BACKGROUND: Our previous observational cohort study, the Kashima Scan Study (KSS), identified associations between lifestyle, cerebral small vessel disease (SVD) as detected by magnetic resonance imaging of the brain, and disease outcomes including cognitive impairment and vascular diseases. However, established modifiers of the outcomes such as genetic background, drinking and exercise habits, and socioeconomic status were not considered. Regarding genetic factors in particular, the ALDH2 rs671 variant, East Asian-specific diversity, and APOE status are expected to have strong effects. The aim of KSS-2 is to examine the interactions of genetic background, lifestyle factors including drinking habit, socioeconomic status, and/or SVD markers for cognitive impairment, vascular disease, and death. METHOD: The KSS-2 is a prospective regional observational study of a healthy Japanese cohort that will clarify lifestyle habits to better maintain brain health from midlife by genotype. Japanese adults who underwent brain health checkups at their own expense are enrolled and will be followed-up for 10 years. We will extend the protocol of the KSS to include genetic background and potential confounding factors, including lifestyle (including drinking and exercise habit) and socioeconomic status, and perform survival analyses. The study outcomes are cognitive impairment, vascular events, and death. RESULTS: We enrolled 908 healthy adults (mean age 64.2 years; range 35 to 84 years; 41% male) from September 1, 2018 until December 31, 2024. CONCLUSION This study will provide important insights into the development of individualized health intervention strategies.
Adult ; Aged ; Aged, 80 and over ; Female ; Humans ; Male ; Middle Aged ; Cerebral Small Vessel Diseases/diagnostic imaging* ; Japan/epidemiology* ; Life Style ; Magnetic Resonance Imaging ; Prospective Studies ; Observational Studies as Topic

Purpose
An organism receives internal and external stimuli successively. If the function of the organism become abnormal, the abnormality is projected on its body surface. Accordingly the condition of the organism's function can be grasped by palpation or other objective measuring methods.
Among these methods, we commonly put skin-electroresistance meters in clinical use.
However, the variation of the organism's function in a healthy condition has not been quantitatively grasped, while there are data on the variation of the values obtained from sick patients.
The purpose of this study is to investigate the variation of values obtained from subjects in a healthy condition in order to grasp the abnormal variation of values more exactly.
Method
Subjects were sixth-year pupils of Osaka Municial Elementary School of Higashi Awaji. Neurometory was sutomatically recorded at the regular points 0.75 second after the onset of the measurement, with a neurometer (Improved Model D-401; Noiro Ika Kogyo Inc.) adjusted at 12V, 200mV.
Result
Excited H₆ large intestine channels, and inhibited F₂ liver channels and F₆ stomach channels were frequently seen as in the same time of other years.
Unlike adult subjects, the current intensity was low in the Yong meridians of the hand (H4, 5, 6), and high in the Yin meridians of the hand and the foot (H1, 2, 3, F1, 2, 3).