Objective:To develop one kind of alarm system with pressure sensor,so as to prevent compression injuries of patients with upper limb dysfunction due to the movement of the examination bed during computed tomography(CT)examination.Methods:The alarm system with pressure sensor was constructed on the basis of Arduino UNO open-source main control board and the HX711 weighing module.The Arduino E3 power supply module was used to provide power for system,and ESP8266 main control board was used to realize remote alarm,and its 3 dimension(3D)printed customized shell can directly be installed at the edge of examination bed.A total of 228 patients with upper limb dysfunction who underwent CT examination at Xianxian County Hospital of TCM during July 2022 and October 2022 were selected.They were randomly divided into observation group and control group by using a computer-generated random number sequence.The observation group was monitored for possibly potential compression risks on upper limb of patients by using the alarm system with pressure sensor.The patients of control group were respectively accompanied by one accompanying personnel to go into the scanning room,and they wore lead aprons,lead skirts,and other protective appliances for radiation protection.When a patient is found to be at risk of being crushed,an alarm should be raised by calling a halt.The valid alarm rates of the two alarm methods were calculated.Results:There were 37 times of alarm in observation group in examination,and 31 times were valid alarms and 6 times were invalid alarms in them.In control group,there were 49 times of alarm from accompanying personnel,and 29 times were valid alarms and 20 times were invalid alarms in 49 times of alarm.The valid alarm rate of observation group was significantly higher than that of control group,and the difference was statistically significant(x2=6.048,P<0.05).Conclusion:The installation of alarm system with pressure sensor is easy,and its use is convenient,and it has a higher valid alarm rate during CT examination,and it can effectively protect patients to prevent compression injuries.

Objective:To explore the current status and influencing factors of intrinsic capacity in elderly patients with Parkinson's disease.Methods:Convenience sampling was used to select 306 elderly patients with Parkinson's disease who attended Xuanwu Hospital of Capital Medical University from March to September 2024 for the study. Influencing factors were screened based on the health ecology model. Elderly patients with Parkinson's disease were surveyed using the General Information Questionnaire, Connor-Davidson Resilience Scale, Family APGAR Scale, Social Support Rating Scale, and Intrinsic Capacity Assessment Tool. Multiple linear regression was used to analyze the factors influencing the total score and the scores of each dimension of intrinsic capacity in elderly patients with Parkinson's disease.Results:A total of 306 questionnaires were distributed and 301 valid questionnaires were recovered, with a valid recovery rate of 98.37% (301/306). The total intrinsic capacity score of 301 elderly patients with Parkinson's disease was (67.21±11.47), of which 297 elderly patients with Parkinson's disease had impaired intrinsic capacity, and the rate of impaired intrinsic capacity was 98.7% (297/301). The dimensions in descending order of impairment were motor [89.7% (270/301) ], mental [76.1% (229/301) ], sensory [70.4% (212/301) ], vitality [38.2% (115/301) ], and cognitive [25.6% (77/301) ]. Multiple linear regression analysis showed that age, Hoehn-Yahr staging, levodopa equivalent dosage, activity of daily living, history of falls, regular exercise, psychological resilience, social support, and monthly income were the factors influencing the total intrinsic capacity score of elderly patients with Parkinson's disease ( P<0.05) and heterogeneity of influencing factors in each dimension. Conclusions:Elderly patients with Parkinson's disease have a high rate of impaired intrinsic capacity, with the motor dimension being the most severely impaired. Healthcare professionals should pay attention to the assessment of the intrinsic capacity of elderly patients with Parkinson's disease, and customize interventions according to the influencing factors to promote the functioning of elderly patients so as to reduce the burden of care on families and society.

Objective:To develop one kind of alarm system with pressure sensor,so as to prevent compression injuries of patients with upper limb dysfunction due to the movement of the examination bed during computed tomography(CT)examination.Methods:The alarm system with pressure sensor was constructed on the basis of Arduino UNO open-source main control board and the HX711 weighing module.The Arduino E3 power supply module was used to provide power for system,and ESP8266 main control board was used to realize remote alarm,and its 3 dimension(3D)printed customized shell can directly be installed at the edge of examination bed.A total of 228 patients with upper limb dysfunction who underwent CT examination at Xianxian County Hospital of TCM during July 2022 and October 2022 were selected.They were randomly divided into observation group and control group by using a computer-generated random number sequence.The observation group was monitored for possibly potential compression risks on upper limb of patients by using the alarm system with pressure sensor.The patients of control group were respectively accompanied by one accompanying personnel to go into the scanning room,and they wore lead aprons,lead skirts,and other protective appliances for radiation protection.When a patient is found to be at risk of being crushed,an alarm should be raised by calling a halt.The valid alarm rates of the two alarm methods were calculated.Results:There were 37 times of alarm in observation group in examination,and 31 times were valid alarms and 6 times were invalid alarms in them.In control group,there were 49 times of alarm from accompanying personnel,and 29 times were valid alarms and 20 times were invalid alarms in 49 times of alarm.The valid alarm rate of observation group was significantly higher than that of control group,and the difference was statistically significant(x2=6.048,P<0.05).Conclusion:The installation of alarm system with pressure sensor is easy,and its use is convenient,and it has a higher valid alarm rate during CT examination,and it can effectively protect patients to prevent compression injuries.

Objective:To explore the current status and influencing factors of intrinsic capacity in elderly patients with Parkinson's disease.Methods:Convenience sampling was used to select 306 elderly patients with Parkinson's disease who attended Xuanwu Hospital of Capital Medical University from March to September 2024 for the study. Influencing factors were screened based on the health ecology model. Elderly patients with Parkinson's disease were surveyed using the General Information Questionnaire, Connor-Davidson Resilience Scale, Family APGAR Scale, Social Support Rating Scale, and Intrinsic Capacity Assessment Tool. Multiple linear regression was used to analyze the factors influencing the total score and the scores of each dimension of intrinsic capacity in elderly patients with Parkinson's disease.Results:A total of 306 questionnaires were distributed and 301 valid questionnaires were recovered, with a valid recovery rate of 98.37% (301/306). The total intrinsic capacity score of 301 elderly patients with Parkinson's disease was (67.21±11.47), of which 297 elderly patients with Parkinson's disease had impaired intrinsic capacity, and the rate of impaired intrinsic capacity was 98.7% (297/301). The dimensions in descending order of impairment were motor [89.7% (270/301) ], mental [76.1% (229/301) ], sensory [70.4% (212/301) ], vitality [38.2% (115/301) ], and cognitive [25.6% (77/301) ]. Multiple linear regression analysis showed that age, Hoehn-Yahr staging, levodopa equivalent dosage, activity of daily living, history of falls, regular exercise, psychological resilience, social support, and monthly income were the factors influencing the total intrinsic capacity score of elderly patients with Parkinson's disease ( P<0.05) and heterogeneity of influencing factors in each dimension. Conclusions:Elderly patients with Parkinson's disease have a high rate of impaired intrinsic capacity, with the motor dimension being the most severely impaired. Healthcare professionals should pay attention to the assessment of the intrinsic capacity of elderly patients with Parkinson's disease, and customize interventions according to the influencing factors to promote the functioning of elderly patients so as to reduce the burden of care on families and society.

Objective To identify the relationship between physical activity,insulin resistance and cardiovascular risk in individuals with different glucose tolerance status and to provide evidence for exercise intervention in people with different glucose tolerance status.Methods A total of 691 patients with different glucose metabolism status were recruited as subjects of the research.Spearman correlation analysis was used to study the relationship between exercise frequency and insulin resistance,insulin sensitivity,neck circumference(NC)and neck circumference height ratio(NHtR)in the subjects with different glucose metabolism status,the relationship between NC and insu-lin resistance and insulin sensitivity in different glucose metabolism groups.Results 171(62.9%)Subjects with diabetes were intervened by exercised every day.Spearman correlation analysis showed the correlation between exer-cise frequency and tri-glyceride triglyceride-glucose index(TyG index)(r=-0.120,P＜0.05)and NC(r=-0.168,P＜0.05)were negatively correlated.In subjects with diabetes,NC was positively correlated with triglyc-erides(TG)(r=-0.100,P＜0.05),homeostasis model assessment of insulin resistance(HOMA-R)(r=-0.163,P＜0.05),total cholesterol/high-density lipoprotein(TC/HDL-C)(r=-0.214,P＜0.05)and TyG index(r=-0.156,P＜0.05).Conclusions Increased frequency of exercise is associated with reduced NC,improved insulin resistance,and cardiovascular risk factors in subjects of our team with newly diagnosed diabetes.Exercise has no significant effect on insulin resistance of subjects with normal glucose tolerance and pre-diabetes.

Background Lipid metabolism in liver shows circadian-dependent profiles. The hepatotoxicity of environmental chemicals is dependent on circadian time. Objective To observe the effects of bisphenol A (BPA) exposure at different zeitgeber time (ZT) on hepatic and blood lipid metabolism and decipher the underlying mechanisms related to circadian rhythm in mice. Methods Thirty-five female C57BL/6J mice were sacrificed every 4 h in a light-dark cycle (12 h/12 h). The liver tissues were collected to describe the circadian profiles of hepatic Rev-erba, Bmal1, Clock, Srebp1c, and Chrebp mRNA expression levels within 24 h. Thirty female mice were divided into 6 groups by the timing (ZT3 represents the 3 h after light on, ZT15 represents the 3 h after light off) and dose (50 or 500 μg·kg⁻¹·d⁻¹) of BPA exposure to observe hepatotoxicity. Mice were gavaged with designed doses of BPA once per day for 4 weeks. Mice were maintained with ad libitum access to food and water and measured body weight weekly. After the experiment, mice were euthanatized and liver tissues were separated to determine the biochemical indicators of lipid metabolism and lipid metabolism- and circadian-related gene mRNA expressions. Results Hepatic Rev-erba, Bmal1, Clock, Srebp1c, and Chrebp mRNA expression levels were rhythmic during a 24 h period in mice. At ZT3 and ZT15, BPA did not alter body weight, plasma glucose, plasma total cholesterol, plasma low density lipoprotein cholesterol, and plasma triglycerides (P>0.05). The plasma high density lipoprotein cholesterol decreased in the 50 μg·kg⁻¹·d⁻¹ BPA group at ZT3 by 14.56% compared with the control group (P<0.05). The liver triglycerides increased in the 50 μg·kg⁻¹·d⁻¹ BPA group at ZT15 by 115.20% compared with the control group (P<0.05). BPA decreased Srebp1c mRNA expression level when dosing at ZT3 and increased Chrebp, Srebp1c, and Acc1 mRNA expression levels when dosing at ZT15 compared with the control group (P<0.05). BPA increased Bmal1 mRNA expression level and decreased Rev-erbα mRNA expression level at ZT3 exposure and decreased Bmal1 and increased Rev-erbα mRNA expression level at ZT15 exposure (P<0.05). Conclusion BPA exposure at light or dark period has different effects on hepatic lipid metabolism in mice. Hepatic lipid deposit appears when BPA is dosed at dark period. Rev-erbα-Bmal1 regulation circuits and the subsequent upregulation of Srebp1c and Chrebp and the target gene Acc1 may be involved.

Objective:To analyze the bibliometric indicators of Chinese Journal of Nautical Medicine and Hyperbaric Medicine from 2014 to 2018, so as to improve its academic level and influence. Methods:Based on the statistical data from the core edition of the Chinese S& T Journal Citation Reports and part of the data provided by Wanfang Database Journal Bibliometric Evaluation Center, the changes of bibliometric indicators of Chinese Journal of Nautical Medicine and Hyperbaric Medicine from 2014 to 2018 were analyzed, including the impact factor, the citation frequency, the immediacy index, the cited half-life, the amount of published papers, the ratio of funded papers, and the number of papers published by high impact authors. Results:Among the cited indicators of the journal from 2014 to 2018, the impact factor showed an increasing trend year by year, and the highest year was in 2018 (0.757); the lowest citation frequency was in 2014 (86 times), the highest one was in 2018 (148 times), and there was a slightly fluctuation of that from 2015 to 2017; the lowest immediacy index was in 2014 (0.055), the highest one was in 2017 (0.105), and there was a slight decrease in the immediacy index in 2018 compared with that in 2017; the cited half-life showed a decreasing trend year by year, with the highest in 2014 (6.4 years) and the lowest in 2018 (4.3 years); among the source indicators, the amount of published papers slightly fluctuated from 2014 to 2018, with the lowest in 2018 (129 articles) and the highest in 2015 (187 articles); the highest ratio of funded papers was in 2015 (38.0%, 71/187) and the lowest was in 2016 (19.8%, 34/172); from 2014 to 2018, the number of papers published by high impact authors decreased year by year, with the highest in 2014 and 2015 (both were 94 articles) and the lowest in 2018 (39 articles).Conclusion:The bibliometric indicators of Chinese Journal of Nautical Medicine and Hyperbaric Medicine from 2014 to 2018 are generally good, and the information output, academic influence and level of the journal are steadily improving. Yet, more active measures should be taken to maintain and improve the academic quality of papers published on the journal to increase its academic influence and international dissemination.

Objective:To analyze the bibliometric indicators of Chinese Journal of Nautical Medicine and Hyperbaric Medicine from 2014 to 2018, so as to improve its academic level and influence. Methods:Based on the statistical data from the core edition of the Chinese S& T Journal Citation Reports and part of the data provided by Wanfang Database Journal Bibliometric Evaluation Center, the changes of bibliometric indicators of Chinese Journal of Nautical Medicine and Hyperbaric Medicine from 2014 to 2018 were analyzed, including the impact factor, the citation frequency, the immediacy index, the cited half-life, the amount of published papers, the ratio of funded papers, and the number of papers published by high impact authors. Results:Among the cited indicators of the journal from 2014 to 2018, the impact factor showed an increasing trend year by year, and the highest year was in 2018 (0.757); the lowest citation frequency was in 2014 (86 times), the highest one was in 2018 (148 times), and there was a slightly fluctuation of that from 2015 to 2017; the lowest immediacy index was in 2014 (0.055), the highest one was in 2017 (0.105), and there was a slight decrease in the immediacy index in 2018 compared with that in 2017; the cited half-life showed a decreasing trend year by year, with the highest in 2014 (6.4 years) and the lowest in 2018 (4.3 years); among the source indicators, the amount of published papers slightly fluctuated from 2014 to 2018, with the lowest in 2018 (129 articles) and the highest in 2015 (187 articles); the highest ratio of funded papers was in 2015 (38.0%, 71/187) and the lowest was in 2016 (19.8%, 34/172); from 2014 to 2018, the number of papers published by high impact authors decreased year by year, with the highest in 2014 and 2015 (both were 94 articles) and the lowest in 2018 (39 articles).Conclusion:The bibliometric indicators of Chinese Journal of Nautical Medicine and Hyperbaric Medicine from 2014 to 2018 are generally good, and the information output, academic influence and level of the journal are steadily improving. Yet, more active measures should be taken to maintain and improve the academic quality of papers published on the journal to increase its academic influence and international dissemination.