Patients with pancreatic cancer have low survival rates, largely because patients are diagnosed at an advanced stage. Current strategies for early detection, including imaging, blood tests, and genetic sequencing, have limited performance. Recent advances in artificial intelligence (AI) have shown that AI models can identify subtle pre-diagnostic imaging changes that may not be visible to radiologists, raising the possibility of earlier and more consistent pancreatic cancer detection. Despite this progress, real-world implementation of AI for pancreatic cancer detection remains limited. Most models struggle with reproducibility and generalizability across different institutions. Few have undergone prospective validation, and practical issues such as workflow integration, financial constraints, and continuous model monitoring remain unresolved. This article reviews the current state of AI for pancreatic cancer detection and outlines barriers beyond model specifics that must be addressed to enable clinical translation.

Appendicitis or Not Appendicitis: A Case Report of Acute Appendicitis Complicated with Disseminated MSSA and Iliopsoas Abscess This case report describes a 17-year-old female with acute appendicitis complicated by Methicillin-Sensitive Staphylococcus Aureus (MSSA) bacteremia and an iliopsoas abscess. Initially presenting with right iliac fossa pain and fever, she was diagnosed with acute appendicitis and underwent appendectomy. Postoperatively, she developed persistent fever and hip pain. Imaging revealed an abscess in the right iliacus muscle, which was drained percutaneously. MSSA was identified in the abscess culture. The patient recovered with targeted antibiotics. This case highlights the diagnostic challenges and importance of considering secondary infections in postoperative patients with atypical symptoms. Prompt recognition and treatment are essential for positive outcomes.

This case report illustrates two cases of complete androgen insensitivity syndrome (CAIS) which is a rare form of sexual development disorder. Both presented with primary amenorrhea at the age of 18 and 19 years old. The hormonal profiles ruled out hypothyroidism, hyperprolactinemia, and primary ovarian failure. Magnetic resonance imaging of both patients showed the absence of uterus, fallopian tubes, ovaries, but the presence of proximal 1/3rd of the vagina. There is a single testis in the left inguinal region with unknown status of spermatogenesis. Women with CAIS are vulnerable to various psychological conditions caused by the appalling fact of being genotypically male when they have been raised female all their life. The gender confusion, reproductive issues, and how others perceive them require sensitive support. Hence, accentuate the need to explore and address the emotional, psychological, and psychiatric vulnerabilities, religious and spiritual beliefs in issues of relationships, infertility, and conception.

In this study we examined the suitability of the-imidazo[4,5-]pyridine ring system in developing novel anticancer and anti-inflammatory agents incorporating a diaryl pharmacophore. Eight 2,3-diaryl-3-imidazo[4,5-]pyridine derivatives retrieved from our in-house database were evaluated for their cytotoxic activity against nine cancer cell lines. The results indicated that the compounds showed moderate cytotoxic activity against MCF-7, MDA-MB-468, K562 and SaOS2 cells, with K562 being the most sensitive among the four cancer cell lines. The eight 2,3-diaryl-3-imidazo[4,5-]pyridine derivatives were also evaluated for their COX-1 and COX-2 inhibitory activity. The results showed that compoundexhibited 2-fold selectivity with ICvalues of 9.2 and 21.8 µmol/L against COX-2 and COX-1, respectively. Molecular docking studies on the most active compoundrevealed a binding mode similar to that of celecoxib in the active site of the COX-2 enzyme.

Background: Aptamers are single-stranded nucleic acids, so-called ‘artificial antibodies’, identified from the randomized combinatorial library against the target by the process called ‘SELEX’ (Systematic Evolution of Ligands by EXponential enrichment). Target can have any sizes from small molecules to the whole cell, attests the versatility of aptamers to bind a wide range of targets. Aptamers have several advantages over antibodies, such as they are easy to prepare, cheaper, have no batch variations, are easy to modify, stable and most importantly, non-immunogenic. Because of these positive characteristics, aptamers are incorporated in different fields, and most attractive in the applications involving therapeutics and diagnoses (theranostics). With either aptamers alone or complementing with antibodies, several high sensitive, portable sensors have been demonstrated for use in ‘bedside analysis’. Moreover, aptamers are more amenable to chemical modifications, making them capable of utilization with the most developed aptasensors (aptamerbased sensors). Significance: The development of more sensitive aptasensors could be useful and important for medical diagnosis, identification of pathogens for the quality control of consumable items, and surveillance of emerging diseases. In fact, aptasensors have already shown their efficacy in the detection of life threatening diseases caused by early stage of viral infections. In this review, role of aptasensors in detecting pathogenic viruses are overviewed. Keywords: Anti-virus; aptamer; aptasensor; bedside analysis; SELEX

Objective To summarize the precise association between pulmonary tuberculosis (PTB) and P2x7 A1513C gene polymorphism. Methods PubMed and Google Scholar web-databases were searched for the studies reporting the association of P2x7 A1513C polymorphism and PTB risk. A meta-analysis was performed for the selected case–control studies and pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for all the genetic models. Results Eleven studies comprising 2 678 controls and 2 113 PTB cases were included in this meta-analysis. We observed overall no significant risk in all the five genetic models. When stratified population by the ethnicity, Caucasian population failed to show any risk of PTB in all the genetics models. In Asian ethnicity, variant allele (C vs. A: P = 0.001; OR = 1.375, 95% CI = 1.159–1.632) and heterozygous genotype (AC vs. AA: P = 0.001; OR = 1.570, 95% CI = 1.269–1.944) demonstrated significant increased risk of PTB. Likewise, recessive genetic model (CC + AC vs. AA: P = 0.001; OR = 1.540, 95% CI = 1.255–1.890) also demonstrated increased risk of PTB in Asians. Conclusions Our meta-analysis did not suggest the association of P2x7 A1513C polymorphism with PTB risk in overall or separately in Caucasian population. However, it plays a significant risk factor for predisposing PTB in Asians. Future larger sample and expression studies are needed to validate this association.

Hartmannella sp is one of the free-living amoebae that have the ability to infect animal tissues because it has been found in human's nasal mucosa, dog's bronchial and turkey's intestine. Treatment for diseases inflicted by free-living amoebae is difficult because most of them infect and damage the host's tissues, so preventive measures are better to take rather than to cure the diseases. In this study, water taken from several stations namely Kampung Padang, Kampung Besut, Ibu Bekalan Setiu, Kampung Tasik, Kampung Guntung, Kampung Nyatoh, Kampung Penarik and Kampung Mangkok) along Sungai Setiu, Terengganu was examined for the presence of Hartmannella sp. The results of this study indicated that only Ibu Bekalan Setiu station was found positive to have the amoeba. Detail results on the water quality and nutrient contents measured in relation to the distribution of the amoeba at Ibu Bekalan Setiu station are presented and discussed.
g <3> ; seconds ; livin ; Hartmannella ; Ibu