Objective To investigate the clinical characteristics of new and serious adverse drug reactions(ADRs)and provide a basis for safe medication use.Methods A retrospective analysis was conducted on 279 cases of new and serious ADRs reported at Guangzhou Chest Hospital from 2020 to 2024.Data on the type of ADR report,organs/systems involved,patient age and gender,categories of drugs involved,and dosage forms were collected for characteristic and pattern analysis.Results The majority of cases were serious ADRs(63.8％),with a higher proportion in males(57.3％,male-to-female ratio=1.34∶1).Patients aged 45 years and above accounted for 63.1％of cases.The ADRs involved 96 drugs from 12 categories,with anti-infec-tive drugs accounting for 75.0％.Oral administration(65.1％)and intravenous infusion(32.6％)were the main routes of ad-ministration.Digestive system damage was the most common(39.1％),followed by skin and appendage damage(12.3％),he-matologic system damage(10.5％),and nervous system damage(9.6％).Conclusion The occurrence of ADRs is associated with multiple factors such as age and route of administration.There is a need to strengthen multidisciplinary collaboration,en-hance medication monitoring and ADR surveillance in clinical practice to ensure medication safety.

Objective To investigate the clinical characteristics of new and serious adverse drug reactions(ADRs)and provide a basis for safe medication use.Methods A retrospective analysis was conducted on 279 cases of new and serious ADRs reported at Guangzhou Chest Hospital from 2020 to 2024.Data on the type of ADR report,organs/systems involved,patient age and gender,categories of drugs involved,and dosage forms were collected for characteristic and pattern analysis.Results The majority of cases were serious ADRs(63.8％),with a higher proportion in males(57.3％,male-to-female ratio=1.34∶1).Patients aged 45 years and above accounted for 63.1％of cases.The ADRs involved 96 drugs from 12 categories,with anti-infec-tive drugs accounting for 75.0％.Oral administration(65.1％)and intravenous infusion(32.6％)were the main routes of ad-ministration.Digestive system damage was the most common(39.1％),followed by skin and appendage damage(12.3％),he-matologic system damage(10.5％),and nervous system damage(9.6％).Conclusion The occurrence of ADRs is associated with multiple factors such as age and route of administration.There is a need to strengthen multidisciplinary collaboration,en-hance medication monitoring and ADR surveillance in clinical practice to ensure medication safety.

Purpose To investigate the expression of SNRPA in gastric cancer and its effect on the proliferation,migration and invasion of gastric cancer cells.Methods The expression of SNRPA in gastric cancer tissues was ana-lyzed using The Cancer Genome Atlas(TCGA)database.The level of SNRPA was detected by immunohistochemistry(EnVision method),and its relationship with clinicopathological parameters was analyzed.Western blot was used to detect the expression of SNRPA in 15 cases of fresh gastric cancer and paracancerous tissues.The expression of SNRPA in MGC-803 and GES-1 cells was detected by immunofluorescence staining.The effects of SNRPA expression on the proliferation,migration and invasion of gastric cancer cell lines were determined by RNA interference technology and cell function assays,and the expression levels of Cyclin D1 protein and EMT-related proteins(E-cadherin,N-cadher-in)were detected by Western blot.Results The expression level of SNRPA in gastric cancer tissues was significantly higher than that in normal gastric mucosal tissues(P＜0.05),with an area under the curve(AUC)of 0.902 for diag-nostic accuracy.The Kaplan-Meier survival curves showed that the survival time of the group with high expression of SNRPA was shorter.SNRPA expression correlated with tumor size,Ki67,infiltration depth,and p53 status(P＜0.05).Compared with the corresponding control group,SNRPA silencing inhibited the proliferation,migration and in-vasion ability of gastric cancer cells,accompanied by decreased Cyclin D1 and N-cadherin expression and increased E-cadherin expression(P＜0.05).Conclusion SNRPA expression is upregulated in gastric cancer tissues and cell lines,promoting the proliferation,migration,and invasion of gastric cancer cells,and may be a potential molecular marker for gastric cancer.

Purpose To investigate the expression of SNRPA in gastric cancer and its effect on the proliferation,migration and invasion of gastric cancer cells.Methods The expression of SNRPA in gastric cancer tissues was ana-lyzed using The Cancer Genome Atlas(TCGA)database.The level of SNRPA was detected by immunohistochemistry(EnVision method),and its relationship with clinicopathological parameters was analyzed.Western blot was used to detect the expression of SNRPA in 15 cases of fresh gastric cancer and paracancerous tissues.The expression of SNRPA in MGC-803 and GES-1 cells was detected by immunofluorescence staining.The effects of SNRPA expression on the proliferation,migration and invasion of gastric cancer cell lines were determined by RNA interference technology and cell function assays,and the expression levels of Cyclin D1 protein and EMT-related proteins(E-cadherin,N-cadher-in)were detected by Western blot.Results The expression level of SNRPA in gastric cancer tissues was significantly higher than that in normal gastric mucosal tissues(P＜0.05),with an area under the curve(AUC)of 0.902 for diag-nostic accuracy.The Kaplan-Meier survival curves showed that the survival time of the group with high expression of SNRPA was shorter.SNRPA expression correlated with tumor size,Ki67,infiltration depth,and p53 status(P＜0.05).Compared with the corresponding control group,SNRPA silencing inhibited the proliferation,migration and in-vasion ability of gastric cancer cells,accompanied by decreased Cyclin D1 and N-cadherin expression and increased E-cadherin expression(P＜0.05).Conclusion SNRPA expression is upregulated in gastric cancer tissues and cell lines,promoting the proliferation,migration,and invasion of gastric cancer cells,and may be a potential molecular marker for gastric cancer.

Objective The aim is to provide drug regimen for patients who have hormone allergy history but need hor-mone therapy.Methods Pharmacists analyzed the sensitization mechanism of methylprednone in combination with insturction and literature,assisted clinicians to formulate oral hormone therapy for tuberculosis meningitis with history of menthylprednisolone and verified the effectiveness and safety of the drug regimen.Results Methylprednisolone injection contains trace amount of milk protein and should not be used in patients with definite allergy to cow's milk.After changing to oral hormone therapy,the patient did not appear allergic again,and the condition was stable.Conclusion Gucocorticoids can also induce allergic reactions,so patients'previous allergic history should be paid attention in the process of medical history collection.Meanwhile,pharmacists can also give full play to their pharmaceutical expertise to assist clinicians in formulating individualized drug administration plans to ensure the effectiveness and safety of patients.

Objective:The study aimed to investigate the clinical efficacy of integrated trilobal method for composite reduction labiaplasty.Methods:This study was a single-center, retrospective and observational study. The clinical data of patients diagnosed with hypertrophy of the labia minora and clitoral hood who underwent trilobal labiaplasty at the Plastic Surgery Hospital, Chinese Academy of Medical Sciences from April 2019 to January 2024 were retrospectively analyzed. In this technique, three flaps were designed at the junction of the clitoral hood and labia minora (M flap), as well as the medial (I flap) and lateral surfaces (E flap) of the labia minora. The goal was to preserve the clitoral-labial triangle while selecting and retaining tissues with optimal texture and color for reshaping the clitoral hood and labia minora. Patients were followed up 7-10 days and 3 months post-surgery, during which pre- and postoperative appearance comparisons, symptom improvement, complications and satisfaction questionnaires. At 3 months post-surgery, the patients completed the female genital self-image scale (FGSIS) score, which has a total score range of 7-28 points, with higher score indicating a more positive genital self-image. A total score of ≥21 points indicated satisfaction with the surgical outcome. SPSS 29.0 software was used to analyze the data. Age and operation time were reported as Mean ± SD. Preoperative and postoperative FGSIS scores were described as M ( Q1, Q3) and compared using the Wilcoxon Signed Rank test. Statistical significance was set at P<0.05. Results:A total of 556 patients were enrolled in this study, aged 18-53 years, with a mean age of (29.3±7.7) years. The primary concerns included poor aesthetic appearance, pain or discomfort, difficulty in cleaning, urinary deviation, and sexual discomfort. The procedure was performed smoothly with minimal bleeding. Small hematomas (≤2 cm 2) developed in the M flap in 8 cases within 24 hours post-procedure. Two patients returned to the hospital for hematoma removal, while 6 patients did not require additional treatment, which did not affect the healing of the incision. Postoperative wound dehiscence was observed in 2 cases at the junction of three flaps. However, the dehiscence was short (0.3-0.8 cm) and superficial, with no reports of secondary infection or poor wound healing. A total of 540 patients (97.12%) were followed up for 3 months, and no serious complications or deformities were reported. Six patients (1.11%) underwent a secondary repair surgery due to bilateral incomplete symmetry. The FGSIS score for the 540 patients was 26 (23, 27) points at 3 months post-operation, significantly higher than the preoperative score of 14 (9, 15) points before the operation ( Z=-20.38, P<0.001). Among these, 506 patients (93.70%) achieved FGSIS scores of ≥21 points, indicating satisfaction with both the cosmetic results and functional improvements. Conclusion:The trilobal method, featuring an integrated design for composite reduction labiaplasty, effectively removes redundant tissue in both the horizontal and vertical directions of the labia minora. Additionally, it addresses the lateral folds of the clitoral hood, resulting in fewer complications and high levels of postoperative functional and aesthetic satisfaction.

Objective:The study aimed to investigate the clinical efficacy of integrated trilobal method for composite reduction labiaplasty.Methods:This study was a single-center, retrospective and observational study. The clinical data of patients diagnosed with hypertrophy of the labia minora and clitoral hood who underwent trilobal labiaplasty at the Plastic Surgery Hospital, Chinese Academy of Medical Sciences from April 2019 to January 2024 were retrospectively analyzed. In this technique, three flaps were designed at the junction of the clitoral hood and labia minora (M flap), as well as the medial (I flap) and lateral surfaces (E flap) of the labia minora. The goal was to preserve the clitoral-labial triangle while selecting and retaining tissues with optimal texture and color for reshaping the clitoral hood and labia minora. Patients were followed up 7-10 days and 3 months post-surgery, during which pre- and postoperative appearance comparisons, symptom improvement, complications and satisfaction questionnaires. At 3 months post-surgery, the patients completed the female genital self-image scale (FGSIS) score, which has a total score range of 7-28 points, with higher score indicating a more positive genital self-image. A total score of ≥21 points indicated satisfaction with the surgical outcome. SPSS 29.0 software was used to analyze the data. Age and operation time were reported as Mean ± SD. Preoperative and postoperative FGSIS scores were described as M ( Q1, Q3) and compared using the Wilcoxon Signed Rank test. Statistical significance was set at P<0.05. Results:A total of 556 patients were enrolled in this study, aged 18-53 years, with a mean age of (29.3±7.7) years. The primary concerns included poor aesthetic appearance, pain or discomfort, difficulty in cleaning, urinary deviation, and sexual discomfort. The procedure was performed smoothly with minimal bleeding. Small hematomas (≤2 cm 2) developed in the M flap in 8 cases within 24 hours post-procedure. Two patients returned to the hospital for hematoma removal, while 6 patients did not require additional treatment, which did not affect the healing of the incision. Postoperative wound dehiscence was observed in 2 cases at the junction of three flaps. However, the dehiscence was short (0.3-0.8 cm) and superficial, with no reports of secondary infection or poor wound healing. A total of 540 patients (97.12%) were followed up for 3 months, and no serious complications or deformities were reported. Six patients (1.11%) underwent a secondary repair surgery due to bilateral incomplete symmetry. The FGSIS score for the 540 patients was 26 (23, 27) points at 3 months post-operation, significantly higher than the preoperative score of 14 (9, 15) points before the operation ( Z=-20.38, P<0.001). Among these, 506 patients (93.70%) achieved FGSIS scores of ≥21 points, indicating satisfaction with both the cosmetic results and functional improvements. Conclusion:The trilobal method, featuring an integrated design for composite reduction labiaplasty, effectively removes redundant tissue in both the horizontal and vertical directions of the labia minora. Additionally, it addresses the lateral folds of the clitoral hood, resulting in fewer complications and high levels of postoperative functional and aesthetic satisfaction.

Labia minora resection is one of the key method to solve labia minora hypertrophy. And it is reported that wedge resection is becoming a research hotspot as a common method. By a comprehensive literature search, the purpose of this article is to study and analyze the improvement of wedge resection in the treatment of labia minora hypertrophy over the past few years. At the same time, the characteristics, complications, and postoperative outcomes of the different resection method will be discussed based on the previous data. It is concluded that wedge resection has achieved positive treatment effects in the therapy of labia minora hypertrophy.

Phalloplasty can be considered as a important way to reconstruct erectile function for female-to-male transsexuals, patients with penile defect or genital malformations. Meanwhile, penile prostheses, such as autologous tissue, artificial prosthesis and other tissues, play a key role in reconstructing erectile function. Thus, the purpose of this article is to analyze relevant research reports in recent years, since research goes deeper and improvements have been achieved in this field.

Phalloplasty can be considered as an important way to reconstruct erectile function for female-to-male transsexuals, patients with penile defect or genital malformations. Meanwhile, various types of penile supports such as autologous tissue, artificial prosthesis and other tissues, play a key role in reconstructing erectile function. The purpose of this article is to analyze relevant research reports in recent years, since research goes deeper and improvements have been achieved in this field.