[Objective]To investigate the prevalence of high-risk HPV infection among women in Kashgar area,analyze related risk factors,conduct follow-up and health education interventions for positive cases in the past three years,and assess intervention outcomes to improve HPV screening awareness and reduce cervical cancer incidence.[Methods]This study randomly selected 571 women from Kashgar who underwent HPV screening as part of a health check-up in the First People's Hospital of Kashgar between January 2021 and June 2023.High-risk HPV-DNA was detected using the PCR-RDB method.Based on the test results,participants were divided into HPV-negative and HPV-positive groups,and the infection rates and associated risk factors were analyzed.Additionally,follow-up was conducted for women who tested positive for high-risk HPV during the screening to assess the effectiveness of health management interventions.[Results]From 2021 to 2023,the high-risk HPV positive rate among women in Kashgar showed a year-on-year decline,recorded at 19.15%,16.43%,and 11.30%,respectively(P<0.001),with a total of 3,921 cases(16.13%)testing positive for high-risk HPV during this period.Uyghur women had a significantly higher infection rate compared with those of Han nationality and other ethnic minorities(P<0.05).Risk factors included age,age at first sexual activity,number of sexual partners,contraceptive methods,and a history of vaginal inflammation(P<0.05).Health management interventions significantly improved participants'awareness scores regarding cervical cancer prevention and the proportion of women voluntarily receiving HPV vaccination(P<0.05).[Conclusions]High-risk HPV infection among Uyghur women in Kashgar area is relatively high,with single infection of HPV-16 and HPV-52 and mixed infections of HPV-16+HPV-52 and HPV-16+HPV-58 being predominant.Risk factors include age at first sexual activity,number of sexual partners,contraceptive methods,and history of vaginal inflammation.Through triple-education interventions,the incidence of cervical cancer in Kashgar has been effectively reduced,and standards for primary-level diagnosis,treatment,and health supervision have been improved.