Objective To explore the clinical characteristics of head deformities in infants aged 3-12 months and analyze the related factors that affect infant positional deformities.Methods A total of 521 infants aged 3-12 months from August 2022 to February 2024 in the Third Affiliated Hospital of Zhengzhou University were selected as the subjects.Infants were divided into normal groups(n=307)and positional deformities(n=214)according to the head shape assessment.The general,high-risk factors during pregnancy,mother's education level and baby's sleeping posture were compared between the two groups.Logistic regression was used to analyze the influencing factors of positional deformities.Results Among infants with positional deformities,it was more common at the age of 3-6 months,and the proportion of males was higher than that of females.There were significant differences in the factors such as birth weight,body mass index(BMI),premature delivery,hospitalization history in neonatal intensive care unit(NICU),high-risk factors during pregnancy,twins,sleeping posture,and mother's education level between two groups(P<0.05).Multivariate Logistic regression analysis showed that hospitalization history in NICU,twins,high-risk factors during pregnancy were independent risk factors for infant's positional deformities.Infant's mixed sleeping position and mother's high education level were the protective factors against the infant's positional deformities.Conclusion BMI,hospitalization history in NICU,twins,high-risk factors during pregnancy,infant sleeping posture and mother's education level are closely related to the infant's positional deformities.

Objective To explore the clinical characteristics of head deformities in infants aged 3-12 months and analyze the related factors that affect infant positional deformities.Methods A total of 521 infants aged 3-12 months from August 2022 to February 2024 in the Third Affiliated Hospital of Zhengzhou University were selected as the subjects.Infants were divided into normal groups(n=307)and positional deformities(n=214)according to the head shape assessment.The general,high-risk factors during pregnancy,mother's education level and baby's sleeping posture were compared between the two groups.Logistic regression was used to analyze the influencing factors of positional deformities.Results Among infants with positional deformities,it was more common at the age of 3-6 months,and the proportion of males was higher than that of females.There were significant differences in the factors such as birth weight,body mass index(BMI),premature delivery,hospitalization history in neonatal intensive care unit(NICU),high-risk factors during pregnancy,twins,sleeping posture,and mother's education level between two groups(P<0.05).Multivariate Logistic regression analysis showed that hospitalization history in NICU,twins,high-risk factors during pregnancy were independent risk factors for infant's positional deformities.Infant's mixed sleeping position and mother's high education level were the protective factors against the infant's positional deformities.Conclusion BMI,hospitalization history in NICU,twins,high-risk factors during pregnancy,infant sleeping posture and mother's education level are closely related to the infant's positional deformities.

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Fat accumulation "sensitizes" the liver to insult and leads to nonalcoholic steatohepatitis (NASH). G protein-coupled receptor 35 (GPR35) is involved in metabolic stresses, but its role in NAFLD is unknown. We report that hepatocyte GPR35 mitigates NASH by regulating hepatic cholesterol homeostasis. Specifically, we found that GPR35 overexpression in hepatocytes protected against high-fat/cholesterol/fructose (HFCF) diet-induced steatohepatitis, whereas loss of GPR35 had the opposite effect. Administration of the GPR35 agonist kynurenic acid (Kyna) suppressed HFCF diet-induced steatohepatitis in mice. Kyna/GPR35 induced expression of StAR-related lipid transfer protein 4 (STARD4) through the ERK1/2 signaling pathway, ultimately resulting in hepatic cholesterol esterification and bile acid synthesis (BAS). The overexpression of STARD4 increased the expression of the BAS rate-limiting enzymes cytochrome P450 family 7 subfamily A member 1 (CYP7A1) and CYP8B1, promoting the conversion of cholesterol to bile acid. The protective effect induced by GPR35 overexpression in hepatocytes disappeared in hepatocyte STARD4-knockdown mice. STARD4 overexpression in hepatocytes reversed the aggravation of HFCF diet-induced steatohepatitis caused by the loss of GPR35 expression in hepatocytes in mice. Our findings indicate that the GPR35-STARD4 axis is a promising therapeutic target for NAFLD.

Objective:To explore the relationship between aortic arch calcification (AoAC) and arteriovenous fistula (AVF) failure in maintenance hemodialysis (MHD) patients.Methods:The patients who underwent initial AVF and started MHD in the General Hospital of Ningxia Medical University from September 2016 to September 2017 were retrospectively recruited and prospectively followed up until two years after AVF surgery or withdrawal from MHD or death. Calcification of the aortic arch was estimated with plain chest radiology. The patients were divided into four groups (0-3 grade) according to the aortic arch calcification score (AoACs). Spearman correlation analysis was used to analyze the relationship between AoACs and AVF failure. Multivariate logistic regression was used to analyze the influencing factors of AVF failure.Results:A total of 165 MHD patients were included in this study, with age of (55.52±14.06) years old and 102 males (61.82%). Among 128 AoAC patients (77.6%), 45 patients were categorized as grade 1 (27.3%), 35 patients as grade 2 (21.2%) and 48 patients as grade 3 (29.1%). There was significant difference in the, age, pulse pressure, corrected calcium, phosphorus, diastolic blood pressure, intact parathyroid hormone and AVF failure between AoAC group and no AoAC group (grade 0 calcification) (all P<0.05). The results of Spearman correlation analysis showed that AoACs was positively correlated with AVF failure ( r=0.759, P=0.010), age ( r=0.407, P<0.001), pulse pressure ( r=0.575, P=0.006), and diabetes history ( r=0.848, P=0.049), blood calcium ( r=0.591, P=0.018), and blood phosphorus ( r=0.509, P=0.012), and negatively correlated with diastolic blood pressure ( r=-0.614, P=0.013). Multivariate logistic regression analysis showed that diabetes history ( OR=6.702, 95% CI 1.431-31.396, P=0.016), high corrected calcium ( OR=10.830, 95% CI 3.479-35.300, P=0.008), high phosphorus ( OR=3.792, 95% CI 1.128-12.750, P=0.031) and AoAC ( OR=4.473, 95% CI 1.490-13.428, P=0.008) were the independent influencing factors of AVF failure. Conclusions:AoAC is an independent risk factor for AVF failure in MHD patients. Evaluation of AoAC has predictive value for AVF failure.