Objective To investigate the effect of compound Xueshuantong combined with viaminate of oral lichen planus(OLP)complicated with chronic periodontitis(CP).Methods This study collected 305 patients with OLP and CP and randomly divided them into two groups.There were 156 patients in the observation group and 149 patients in the control group.All patients receive systemic treatment for CP.The control group was treated with viaminate capsules,and the observation group was treated with compound Xueshuantong Capsules combined with viaminate capsules.Both groups were treated for 4 weeks.Clinical efficacy,serum inflammatory factors[matrix metalloproteinase-3(MMP-3),IFN-gamma(IFN-γ),interleukin 6(IL-6)and IL-35],oral mucosal pain Visual Analogue Score(VAS),lesion area of OLP,periodontal condition,and adverse reactions were detected.Results Compared to the control group,the total effective rate in the observation group was higher(P<0.05).After treat-ment,serum MMP-3 and IL-6 levels,oral mucosal VAS score,lesion area of OLP,gingival index and probing depth all decreased in the two groups(P<0.05).The changes of above indicators were more significant in the observation group(P<0.05).There was no difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Compound Xueshuantong combined with viaminate can effectively improve the symptoms of OLP complicated with CP,and alleviate inflammatory reactions,with good therapeutic effects.