Objective To compare the clinical efficacy of the pull technique with routine extubation for peritoneal dialysis(PD)catheter removal.Methods A retrospective analysis was conducted on 81 PD patients who were admitted to the Affiliated People's Hospital of Ningbo University from January 2017 to August 2024 and were scheduled to undergo PD catheter removal.They were divided into conventional extubation group(n=43)and pull technique extubation group(n=38)based on the method of catheter removal.The conventional extubation group adopts open surgical extubation,while the pull technique extubation group adopts pull technique extubation.Comparative analysis of perioperative indicators and postoperative complications between two groups of patients.Results The surgical time,intraoperative blood loss,and hospital stay of patients in pull technique extubation group were significantly better than those in conventional extubation group(P＜0.001).The score of the immediate postoperative and 24-hour postoperative numerical rating scale were significantly lower than those of conventional extubation group(P＜0.001).There was no statistically significant difference in the surgical site infection rate and the total incidence of postoperative complications at 6 months between two groups of patients(P＞0.05).Conclusion As a minimally invasive approach,the pull technique offers advantages including reduced tissue trauma,faster recovery,and lower medical costs,making it a preferred option for PD catheter removal.

Objective To compare the clinical efficacy of the pull technique with routine extubation for peritoneal dialysis(PD)catheter removal.Methods A retrospective analysis was conducted on 81 PD patients who were admitted to the Affiliated People's Hospital of Ningbo University from January 2017 to August 2024 and were scheduled to undergo PD catheter removal.They were divided into conventional extubation group(n=43)and pull technique extubation group(n=38)based on the method of catheter removal.The conventional extubation group adopts open surgical extubation,while the pull technique extubation group adopts pull technique extubation.Comparative analysis of perioperative indicators and postoperative complications between two groups of patients.Results The surgical time,intraoperative blood loss,and hospital stay of patients in pull technique extubation group were significantly better than those in conventional extubation group(P＜0.001).The score of the immediate postoperative and 24-hour postoperative numerical rating scale were significantly lower than those of conventional extubation group(P＜0.001).There was no statistically significant difference in the surgical site infection rate and the total incidence of postoperative complications at 6 months between two groups of patients(P＞0.05).Conclusion As a minimally invasive approach,the pull technique offers advantages including reduced tissue trauma,faster recovery,and lower medical costs,making it a preferred option for PD catheter removal.

Objective:To explore the HIV-1 drug resistance and subtypes in newly reported HIV/AIDS patients before antiretroviral therapy (ART) in Taizhou city.Methods:A cross-sectional study of HIV-1 drug resistance was conducted among newly reported HIV/AIDS patients before ART in Taizhou from January 2016 to December 2018. HIV-1 pol gene sequences were obtained by RT-PCR. The sequences were submitted to the Stanford University drug resistance database. The drug resistance mutation and the sensitivity of HIV-1 strains to antiretroviral drugs were determined according to WHO Guidelines on HIV drug resistance surveillance of 2014. Results:A total of 806 HIV-1 pol gene sequences were obtained successfully. The overall HIV-1 drug resistance rate was 2.9% (23/806), 1.9% for non-nucleoside reverse transcriptase inhibitors (NNRTIs), 0.6% for nucleoside reverse transcriptase inhibitors (NRTIs), and 0.0% for protease inhibitors (PIs), respectively. From 2016 to 2018, the HIV-1 drug resistance rate was 1.6%, 1.8%, and 4.8%, respectively. The resistance mutations of NNRTIs and NRTIs were mainly K103 N (0.7%) and M184I/V (0.5%). HIV-1 subtypes were mostly CRF01_AE (42.7%,344/806),CRF07_BC (28.9%,233/806) and CRF08_BC (11.2%,90/806).HIV-1 subtypes among homosexually transmitted infections were mostly CRF01_AE (53.3%, 136/255) and CRF07_BC (32.2%, 82/255), and HIV-1 subtypes among heterosexually transmitted infections were mainly CRF01_AE (37.7%, 203/539), CRF07_BC (27.5%, 148/539) and CRF08_BC (16.1%, 87/539). Conclusion:HIV-1 drug resistance rate among newly reported HIV/AIDS patients before ART remained low in Taizhou during 2016 to 2018, an increasing trend seemed to be notifiable and warrants continuous surveillance of HIV-1 drug resistance.

Objective To examine the prevalence and correlates of hepatitis C virus (HCV) co-infection as well as plasma HCV viral load among newly diagnosed HIV-infected adults during 2009-2012 in Taizhou prefecture of Zhejiang province,China.Methods Five hundred and seventy-two adults who were newly diagnosed as HIV-infection were screened for anti-HCV immunoglobulin G (IgG).Plasma HCV RNA was quantified if positive for HCV IgG.Results Forty-two (7.3％) out of the 572 HIV-infected adults were tested positive for HCV IgG.HCV infection was more likely to occur among participants who were infected with HIV through blood transmission (OR=49.46,95％CI:13.71-178.48).Otherwise,HCV infection was less likely to occur among participants who were under 46-86 years of age (OR=0.12,95％CI:0.02-0.58),those with mode of homosexual transmission of HIV (OR=0.11,95％ C I:0.01-0.86),with education of high school or above (OR=0.13,95％ CI:0.02-0.78).Thirty-three (78.6％) of the total 42 HIV-HCV patients with coinfection had detectable plasma HCV RNA,whereas 9 (21.4％) had undetectable plasma HCV RNA (i.e.,lower than 5.0 × 102 IU/ml) or known as relative HCV viral suppression.No significant associations were noticed on factors as:HCV viral suppression and demographics,HIV transmission route and CD4 + T-cell counts according to univariate regression analyses.Conclusion Prevalence of HCV co-infection was relatively high among newly diagnosed HIV-infected adults in this study area.Majority of the HIV-HCV coinfected patients had detectable plasma HCV RNA,of which the long term impact on disease progression deserves called for further research.