Post-stroke aphasia (PSA) severely impairs patients' daily communication with family members, thereby affecting the overall rehabilitation process and quality of life. This study aims to systematically review domestic and international research on family communication among PSA patients, covering overviews, measurement tools, influencing factors, and intervention strategies. Additionally, it proposes future research directions to provide references for conducting relevant studies and practices on family communication in PSA patients within the current cultural context.

Post-stroke aphasia (PSA) severely impairs patients' daily communication with family members, thereby affecting the overall rehabilitation process and quality of life. This study aims to systematically review domestic and international research on family communication among PSA patients, covering overviews, measurement tools, influencing factors, and intervention strategies. Additionally, it proposes future research directions to provide references for conducting relevant studies and practices on family communication in PSA patients within the current cultural context.

Objective To investigate the effect of bear bile powder(BBP)and ursodeoxycholic acid(UDCA)on preneoplastic lesions of hepatocarcinoma,using short-term carcinogenesis bioassay models.Methods Forty 6-week-old male SD rats were divided randomly into control,diethylnitrosamine(DEN),DEN+BBP(200 mg/kg),and DEN+UDCA(30 mg/kg)groups.All rats,except for the control group,were injected intraperitoneally with 100 mg/kg DEN once a week for 3 weeks.Rats in the DEN+BBP and DEN+UDCA groups also received oral BBP 200 mg/kg or UDCA 30 mg/kg suspended solution,respectively,daily from the beginning to the end of the experiment.Results There were no significant differences in body or liver weights between the DEN,DEN+BBP,and DEN+UDCA groups.DEN treatment increased the accumulation of malondialdehyde(MDA),decreased superoxide dismutase(SOD),and reduced glutathione(GSH)activities in liver tissue,while UDCA enhanced SOD and GSH activities and decreased MDA accumulation in liver tissue.In contrast,BBP exerted these antioxidant effects in serum.The number and area of glutathione S-transferase placental(GST-P)type-positive lesions and the Ki-67-positive cell ratio were significantly lower in the DEN+BBP and DEN+UDCA groups than in the DEN group,especially in the DEN+UDCA group.UDCA significantly increased Caspase-9 mRNA expression compared with the model group.Conclusions BBP and UDCA have significant inhibitory effects on preneoplastic lesions of hepatocarcinoma induced by DEN,and both have antioxidant effects on DEN-induced oxidative stress.The antioxidant mechanisms of BBP and UDCA differ,however,and further research is needed to determine the roles of the antioxidant effects in their anticancer mechanisms.

Objective To investigate the effect of bear bile powder(BBP)and ursodeoxycholic acid(UDCA)on preneoplastic lesions of hepatocarcinoma,using short-term carcinogenesis bioassay models.Methods Forty 6-week-old male SD rats were divided randomly into control,diethylnitrosamine(DEN),DEN+BBP(200 mg/kg),and DEN+UDCA(30 mg/kg)groups.All rats,except for the control group,were injected intraperitoneally with 100 mg/kg DEN once a week for 3 weeks.Rats in the DEN+BBP and DEN+UDCA groups also received oral BBP 200 mg/kg or UDCA 30 mg/kg suspended solution,respectively,daily from the beginning to the end of the experiment.Results There were no significant differences in body or liver weights between the DEN,DEN+BBP,and DEN+UDCA groups.DEN treatment increased the accumulation of malondialdehyde(MDA),decreased superoxide dismutase(SOD),and reduced glutathione(GSH)activities in liver tissue,while UDCA enhanced SOD and GSH activities and decreased MDA accumulation in liver tissue.In contrast,BBP exerted these antioxidant effects in serum.The number and area of glutathione S-transferase placental(GST-P)type-positive lesions and the Ki-67-positive cell ratio were significantly lower in the DEN+BBP and DEN+UDCA groups than in the DEN group,especially in the DEN+UDCA group.UDCA significantly increased Caspase-9 mRNA expression compared with the model group.Conclusions BBP and UDCA have significant inhibitory effects on preneoplastic lesions of hepatocarcinoma induced by DEN,and both have antioxidant effects on DEN-induced oxidative stress.The antioxidant mechanisms of BBP and UDCA differ,however,and further research is needed to determine the roles of the antioxidant effects in their anticancer mechanisms.

ObjectiveTo investigate the correlation of miR-181c expression in peripheral blood mononuclear cells (PBMCs) with interferon-γ (IFN-γ), chemokine (C-X-C motif) ligand 10 (CXCL10), and Toll-like receptor 4 (TLR4) in children with autoimmune hepatitis (AIH). MethodsA total of 27 children with AIH who were admitted to The Affiliated Hospital of Yanbian University from March 2015 to May 2019 were enrolled as AIH group, and 30 healthy children who underwent physical examination during the same period of were enrolled as control group. The expression of miR-181c in PBMCs and the expression of IFN-γ, CXCL10, and TLR4 were measured for the two groups. The t-test was used for comparison of normally distributed continuous data between two groups, and the Wilcoxon rank-sum test was used for comparison of non-normally distributed continuous data between two groups; the chi-square test was used for comparison of categorical data between two groups. The Pearson correlation coefficient was used to investigate the correlation of miR-181c expression with each index, and a logistic regression analysis was used to investigate the influence of each factor on AIH. ResultsCompared with the control group, the AIH group had significantly higher levels of the liver function parameters aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), and total bilirubin (TBil) (t=14.445,20.064，11.728,13.822, all P＜0.001). The AIH group also had significantly higher levels of IgA, IgM, and IgG than the control group (t=7.772, 5147, and 6771, all P＜0.05). The AIH group had significantly lower relative expression of miR-181c in PBMCs than the control group (0.784±0173 vs 1.106±0.224, t=5.819, P＜0.05). Compared with the control group, the AIH group had significantly higher levels of IFN-γ and CXCL10 and mRNA expression of TLR4 (t=6.949, 12.303, and 13.835, all P＜0.05). The correlation analysis showed that in the children with AIH, the expression of miR-181c in PBMCs was negatively correlated with IFN-γ, CXCL10, TLR4, AST, ALT, GGT, TBil, and IgG (r=-0.316, -0.348, -0.322, -0.427, -0.442, -0.408, -0.396, and -0.321, all P＜0.05). The univariate logistic regression analysis showed that AST, ALT, GGT, TBil, IFN-γ, CXCL10, TLR4 mRNA, and miR-181c were all included in the regression model (all P＜0.05) and were the influencing factors for the onset of AIH. ConclusionChildren with AIH have downregulated expression of miR-181c in PBMCs, which is closely associated with IFN-γ, CXCL10, and TLR4, suggesting that miR-181c may affect the development of AIH in children by regulating the immune system.

OBJECTIVE: Considering the different prevalence rates of diseases such as asthma and chronic obstructive pulmonary disease in Asians relative to other races, Koreans may have unique airway structure and lung function. This study aimed to investigate unique features of airway structure and lung function based on quantitative computed tomography (QCT)-imaging metrics in the Korean Asian population (Koreans) as compared with the White American population (Whites). MATERIALS AND METHODS: QCT data of healthy non-smokers (223 Koreans vs. 70 Whites) were collected, including QCT structural variables of wall thickness (WT) and hydraulic diameter (Dh) and functional variables of air volume, total air volume change in the lung (ΔVair), percent emphysema-like lung (Emph%), and percent functional small airway disease-like lung (fSAD%). Mann-Whitney U tests were performed to compare the two groups. RESULTS: As compared with Whites, Koreans had smaller volume at inspiration, ΔVair between inspiration and expiration (p < 0.001), and Emph% at inspiration (p < 0.001). Especially, Korean females had a decrease of ΔVair in the lower lobes (p < 0.001), associated with fSAD% at the lower lobes (p < 0.05). In addition, Koreans had smaller Dh and WT of the trachea (both, p < 0.05), correlated with the forced expiratory volume in 1 second (R = 0.49, 0.39; all p < 0.001) and forced vital capacity (R = 0.55, 0.45; all p < 0.001). CONCLUSION: Koreans had unique features of airway structure and lung function as compared with Whites, and the difference was clearer in female individuals. Discriminating structural and functional features between Koreans and Whites enables exploration of inter-racial differences of pulmonary disease in terms of severity, distribution, and phenotype.
Asian Continental Ancestry Group ; Asthma ; Continental Population Groups ; Female ; Forced Expiratory Volume ; Humans ; Lung ; Lung Diseases ; Phenotype ; Prevalence ; Pulmonary Disease, Chronic Obstructive ; Thorax ; Trachea ; Vital Capacity

Objective To explore the influence of the health management among coronary heart disease (CHD) patients after stent implementation. Methods A total of 32 CHD patients with postoperative stent implementation were randomly divided into experimental group ( received 6 months health management) and control group on (received routine discharge education) average and the results of education in two groups were compared and analyzed. Results After 6 months, there were (125. 9 ± 14. 9) mmHg, (72. 8 ± 8. 4) mmHg, (5. 44 ± 0. 53)mmol/ L, (3. 79 ± 1. 11) mmol/ L, (25. 4 ± 12. 4) U/ L, (63. 8 ± 7. 6) scores in systolic pressure, diastolic pressure, fasting blood-glucose, blood fat, liver function and body quality assessment in the experimental group compared with (133. 8 ± 11. 6) mmHg, (79. 4 ± 8. 3) mmHg, (7. 46 ± 2. 98) mmol/ L, (5. 22 ± 1. 33) mmol/ L, (38. 7 ± 13. 7)U/ L, (65. 8 ± 13. 3) scores in the control group (t = 2. 186, 2. 223, 2. 635, 2. 361, 1. 972, 2. 336,respectively;P < 0. 05). Conclusions After CHD patients acquired stent implementation, the health management can effectively minimize or stabilize the indexes of patient′ s blood pressure, blood glucose, blood fat, liver function and body quality, decrease recurrence of CHD, and promote the quality of life among CHD patients after stent implementation.

OBJECTIVETo study the relationship between the genetic diversity and chemical variation of Cinnamomum migao.

METHODISSR marker technique was used to research the genetic structure of 9 population, GC-MS was used to analyze the main ingredients of the volatile oil in C. migao.

RESULTThe analysis on the main ingredients of the volatile oil showed that there were significant or extremely significant differences in 9 populations. The minimum variation index of population was Yunnan Funing and the maximum variation index of population was Guangxi Yueye. ISSR marker analysis showed that the average of polymorphic loci percentage (P) was 42.41%, expected heterozygosity (H) was 0.181 0, Shannon's information index (I) was 0.293 8, the Nei's genetic diversity (H(s)) in the group was 0.188 9, genetic differentiation index (G(st)) was 2.269 1. The relationship between the genetic diversity and chemical variation showed that there was no significant correlation between the main ingredients of the volatile oil and 4 indexes of genetic structure of C. migao.

CONCLUSIONThe genetic diversity of C. migao was relatively high at the population levels, while it is low within the population levels, the relationship between chemical variation and genetic diversity was not obvious, that may indicate that other factors causes the chemical variation of C. migao.

China ; Cinnamomum ; chemistry ; genetics ; DNA ; genetics ; isolation & purification ; Gas Chromatography-Mass Spectrometry ; Genetic Markers ; Genetic Variation ; genetics ; Oils, Volatile ; analysis ; chemistry ; isolation & purification ; Plant Oils ; chemistry ; Polymorphism, Genetic ; genetics ; Repetitive Sequences, Nucleic Acid ; genetics

OBJECTIVETo study the biomass structure of Epimedium acuminatum Franch in the different ecological environments for the development and protection.

METHODThrough the scientific investigation in four typical habitats, the sampling spots were set up, the functional modules' biomass structure and relationship of E. acuminatum were researched.

RESULTThe average of rhizome, as the largest biomass, and the average total biomass had the same pattern: the open areas of forest edge > shrub lumber > shrub-weed > stream drains. The ratio of the functional modules' biomass had different rates under different habitat conditions. By analyzing and combining investigation, the aerial part of E. acuminatum in the shrub-weed were comparative advantage, and the roots of nutrient accumulation of E. acuminatum in the open areas of forest edge were the highest efficient. Under different ecological condition, the distribution of water metabolism was different strategies.

CONCLUSIONIn the open areas of forest edge, E. acuminatum growing well, followed by shrub-weed. These two habitats are the ideal ecological environments while the rhizome or the whole plant used as medicine, but also the protection of E. acuminatum.

Biomass ; Ecosystem ; Epimedium ; growth & development