Objective To investigate an automated pretreatment technology for detecting levels of free silica in workplace dust. Methods An fully automated pretreatment workstation for detecting free silica levels in workplace dust was developed by integrating graphite-controlled digestion temperature, online-controlled dilution of digestion solutions, and filtration endpoint recognition based on monitoring technology, combined with multi-channel synchronous measurements. Results The fully automatic pretreatment workstation was used to digest and filter 14 standard samples of free silica produced by three institutions, and then detected by pyrophosphate method. The result range of high-, medium-, and low-level free silica standard samples detection was 66.5%-84.8%, 40.0%-44.5%, and 2.1%-24.8%, respectively. The mean relative standard deviations were 3.9%, 1.4% and 1.5%. Conclusion The fully automated pretreatment workstation produced results that met relevant requirements. It can effectively replace the manual digestion and filtration steps of the pyrophosphate method to measure free silica levels in workplace dust and enable rapid detection of free silica in dust samples.

Sonodynamic therapy (SDT) provides a non-invasive therapeutic strategy for killing tumor cells by using low-intensity ultrasound combined with sonosensitizer. Compared with other tumors, urinary system tumors have a good sound window for treatment. Combined with the advantages of low-frequency ultrasound, such as strong penetration and high targeting, SDT has efficient treatment efficiency and broad application prospects in urological tumors.

Objective:To evaluate the efficacy and safety of oral anisodine hydrobromide tablets in the treatment of nonarteritic anterior ischemic optic neuropathy (NAION).Methods:A multicenter nonrandomized controlled trial was conducted.A total of 282 acute NAION patients (282 eyes) were recruited from 16 hospitals in China from July 2020 to May 2021.Patients were divided into two groups according to treatment methods, which were control group (124 cases, 124 eyes) receiving regular treatment including citicoline sodium plus Ginkgo biloba leaf liquid extract or Ginkgo biloba leaf extract tablets plus mecobalamin, and experimental group (158 cases, 158 eyes) receiving treatment in control group plus oral anisodine hydrobromide tablets 1 mg, twice daily for 2 to 3 months.Best corrected visual acuity (BCVA), visual field index (VFI), peripapillary retinal nerve fiber layer (pRNFL) and radial peripapillary capillary vessel density (RPC) were assessed at 1, 2, 3, and 6 months after enrollment using the standard decimal visual acuity chart, 750i Humphery visual field analyzer, Cirrus HD-OCT 4000/Cirrus HD-OCT 5000, RTVue-XR optical coherence tomography respectively.The primary outcomes were BCVA and VFI, and the secondary outcomes were pRNFL, RPC, and the side effects during the follow-up.The study adhered to the Declaration of Helsinki.All patients were fully informed about the treatment and purpose of this study and voluntarily signed the informed consent form.The study protocol was approved by Chinese PLA General Hospital (No.S2020-021-01). Results:In all, 242 patients (242 eyes) completed the follow-up of BCVA, and 98 patients (98 eyes) completed the VFI follow-up.In terms of visual function, BCVA and VFI improved significantly over time in the two groups, and BCVA and VFI were better in experimental group than in control group at various follow-up time points (all at P<0.05). In terms of structure, pRNFL gradually decreased in both groups with the extension of treatment, and pRNFL was significanthy thinner in experimental group than in control group at various follow-up time points (all at P<0.05). There was no significant difference in RPC between the two groups at the last follow-up ( P>0.05). There were two cases with side effects and one case was discontinued due to side effects 25 days after enrollment. Conclusions:Oral anisodine hydrobromide can improve visual acuity and visual field in NAION and accelerate the regression of optic disc edema, with good safety.

Objective To compare the clinical effect of laparoscopic high-ligation of inguinal hernia sac and routine surgery in treating children with inguinal hernia.Methods Totally 60 children with inguinal hernia were divided into laparoscopy group and routine operation group.Laparoscopy group was treated with laparoscopic high-ligation of hernia sac,while routine operation group was treated with traditional high-ligation of hernia sac.The general operation indexes,complications and recurrence condition were compared between two groups.Results The length of incision,intraoperative bleeding,operation time and time of hospitalization in laparoscopy group were significantly lower than the control group (P ＜ 0.05).There was no significant difference in cost of hospitalization between two groups (P ＞ 0.05).In the laparoscopy group,detection rate of contralateral occult hernia was significantly higher than the control group (P ＜ 0.05).The incidence rate of complications was significantly lower than the control group (P ＜ 0.05).There was no significant difference in the recurrence rate between two groups (P ＞ 0.05).Conclusion Compared with conventional surgery,laparoscopic high-ligation of hernia sac can shorten operation time and hospitalization time,and reduce postoperative complications.

Objective To compare the clinical effect of laparoscopic high-ligation of inguinal hernia sac and routine surgery in treating children with inguinal hernia.Methods Totally 60 children with inguinal hernia were divided into laparoscopy group and routine operation group.Laparoscopy group was treated with laparoscopic high-ligation of hernia sac,while routine operation group was treated with traditional high-ligation of hernia sac.The general operation indexes,complications and recurrence condition were compared between two groups.Results The length of incision,intraoperative bleeding,operation time and time of hospitalization in laparoscopy group were significantly lower than the control group (P ＜ 0.05).There was no significant difference in cost of hospitalization between two groups (P ＞ 0.05).In the laparoscopy group,detection rate of contralateral occult hernia was significantly higher than the control group (P ＜ 0.05).The incidence rate of complications was significantly lower than the control group (P ＜ 0.05).There was no significant difference in the recurrence rate between two groups (P ＞ 0.05).Conclusion Compared with conventional surgery,laparoscopic high-ligation of hernia sac can shorten operation time and hospitalization time,and reduce postoperative complications.

Objective To obeserve the influence of comprehensive intervention on ventilator associated pneumonia (VAP) in neonatal iatensive care unit. Methods From January 2013 to January 2014, 98 neonates received intubation and mechanical ventilation in neonatal intensive care unit (NICU) were selected and divided into treatment group and control group by 1:1 matched case-control study. And each group had 49 neonates. Preventive factors of treatment group were included levating patient's head and chest to 30 degrees to the horizontal level, closed endotracheal suction systems, washing hands, intensiving frequency of oral-pharyngeal nursing with thorough suction, changing ventiahor tube after three days. While the control group was given routine intervention. The incidence of VAP, the length of hos-pital stay and ventilator time were measured and compared between two groups. Results Compared with control group, neonates in treatment group had lower incidence of VAP (10.20%v s 28.57%) and shorter ventilator time [(60.36±9.23) h vs (67.52±8.55h)]. There was difference on hospital stay between the two groups(P<0.05). Conclusion The preventive factors including levating patient's head and chest to at least 30 degrees to the horizontal level, closed endotracheal suction systems, washing hands, intensiving frequency of oral-pharyngeal nursing with thorough suction, changing venti-ahor tube after three days can reduce incidence of ventilator-associated pneumonia, shorten ventilator time and length of hospital stay.