline’s unique anatomical position, coupled with age-related changes, involves dynamic alterations in bone, soft tissue, and skin across multiple layers, making rejuvenation of this area a complex and challenging task. In recent years, advances in imaging technologies such as two-dimensional photography, three-dimensional stereophotogrammetry, computed tomography, magnetic resonance imaging, ultrasound, and micro-CT have expanded the understanding of jawline anatomy and provided precise tools for analysis and evaluation.

Cancer genomics has led to the discovery of numerous oncogenes and tumor suppressor genes that play critical roles in cancer development and progression.Oncogenes promote cell growth and proliferation,whereas tumor suppressor genes inhibit cell growth and division.The dysregulation of these genes can lead to the development of cancer.Recent studies have focused on non-coding RNAs(ncRNAs),including circular RNA(circRNA),long non-coding RNA(lncRNA),and microRNA(miRNA),as therapeutic targets for cancer.In this article,we discuss the oncogenes and tumor suppressor genes of ncRNAs associated with different types of cancer and their potential as therapeutic targets.Here,we highlight the mechanisms of action of these genes and their clinical applications in cancer treatment.Understanding the molecular mechanisms underlying cancer development and identifying specific therapeutic targets are essential steps towards the development of effective cancer treatments.