1.Screening and management of bladder and bowel dysfunction among toilet trained children in a general pediatric outpatient clinic of a Tertiary Hospital using standard urotherapy: Prospective interventional study.
Melanie O. UY MATIAO ; Maria Rosario F. CABANSAG ; Remedios D. CHAN ; Maria Margarita M. ROMANO ; Jemely M. PUNZALAN ; Dennis FLORES ; David C T. BOLONG
Journal of Medicine University of Santo Tomas 2026;10(1):1862-1872
OBJECTIVES
This study determined the prevalence of BBD among toilet-trained children attending a tertiary hospital’s pediatric outpatient clinic, and to evaluate the effectiveness of standard urotherapy among affected children.
METHODSA prospective interventional study was conducted among 144 toilet-trained children aged 7 to 12 years seen at the University of Santo Tomas Hospital outpatient clinic from August 2025 to September 2025. Sociodemographic data were collected, and BBD was screened using the validated Filipino version of the Dysfunctional Voiding Symptom Scores (DVSS) questionnaire. Children with BBD underwent standard urotherapy, which included behavioral and lifestyle interventions such as timed voiding, adequate hydration, constipation management and proper voiding posture. DVSS assessments were repeated at two and four weeks.
RESULTSThe overall prevalence of BBD was 22.9% (33 of 144). BBD was significantly more prevalent among females (31.88%) than males (14.67%) (adjusted OR = 2.96, 95% CI: 1.28–6.86; p = 0.011). At baseline, children with BBD had significantly higher mean total DVSS scores (9.15 ± 3.64) compared to those without (2.01 ± 1.80, pCONCLUSION
Standard urotherapy proved effective in reducing symptom scores within two weeks and resulted in complete clinical resolution after four weeks among those who continued therapy. Routine screenings for BBD using DVSS and early initiation of standard urotherapy in pediatric outpatient settings are recommended to prevent complications and improve children’s urinary and bowel health.
Human ; Child: 6-12 Yrs Old ; World Health Organization ; Outpatient Clinics, Hospital ; Mass Screening ; Tertiary Care Centers ; Constipation ; Ambulatory Care Facilities
2.Translation and validation of the Filipino version of the knowledge, attitudes and practices questionnaire on personal antibiotic use (KAPQ-PAU-FIL): Potential utility in public health programs in the Philippines.
Maxine Francesco Gwyneth C. BACULO ; Samantha Nicole L. BABAO ; Francesca Anne I. BANDARLIPE ; Fitz Cornelius I. BANEZ ; Evelyn SIAO-BRIGINO ; Wennielyn F. FAJILAN ; Roberto D. AMPIL ; Marvin M. ZAPICO ; Maria Rosario R. ARANDA ; Rosalyn G. MIRASOL ; Ivan Neil B. GOMEZ
Journal of Medicine University of Santo Tomas 2026;10(1):1883-1894
INRODUCTION
The growing misuse of antibiotics and the escalating threat of antibiotic resistance in the Philippines pose significant public health concerns. While various Knowledge, Attitudes and Practices (KAP) questionnaires on personal antibiotic use have been employed in local studies, none have been fully validated and a standardized, culturally appropriate tool remains lacking.
OBJECTIVEThis study aims to develop a Filipino-translated and culturally adapted KAP questionnaire on personal antibiotic use (KAPQ-PAU-FIL) and evaluate its validity and reliability.
METHODOLOGYThe research consisted of two phases. The first phase is the translation and cross-cultural adaptation of the original questionnaire in collaboration with the UST Sentro sa Salin at Araling Salin. The second phase is the validity and reliability testing of the KAPQ-PAU-FIL using a sample of 176 Filipino adults. This included assessment of its face validity, content validity, construct validity, internal consistency, test-retest reliability and equivalent forms reliability.
RESULTSMost items were translated without difficulty, though four items were modified to better fit the linguistic and cultural context. The KAPQ-PAU-FIL demonstrates strong psychometric properties, with face validity (SFVI/Ave = 0.99), content validity (SCVI/Ave = 0.99), construct validity (CFI = 0.92, RMSEA = 0.06, SRMR = 0.04; FL = 0.60-0.85; ITC = 0.58-0.71), test-retest reliability (ICC = 0.83), internal consistency (α = 0.929) and equivalent forms reliability (p>0.05; κ = 0.62-0.74).
CONCLUSIONThe KAPQ-PAU-FIL is the first ever, Filipino-translated, culturally adapted questionnaire designed to assess KAPQ-PAU-FIL, demonstrating strong validity and reliability to support public health programs against antibiotic misuse.
Surveys And Questionnaires ; Public Health ; Knowledge ; Anti-bacterial Agents ; Philippines ; Program
3.Emergent Carotid Stenting During Endovascular Therapy for Isolated Cervical Internal Carotid Artery Occlusion
Christoph RIEGLER ; João Pedro MARTO ; Pimrapat GEBERT ; Tilman REIFF ; Marek SYKORA ; Marcin WIĄCEK ; David PAKIZER ; André ARAÚJO ; Adrien ter SCHIPHORST ; João André SOUSA ; Arno REICH ; Belen Flores PINA ; Lukas MAYER-SUESS ; Cristina HOBEANU ; Marialuisa ZEDDE ; João Nuno RAMOS ; Georgios TSIVGOULIS ; Pedro CASTRO ; Sven POLI ; José Nuno ALVES ; Anne DUSART ; Blanca FUENTES ; Herbert Tejada MEZA ; Jelle DEMEESTERE ; Susanne WEGENER ; Lars KELLERT ; Patricia CALLEJA ; Cristina PANEA ; Christoph VOLLMUTH ; Liliana PEREIRA ; Ronen R. LEKER ; Timo UPHAUS ; Andrea ZINI ; Henrik GENSICKE ; Gauthier DULOQUIN ; Taraneh EBRAHIMI ; Alexander SALERNO ; Cristina TIU ; Thanh N. NGUYEN ; Sebastian GARCÍA-MADRONA ; Marta BILIK ; Shadi YAGHI ; Halina SIENKIEWICZ-JAROSZ ; Michał KARLIŃSKI ; Stefan KREBS ; Eva HURTÍKOVÁ ; Nathalia FERREIRA ; João SARGENTO-FREITAS ; João PINHO ; Isabel Rodriguez CAAMAÑO ; Elke Ruth GIZEWSKI ; Pierre SENERS ; Rosario PASCARELLA ; Klearchos PSYCHOGIOS ; Alexandra Gomez EXPOSITO ; Sara GOMES ; Flavio BELLANTE ; Jorge RODRÍGUEZ-PARDO ; Mario Bautista LACAMBRA ; Robin LEMMENS ; Corinne INAUEN ; Johannes WISCHMANN ; Fernando OSTOS ; Vlad TIU ; Karl Georg HAEUSLER ; Miguel RODRIGUES ; Issa METANIS ; Marianne HAHN ; Maria Maddalena VIOLA ; Simon TRUESSEL ; Yannick BEJOT ; Louisa NITSCH ; Davide STRAMBO ; Elena Oana TERECOASA ; Mohamad ABDALKADER ; Alicia De FELIPE ; Farhan KHAN ; Caroline ARQUIZAN ; Manuel RIBEIRO ; Martin ROUBEC ; Izabella TOMASZEWSKA-LAMPART ; Julia FERRARI ; Peter RINGLEB ; Christian H. NOLTE
Journal of Stroke 2026;28(1):160-171
Background:
and Purpose In patients with ischemic stroke and isolated cervical internal carotid artery occlusion (c-ICA-O), endovascular therapy (EVT) can improve cerebral perfusion. To maintain vessel patency, EVT is frequently combined with carotid artery stenting (CAS). We assessed the efficacy and safety of emergent CAS during EVT for isolated c-ICA-O.
Methods:
This retrospective multinational cohort study (42 centers) included consecutive patients who underwent EVT for isolated c-ICA-O within 24 hours from the time last seen well. Patients who underwent emergent CAS were compared with those who did not. Co-primary outcomes were c-ICA vessel patency and symptomatic intracerebral hemorrhage (sICH) 24 hours post-EVT. Secondary outcomes included any intracerebral hemorrhage (ICH) at 24 hours and disability at 3 months (modified Rankin Scale [mRS] shift). Outcomes were adjusted using inverse probability of treatment weighting.
Results:
Of 317 patients (mean age, 68.6 years [standard deviation, 12.9]; median National Institutes of Health Stroke Scale 11 [interquartile range, 6–17]; 26.8% female), 219 (69.1%) underwent CAS, whereas 98 (30.9%) did not. At 24 hours, vessel patency was more common after CAS (83.5% vs. 40.7%; adjusted odds ratio [aOR], 9.45; 95% confidence interval [CI], 4.91–18.17); sICH rates did not differ (2.3% vs. 3.1%; aOR, 0.92; 95% CI, 0.18–4.73). Any ICH was more common after CAS (19.3% vs. 9.3%; aOR, 2.50; 95% CI, 1.12–5.60). CAS was not associated with mRS at 3 months (adjusted common odds ratio, 0.98; 95% CI, 0.62–1.56).
Conclusions
In patients undergoing EVT for isolated c-ICA-O, emergent CAS was technically effective and reasonably safe. More frequent vessel patency in patients who underwent CAS did not translate into improved functional outcome at 3 months.
4.Safety of Endovascular Thrombectomy in Isolated Cervical Internal Carotid Artery Occlusion While on Oral Anticoagulation
Lukas MAYER-SUESS ; Christoph RIEGLER ; João Pedro MARTO ; Pimrapat GEBERT ; Tilman REIFF ; Marek SYKORA ; Marcin WIĄCEK ; David PAKIZER ; André ARAÚJO ; Adrien ter SCHIPHORST ; João André SOUSA ; Arno REICH ; Belen Flores PINA ; Cristina HOBEANU ; Marialuisa ZEDDE ; João Nuno RAMOS ; Georgios TSIVGOULIS ; Pedro CASTRO ; Sven POLI ; José Nuno ALVES ; Anne DUSART ; Blanca FUENTES ; Herbert Tejada MEZA ; Jelle DEMEESTERE ; Susanne WEGENER ; Lars KELLERT ; Patricia CALLEJA ; Cristina PANEA ; Christoph VOLLMUTH ; Karl Georg HAEUSLER ; Liliana PEREIRA ; Ronen LEKER ; Timo UPHAUS ; Andrea ZINI ; Henrik GENSICKE ; Gauthier DULOQUIN ; Taraneh EBRAHIMI ; Alexander SALERNO ; Cristina TIU ; Thanh N. NGUYEN ; Sebastian GARCÍA-MADRONA ; Marta BILIK ; Shadi YAGHI ; Halina SIENKIEWICZ-JAROSZ ; Michał KARLIŃSKI ; Stefan KREBS ; Eva HURTÍKOVÁ ; Nathalia FERREIRA ; João SARGENTO-FREITAS ; João PINHO ; Isabel Rodriguez CAAMAÑO ; Elke Ruth GIZEWSKI ; Pierre SENERS ; Rosario PASCARELLA ; Klearchos PSYCHOGIOS ; Alexandra GÓMEZ-EXPÓSITO ; Sara GOMES ; Flavio BELLANTE ; Jorge RODRÍGUEZ-PARDO ; Mario Bautista LACAMBRA ; Robin LEMMENS ; Corinne INAUEN ; Johannes WISCHMANN ; Fernando OSTOS ; Vlad TIU ; Miguel RODRIGUES ; Issa METANIS ; Marianne HAHN ; Maria Maddalena VIOLA ; Simon TRUESSEL ; Yannick BÉJOT ; Louisa NITSCH ; Davide STRAMBO ; Elena Oana TERECOASA ; Mohamad ABDALKADER ; Alicia De FELIPE ; Farhan KHAN ; Caroline ARQUIZAN ; Manuel RIBEIRO ; Martin ROUBEC ; Izabella TOMASZEWSKA-LAMPART ; Julia FERRARI ; Peter RINGLEB ; Christian H. NOLTE
Journal of Stroke 2026;28(2):321-325
5.Factors associated with preference for online learning modality among medical students of a private medical school in Quezon City, Philippines: An analytical cross-sectional study.
Christopher Angelo D. Domingo ; Malory Nicole R. Aluad ; Ymarleigh P. Andal, RMT ; Joshua Caesar M. Añ ; es ; Michelle Marie G. Angara ; Nicole D. Del Rosario ; Karen Hannah C. Deriquito ; Franzes Angienette S. Dizon, OTRP ; Rhinalyne Jashtine B. Dy Yaco, RPh ; Clarissa Angela A. Layusa, MD ; Maria Peñ ; afrancia L. Adversario, MD, MSPH
Health Sciences Journal 2026;15(1):16-22
Introduction:
The COVID-19 pandemic accelerated the adoption of alternative instructional approaches, including distance and online learning. This study aimed to determine factors associated with preference for online learning modality among medical students at a private medical school in the National Capital Region (NCR).
Methods:
An analytical cross-sectional study was conducted among 367 medical students using convenience sampling. Participants completed an online survey assessing preferred learning modality, general anxiety, self-efficacy, and satisfaction with online learning. Factors associated with preference for online learning were identified using logistic regression analysis.
Results:
Most respondents (79.3%) preferred traditional face-to-face learning, whereas 20.7% preferred online learning. Male students were more likely to prefer online learning than female students (OR = 2.19, p = 0.003). Married students were more likely to prefer online learning than unmarried students (OR = 9.71, p = 0.021). Students who reported greater satisfaction with their online learning experience were more likely to prefer online learning (OR = 2.28, p = 0.024). Self-efficacy demonstrated a borderline association with preference for online learning (OR = 0.42, p = 0.053).
Conclusion
Sex, civil status, and satisfaction with online learning were significantly associated with preference for online learning modality. Self-efficacy demonstrated a borderline association. Despite the increased use of online learning during the COVID-19 pandemic, most respondents continued to prefer traditional face-to-face instruction.
Education
;
Anxiety
;
Self-efficacy
6.A 4-year retrospective epidemilogical study of common dermatoses among pediatric from a tertiary referral center in Pangasinan
Celina Faye C. Manalastas ; Michelle D. Sim ; Maria Aurora Teresa H. Rosario
Journal of the Philippine Medical Association 2025;104(1):57-66
BACKGROUND
Pediatric dermatoses are multifactorial and diverse. Environmental factors play a significant role in skin disease. This study described the prevalence of common dermatoses among pediatric population seen at a tertiary referral center in Pangasinan.
METHODSThis was a 4-year retrospective, single center, chart review study in a tertiary referral hospital in Pangasinan. The researchers reviewed both electronic and medical charts of all pediatric outpatient and inpatient referrals with dermatoses from January 1, 2019 to December 31, 2022 by utilizing Proportion sampling technique.
RESULTSThis study reviewed a total of 501 (Males, 49.5% and Females, 50.5%) outpatient and inpatient pediatric patients who consulted due to skin related concerns. The majority of the patients were school-age children and adolescents followed by newborns, infants and toddlers respectively. Scabies infestation (n=76, 15.2%), Acne vulgaris (n=53, 10.6%) and Atopic dermatitis (n=48, 9.6%) were the top 3 common dermatoses among pediatric age groups. Scabies was the top diagnosis for both male (n=37, 14.9%) and female (n=39, 15.4%). Acne vulgaris (n=50, 31.6%) was the most common diagnosis in the adolescent age group.
CONCLUSIONThere was wide variation in the most common dermatosis according to age, sex, and year. Poor sanitation, overcrowding and low socioeconomic status are important factors for the increased prevalence of parasitic infestations. Acne vulgaris was seen almost exclusively in adolescents. This study served as a preliminary epidemiological report on pediatric dermatoses in Region 1 Medical Center that may pave the way for well-controlled and better designed researches in the future.
Human ; Epidemiologic Studies
7.A quasi-experimental study on the effectiveness of health education on the knowledge, attitude and practices about scabies among barangay health workers in Dagupan City
Stefanie Mae S. Belmes-Morales ; Gladys Maxima M. Rayos ; Maria Aurora Teresa H. Rosario ; May F. Gonzales
Journal of the Philippine Medical Association 2025;104(1):67-78
BACKGROUND
Scabies, recognized as one of the neglected tropical diseases (NTDs) by the WHO continues to persist in our locality today. Health education emerges as an indispensable tool, aimed at enhancing the knowledge, attitudes, and practices (KAP) of Barangay Health Workers (BHWs). As the primary frontliners in our community, they encounter a wide array of skin conditions, but often lack the resources to manage them effectively.
OBJECTIVESThe primary objective of this study is to assess the impact of health education on the KAP of BHWs concerning Scabies infestation.
METHODSA quasi-experimental, one-group pre-test-post-test design assessed the effectiveness of a 30-minute face-to-face lecture on BHWs’ KAP regarding Scabies infestation in the community. The study was conducted on April 25, 2023 at the Dagupan City Health office utilizing random population sampling.
RESULTSThe study included 45 BHW participants, 71.11% of whom had prior Scabies knowledge mainly from seminars/training (42.22%). Initially, most had poor baseline knowledge. Less than half (46.67%) identified skin manifestations and treatment accurately. Most displayed positive attitudes toward environmental management (91.11%) and fomite infection control (77.78%). After the lecture, the participants' total scores increased.
CONCLUSIONBHWs bridge the gap between healthcare and underserved populations. Equipping them with knowledge of diseases such as Scabies is imperative. This underscores the effectiveness of health education in enhancing their KAP towards Scabies. By empowering them, we can reduce the impact of NTDs in vulnerable communities. These findings have potential implications for future training programs, awareness campaigns, and further studies involving healthcare workers.
Human ; Scabies ; Health Education
8.Hemophagocytic lymphohistiocytosis: Clinical review at the Philippine Children’s Medical Center
Maria Beatriz P. Gepte ; Maria Luz O. del Rosario ; Eustacia M. Rigor
The Philippine Children’s Medical Center Journal 2025;21(2):151-162
BACKGROUND:
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by extreme immune activation, resulting in pathologic inflammation that may be life-threatening. Early recognition is crucial since survival largely depends on early initiation of treatment which utilizes a combination of chemotherapy, immunotherapy and in some cases even bone marrow transplantation.
OBJECTIVES:
This study aims to describe the clinical characteristics, treatment received and outcome of patients diagnosed with HLH at the Philippine Children’s Medical Center from 2004 to 2017.
MATERIALS AND METHODS:
A retrospective analysis of records of children 0-18 years of age diagnosed with HLH from January 2004 to December 2017 was done.
RESULTS:
A total of 39 patients were included in the study which gave an incidence of 1.22 per 3000 patients admitted under 18 years of age. There were 29 males (74.4%) and 10 females (25.6%) with a male to female ratio of 2.9:1 Mean age was 6.12 ± 3.89 years. The average time from initial presentation to diagnosis was 6 weeks and 2 days. The most commonly seen clinical and laboratory features observed in these patients were fever (100%), splenomegaly (71.8%), anemia (87.17%), thrombocytopenia (79.48%) and hypertriglyceridemia (69.23%). Only 5 patients were confirmed to be familial HLH with 3 having XLP gene mutation, and one each having syntaxin and perforin gene mutations. Majority of patients received a combination of treatment based on the HLH 2004 regimen while almost one third only received antibiotics. Only 23% of patients survived during the study period and all but one of these patients received drug combinations based on the HLH 2004 protocol.
CONCLUSIONS AND RECOMMENDATIONS
HLH is a rare but important condition that must be recognized early and treated appropriately to optimize
survival. The mortality rate of 39 patients seen in this institution is high. There is a need to better utilize the diagnostic criteria of the disease and to employ a more uniform treatment strategy. Increasing awareness among health care personnel can also improve case finding, characterization and treatment.
Human
;
Male
;
Female
;
Adolescent: 13-18 Yrs Old
;
Lymphohistiocytosis, Hemophagocytic
;
Philippines
9.Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment
João Pedro MARTO ; Davide STRAMBO ; George NTAIOS ; Thanh N NGUYEN ; Pawel WRONA ; Simon ESCALARD ; Simona MARCHESELLI ; Ossama Yassin MANSOUR ; Blanca FUENTES ; Malgorzata DOROBEK ; Marta NOWAKOWSKA-KOTAS ; Elena Oana TERECOASA ; Jonathan M. COUTINHO ; Mariana CARVALHO-DIAS ; Patricia CALLEJA ; João SARGENTO-FREITAS ; Ana PAIVA-NUNES ; Martin ŠRÁMEK ; Priyank KHANDELWAL ; Torcato MEIRA ; Mohamad ABDALKADER ; Pascal JABBOUR ; Martin KOVÁŘ ; Oscar AYO-MARTIN ; Patrik MICHEL ; Roman HERZIG ; Anna CZŁONKOWKSA ; Jelle DEMEESTERE ; Raul G. NOGUEIRA ; Alexander SALERNO ; Susanne WEGENER ; Philipp BAUMGARTNER ; Carlo W. CEREDA ; Giovanni BIANCO ; Morin BEYELER ; Marcel ARNOLD ; Emmanuel CARRERA ; Paolo MACHI ; Valerian ALTERSBERGER ; Leo BONATI ; Henrik GENSICKE ; Manuel BOLOGNESE ; Nils PETERS ; Stephan WETZEL ; Marta MAGRIÇO ; João NUNO RAMOS ; Rita MACHADO ; Carolina MAIA ; Egídio MACHADO ; Patrícia FERREIRA ; Teresa PINHO-E-MELO ; André PAULA ; Manuel Alberto CORREIA ; Pedro CASTRO ; Elsa AZEVEDO ; Luís ALBUQUERQUE ; José NUNO-ALVES ; Joana FERREIRA-PINTO ; Torcato MEIRA ; Liliana PEREIRA ; Miguel RODRIGUES ; André ARAÚJO ; Marta RODRIGUES ; Mariana ROCHA ; Ângelo PEREIRA-FONSECA ; Luís RIBEIRO ; Ricardo VARELA ; Sofia MALHEIRO ; Manuel CAPPELLARI ; Cecilia ZIVELONGHI ; Giulia SAJEVA ; Andrea ZINI ; Gentile MAURO ; Forlivesi STEFANO ; Ludovica MIGLIACCIO ; Maria SESSA ; Sara La GIOIA ; Alessandro PEZZINI ; Davide SANGALLI ; Marialuisa ZEDDE ; Rosario PASCARELLA ; Carlo FERRARESE ; Simone BERETTA ; Susanna DIAMANTI ; Ghil SCHWARZ ; Giovanni FRISULLO ; Pierre SENERS ; Candice SABBEN ; Michel PIOTIN ; Benjamin MAIER ; Guillaume CHARBONNIER ; Fabrice VUILLIER ; Loic LEGRIS ; Pauline CUISENIER ; Francesca R. VODRET ; Gaultier MARNAT ; Jean-Sebastien LIEGEY ; Igor SIBON ; Fabian FLOTTMANN ; Gabriel BROOCKS ; Nils-Ole GLOYER ; Ferdinand O. BOHMANN ; Jan Hendrik SCHAEFER ; Christian H. NOLTE ; Heinrich AUDEBERT ; Eberhard SIEBERT ; Marek SYKORA ; Wilfried LANG ; Julia FERRARI ; Lukas MAYER-SUESS ; Michael KNOFLACH ; Elke-Ruth GIZEWSKI ; Jeffrey STOLP ; Lotte J. STOLZE ; Paul J. NEDERKOORN ; Ido VAN-DEN-WIJNGAARD ; Joke DE MERIS ; Robin LEMMEN ; Sylvie DE RAEDT ; Fenne VANDERVORST ; Matthieu Pierre RUTGERS ; Antoine GUILMOT ; Anne DUSART ; Flavio BELLANTE ; Fernando OSTOS ; Guillermo GONZALEZ-ORTEGA ; Paloma MARTÍN-JIMÉNEZ ; Sebastian GARCÍA-MADRONA ; Antonio CRUZ-CULEBRAS ; Rocio VERA ; Maria-Consuelo MATUTE ; María ALONSO-DE-LECIÑANA ; Ricardo RIGUAL ; Exuperio DÍEZ-TEJEDOR ; Soledad PÉREZ-SÁNCHEZ ; Joan MONTANER ; Fernando DÍAZ-OTERO ; Natalia PEREZ-DE-LA-OSSA ; Belén FLORES-PINA ; Lucia MUÑOZ-NARBONA ; Angel CHAMORRO ; Alejandro RODRÍGUEZ-VÁZQUEZ ; Arturo RENÚ ; Francisco HERNANDEZ-FERNANDEZ ; Tomas SEGURA ; Herbert TEJADA-MEZA ; Daniel SAGARRA-MUR ; Marta SERRANO-PONZ ; Thant HLAING ; Isaiah SEE ; Robert SIMISTER ; David J. WERRING ; Espen Saxhaug KRISTOFFERSEN ; Annika NORDANSTIG ; Katarina JOOD ; Alexandros RENTZOS ; Libor ŠIMU˚NE ; Dagmar KRAJÍČKOVÁ ; Antonín KRAJINA ; Robert MIKULÍK ; Martina CVIKOVÁ ; Jan VINKLÁREK ; David ŠKOLOUDÍK ; Martin ROUBEC ; Eva HURTIKOVA ; Rostislav HRUBÝ ; Svatopluk OSTRY ; Ondrej SKODA ; Marek PERNICKA ; Lubomír KOČÍ ; Zuzana EICHLOVÁ ; Martin JÍRA ; Michal PANSKÝ ; Pavel MENCL ; Hana PALOUŠKOVÁ ; Aleš TOMEK ; Petr JANSKÝ ; Anna OLŠEROVÁ ; Roman HAVLÍČEK ; Petr MALÝ ; Lukáš TRAKAL ; Jan FIKSA ; Matěj SLOVÁK ; Michał KARLIŃSK ; Maciej NOWAK ; Halina SIENKIEWICZ-JAROSZ ; Anna BOCHYNSKA ; Tomasz HOMA ; Katarzyna SAWCZYNSKA ; Agnieszka SLOWIK ; Ewa WLODARCZYK ; Marcin WIĄCEK ; Izabella TOMASZEWSKA-LAMPART ; Bartosz SIECZKOWSKI ; Halina BARTOSIK-PSUJEK ; Marta BILIK ; Anna BANDZAREWICZ ; Justyna ZIELIŃSKA-TUREK ; Krystian OBARA ; Paweł URBANOWSKI ; Sławomir BUDREWICZ ; Maciej GUZIŃSKI ; Milena ŚWITOŃSKA ; Iwona RUTKOWSKA ; Paulina SOBIESZAK-SKURA ; Beata ŁABUZ-ROSZAK ; Aleksander DĘBIEC ; Jacek STASZEWSKI ; Adam STĘPIEŃ ; Jacek ZWIERNIK ; Grzegorz WASILEWSKI ; Cristina TIU ; Razvan-Alexandru RADU ; Anca NEGRILA ; Bogdan DOROBAT ; Cristina PANEA ; Vlad TIU ; Simona PETRESCU ; Atilla ÖZCAN-ÖZDEMIR ; Mostafa MAHMOUD ; Hussam EL-SAMAHY ; Hazem ABDELKHALEK ; Jasem AL-HASHEL ; Ismail IBRAHIM ISMAIL ; Athari SALMEEN ; Abdoreza GHOREISHI ; Sergiu SABETAY ; Hana GROSS ; Piers KLEIN ; Kareem EL NAAMANI ; Stavropoula TJOUMAKARIS ; Rawad ABBAS ; Ghada-A MOHAMED ; Alex CHEBL ; Jiangyong MIN ; Majesta HOVINGH ; Jenney-P TSAI ; Muhib-A KHAN ; Krishna NALLEBALLE ; Sanjeeva ONTEDDU ; Hesham-E MASOUD ; Mina MICHAEL ; Navreet KAUR ; Laith MAALI ; Michael ABRAHAM ; Ivo BACH ; Melody ONG ; Denis BABICI ; Ayaz-M. KHAWAJA ; Maryam HAKEMI ; Kumar RAJAMANI ; Vanessa CANO-NIGENDA ; Antonio ARAUZ ; Pablo AMAYA ; Natalia LLANOS ; Akemi ARANGO ; Miguel A. VENCES ; José-Domingo BARRIENTOS ; Rayllene CAETANO ; Rodrigo TARGA ; Sergio SCOLLO ; Patrick YALUNG ; Shashank NAGENDRA ; Abhijit GAIKWAD ; Kwon-Duk SEO ;
Journal of Stroke 2025;27(1):128-132
10.Carotid Web: An Update Focusing on Its Relationship With Fibromuscular Dysplasia and Therapeutic Strategy
Marialuisa ZEDDE ; Maria Simona STOENOIU ; Alexandre PERSU ; Rosario PASCARELLA
Journal of Stroke 2025;27(2):169-183
Carotid web was described more than 50 years ago as an atypical fibromuscular dysplasia (FMD) subtype with highly supporting pathological evidence as intimal FMD. In the following decades, the transition from catheter angiography or digital subtraction angiography (DSA) to non-invasive imaging techniques and the dramatic decrease in pathological procedures contributed to the gradual loss of this information. Currently, attention on the carotid web has increased due to its association with cryptogenic ischemic stroke. In fact, the underlying hypothesis is that the morphological features of the carotid web may determine a thrombogenic potential with artery-to-artery embolism. The pathology of the carotid web allowed identification of small thrombi embedded in the web pouch, and the features of thrombi endovascularly retrieved from intracranial arteries are very similar. The diagnosis of carotid web is usually made by non-invasive techniques, such as computed tomography angiography, ultrasound, and magnetic resonance imaging, requiring the concordance of two different techniques for confirming the diagnosis. DSA is usually considered in cases of diagnostic uncertainty and when interventional treatment of ischemic stroke or carotid web is considered. Treatment options in symptomatic cases include medical therapy (single or dual antiplatelets) or interventional approach (surgery or stenting), but there are no randomized controlled trials about therapy. The main aim of this review is to present the current knowledge on carotid web, retrieving historical data and angiographic classifications of FMD, as well as to discuss the biological plausibility of the association with stroke in symptomatic cases and the need for an updated classification of FMD, together with prospective data.


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